MovDisordV3, PascalFrancis, Checkpoint, bibRecord, 000F13

Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes

Identifieur interne : 000F13 ( PascalFrancis/Checkpoint ); précédent : 000F12; suivant : 000F14

Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes

Auteurs : Maria Teresa Pellecchia [Italie] ; Paolo Barone [Italie] ; Carmine Mollica [Italie] ; Elena Salvatore [Italie] ; Marta Ianniciello [Italie] ; Katia Longo [Italie] ; Andrea Varrone [Italie] ; Caterina Vicidomini [Italie] ; Marina Picillo [Italie] ; Giuseppe De Michele [Italie] ; Alessandro Filla [Italie] ; Marco Salvatore [Italie] ; Sabina Pappata [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0218134

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Pathologie du système nerveux, Etude comparative, Soustype, Imagerie RMN, Imagerie de diffusion.

English descriptors

KwdEn :
- Comparative study, Diffusion imaging, Multiple system atrophy, Nervous system diseases, Nuclear magnetic resonance imaging, Subtype.

Abstract

Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA-P) and a cerebellar (MSA-C) variant based on clinical presentation. We obtained diffusion-weighted magnetic resonance imaging (DWI) in 9 MSA-P and 12 MSA-C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA-P than in MSA-C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA-C than in MSA-P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA-P patients, and in cerebellum and MCP of MSA-C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA-P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA-P and MSA-C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurode-generation in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease.

Affiliations:

Italie

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000F27
to stream PascalFrancis, to step Curation: 001D92

Links to Exploration step

Pascal:09-0218134

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes</title>
<author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>IRCCS Fondazione SDN</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>IRCCS Fondazione SDN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappata">Sabina Pappata</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0218134</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0218134 INIST</idno>
<idno type="RBID">Pascal:09-0218134</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000F27</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001D92</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000F13</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes</title>
<author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>IRCCS Fondazione SDN</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>IRCCS Fondazione SDN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappata">Sabina Pappata</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term>
<term>Diffusion imaging</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Subtype</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Pathologie du   système nerveux</term>
<term>Etude comparative</term>
<term>Soustype</term>
<term>Imagerie RMN</term>
<term>Imagerie de diffusion</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA-P) and a cerebellar (MSA-C) variant based on clinical presentation. We obtained diffusion-weighted magnetic resonance imaging (DWI) in 9 MSA-P and 12 MSA-C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA-P than in MSA-C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA-C than in MSA-P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA-P patients, and in cerebellum and MCP of MSA-C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA-P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA-P and MSA-C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurode-generation in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>24</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>PELLECCHIA (Maria Teresa)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BARONE (Paolo)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>MOLLICA (Carmine)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>SALVATORE (Elena)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>IANNICIELLO (Marta)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>LONGO (Katia)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>VARRONE (Andrea)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>VICIDOMINI (Caterina)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>PICILLO (Marina)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>DE MICHELE (Giuseppe)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>FILLA (Alessandro)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>SALVATORE (Marco)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>PAPPATA (Sabina)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>IRCCS Fondazione SDN</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA20><s1>689-696</s1>
</fA20>
<fA21><s1>2009</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000186090170090</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>21 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0218134</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA-P) and a cerebellar (MSA-C) variant based on clinical presentation. We obtained diffusion-weighted magnetic resonance imaging (DWI) in 9 MSA-P and 12 MSA-C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA-P than in MSA-C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA-C than in MSA-P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA-P patients, and in cerebellum and MCP of MSA-C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA-P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA-P and MSA-C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurode-generation in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17F</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Multiple system atrophy</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Soustype</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Subtype</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Subtipo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Imagerie RMN</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Imaginería RMN</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Imagerie de diffusion</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Diffusion imaging</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fN21><s1>159</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name>
</noRegion>
<name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
<name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name>
<name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name>
<name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name>
<name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name>
<name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappata">Sabina Pappata</name>
<name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name>
<name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name>
<name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name>
<name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F13 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000F13 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    PascalFrancis
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Pascal:09-0218134
   |texte=   Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes

Diffusion-Weighted Imaging in Multiple System Atrophy : A Comparison Between Clinical Subtypes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri