Do Polymorphisms in the Familial Parkinsonism Genes Contribute to Risk for Sporadic Parkinson's Disease?
Identifieur interne : 000F11 ( PascalFrancis/Checkpoint ); précédent : 000F10; suivant : 000F12Do Polymorphisms in the Familial Parkinsonism Genes Contribute to Risk for Sporadic Parkinson's Disease?
Auteurs : Greg T. Sutherland [Australie] ; Glenda M. Halliday [Australie] ; Peter A. Silburn [Australie] ; Frank L. Mastaglia [Australie] ; Dominic B. Rowe [Australie] ; Richard S. Boyle [Australie] ; John D. O'Sullivan [Australie] ; Tina Ly [Australie] ; Steve D. Wilton [Australie] ; George D. Mellick [Australie]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we use an alternative targeted candidate gene approach to examine common variation in 11 genes related to familial Parkinsonism. PD cases (n = 331) and unaffected control subjects (n = 296) were recruited from three specialist movement disorder clinics in Brisbane, Australia and the Australian Electoral Roll. Common genetic variables (76 SNPs and 1 STR) were assessed in all subjects and haplotype, genotype, and allele associations explored. Modest associations (uncorrected P < 0.05) were observed for common variants around SNCA, UCHL1, MAPT, and LRRK2 although none were of sufficient magnitude to survive strict statistical corrections for multiple comparisons. No associations were seen for PRKN, PINKI, GBA, ATP13A2, HTRA2, NR4A2, and DJI. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians.
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O'Sullivan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The School of Medicine, University of Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ly, Tina" sort="Ly, Tina" uniqKey="Ly T" first="Tina" last="Ly">Tina Ly</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Wilton, Steve D" sort="Wilton, Steve D" uniqKey="Wilton S" first="Steve D." last="Wilton">Steve D. Wilton</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0223192</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0223192 INIST</idno><idno type="RBID">Pascal:09-0223192</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F00</idno><idno type="wicri:Area/PascalFrancis/Curation">001E19</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Do Polymorphisms in the Familial Parkinsonism Genes Contribute to Risk for Sporadic Parkinson's Disease?</title><author><name sortKey="Sutherland, Greg T" sort="Sutherland, Greg T" uniqKey="Sutherland G" first="Greg T." last="Sutherland">Greg T. Sutherland</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Prince of Wales Medical Research Institute</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Prince of Wales Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The School of Medicine, University of Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank L." last="Mastaglia">Frank L. Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Rowe, Dominic B" sort="Rowe, Dominic B" uniqKey="Rowe D" first="Dominic B." last="Rowe">Dominic B. Rowe</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, Royal North Shore Hospital</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Boyle, Richard S" sort="Boyle, Richard S" uniqKey="Boyle R" first="Richard S." last="Boyle">Richard S. Boyle</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>The School of Medicine, University of Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ly, Tina" sort="Ly, Tina" uniqKey="Ly T" first="Tina" last="Ly">Tina Ly</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Wilton, Steve D" sort="Wilton, Steve D" uniqKey="Wilton S" first="Steve D." last="Wilton">Steve D. Wilton</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth, Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Parkinsonism</term><term>Polymorphism</term><term>Risk factor</term><term>Sporadic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Polymorphisme</term><term>Facteur risque</term><term>Sporadique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we use an alternative targeted candidate gene approach to examine common variation in 11 genes related to familial Parkinsonism. PD cases (n = 331) and unaffected control subjects (n = 296) were recruited from three specialist movement disorder clinics in Brisbane, Australia and the Australian Electoral Roll. Common genetic variables (76 SNPs and 1 STR) were assessed in all subjects and haplotype, genotype, and allele associations explored. Modest associations (uncorrected P < 0.05) were observed for common variants around SNCA, UCHL1, MAPT, and LRRK2 although none were of sufficient magnitude to survive strict statistical corrections for multiple comparisons. No associations were seen for PRKN, PINKI, GBA, ATP13A2, HTRA2, NR4A2, and DJI. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Do Polymorphisms in the Familial Parkinsonism Genes Contribute to Risk for Sporadic Parkinson's Disease?</s1></fA08><fA11 i1="01" i2="1"><s1>SUTHERLAND (Greg T.)</s1></fA11><fA11 i1="02" i2="1"><s1>HALLIDAY (Glenda M.)</s1></fA11><fA11 i1="03" i2="1"><s1>SILBURN (Peter A.)</s1></fA11><fA11 i1="04" i2="1"><s1>MASTAGLIA (Frank L.)</s1></fA11><fA11 i1="05" i2="1"><s1>ROWE (Dominic B.)</s1></fA11><fA11 i1="06" i2="1"><s1>BOYLE (Richard S.)</s1></fA11><fA11 i1="07" i2="1"><s1>O'SULLIVAN (John D.)</s1></fA11><fA11 i1="08" i2="1"><s1>LY (Tina)</s1></fA11><fA11 i1="09" i2="1"><s1>WILTON (Steve D.)</s1></fA11><fA11 i1="10" i2="1"><s1>MELLICK (George D.)</s1></fA11><fA14 i1="01"><s1>Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="02"><s1>Prince of Wales Medical Research Institute</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>The School of Medicine, University of Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="04"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth, Western Australia</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, Royal North Shore Hospital</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, Princess Alexandra Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, Royal Brisbane and Women's Hospital</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ></fA14><fA20><s1>833-838</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000186181820060</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>32 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0223192</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we use an alternative targeted candidate gene approach to examine common variation in 11 genes related to familial Parkinsonism. PD cases (n = 331) and unaffected control subjects (n = 296) were recruited from three specialist movement disorder clinics in Brisbane, Australia and the Australian Electoral Roll. Common genetic variables (76 SNPs and 1 STR) were assessed in all subjects and haplotype, genotype, and allele associations explored. Modest associations (uncorrected P < 0.05) were observed for common variants around SNCA, UCHL1, MAPT, and LRRK2 although none were of sufficient magnitude to survive strict statistical corrections for multiple comparisons. No associations were seen for PRKN, PINKI, GBA, ATP13A2, HTRA2, NR4A2, and DJI. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinsonisme</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinsonism</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson síndrome</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Polymorphisme</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Polymorphism</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Polimorfismo</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Facteur risque</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Risk factor</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Sporadique</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Sporadic</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Esporádico</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>38</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>38</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>39</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fN21><s1>166</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Sutherland, Greg T" sort="Sutherland, Greg T" uniqKey="Sutherland G" first="Greg T." last="Sutherland">Greg T. Sutherland</name></noRegion><name sortKey="Boyle, Richard S" sort="Boyle, Richard S" uniqKey="Boyle R" first="Richard S." last="Boyle">Richard S. Boyle</name><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><name sortKey="Ly, Tina" sort="Ly, Tina" uniqKey="Ly T" first="Tina" last="Ly">Tina Ly</name><name sortKey="Mastaglia, Frank L" sort="Mastaglia, Frank L" uniqKey="Mastaglia F" first="Frank L." last="Mastaglia">Frank L. Mastaglia</name><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><name sortKey="Rowe, Dominic B" sort="Rowe, Dominic B" uniqKey="Rowe D" first="Dominic B." last="Rowe">Dominic B. Rowe</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><name sortKey="Wilton, Steve D" sort="Wilton, Steve D" uniqKey="Wilton S" first="Steve D." last="Wilton">Steve D. Wilton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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