Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes
Identifieur interne : 000156 ( PascalFrancis/Checkpoint ); précédent : 000155; suivant : 000157Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes
Auteurs : Alexander Storch [Allemagne] ; Ilona Csoti [Allemagne] ; Karla Eggert [Allemagne] ; Tove Henriksen [Danemark] ; Annika Plate [Allemagne] ; Michael Lorrain [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Angelo Antonini [Italie]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cellule souche.
English descriptors
- KwdEn :
Abstract
Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.
Affiliations:
- Allemagne, Danemark, Italie
- Bavière, District de Dresde, District de Giessen, District de Haute-Bavière, Hesse (Land), Hovedstaden, Saxe (Land)
- Copenhague, Dresde, Marbourg, Munich
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Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo</s1><s2>Venice</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Venice</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0423956</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0423956 INIST</idno><idno type="RBID">Pascal:12-0423956</idno><idno type="wicri:Area/PascalFrancis/Corpus">000051</idno><idno type="wicri:Area/PascalFrancis/Curation">002C63</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000156</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes</title><author><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology</s1><s2>Dresden</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>German Center for Neurodegenerative Diseases (DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen), Research Site Dresden</s1><s2>Dresden</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Center for Regenerative Therapies Dresden (CRTD)</s1><s2>Dresden</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Csoti, Ilona" sort="Csoti, Ilona" uniqKey="Csoti I" first="Ilona" last="Csoti">Ilona Csoti</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Gertrudis Klinik, Parkinson-Center</s1><s2>Leun-Biskirchen</s2><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Leun-Biskirchen</wicri:noRegion><wicri:noRegion>Parkinson-Center</wicri:noRegion><wicri:noRegion>Leun-Biskirchen</wicri:noRegion></affiliation></author><author><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurology, University Hospital of Bispebjerg</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>4 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Plate, Annika" sort="Plate, Annika" uniqKey="Plate A" first="Annika" last="Plate">Annika Plate</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, Ludwig Maximillians University</s1><s2>Munich</s2><s3>DEU</s3><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Neurological Practice Düsseldorf</s1><s2>Dusseldorf</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Dusseldorf</wicri:noRegion><wicri:noRegion>Neurological Practice Düsseldorf</wicri:noRegion><wicri:noRegion>Neurological Practice Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo</s1><s2>Venice</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Venice</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autologous system</term><term>Bone marrow</term><term>Intrathecal</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Preparation</term><term>Stem cell</term><term>Stroma</term><term>Transplantation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Atrophie multisystématisée</term><term>Pathologie du système nerveux</term><term>Intrarachidien</term><term>Système autologue</term><term>Moelle osseuse</term><term>Préparation</term><term>Cellule souche</term><term>Stroma</term><term>Transplantation</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>12</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes</s1></fA08><fA11 i1="01" i2="1"><s1>STORCH (Alexander)</s1></fA11><fA11 i1="02" i2="1"><s1>CSOTI (Ilona)</s1></fA11><fA11 i1="03" i2="1"><s1>EGGERT (Karla)</s1></fA11><fA11 i1="04" i2="1"><s1>HENRIKSEN (Tove)</s1></fA11><fA11 i1="05" i2="1"><s1>PLATE (Annika)</s1></fA11><fA11 i1="06" i2="1"><s1>LORRAIN (Michael)</s1></fA11><fA11 i1="07" i2="1"><s1>OERTEL (Wolfgang H.)</s1></fA11><fA11 i1="08" i2="1"><s1>ANTONINI (Angelo)</s1></fA11><fA14 i1="01"><s1>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology</s1><s2>Dresden</s2><s3>DEU</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>German Center for Neurodegenerative Diseases (DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen), Research Site Dresden</s1><s2>Dresden</s2><s3>DEU</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Center for Regenerative Therapies Dresden (CRTD)</s1><s2>Dresden</s2><s3>DEU</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Gertrudis Klinik, Parkinson-Center</s1><s2>Leun-Biskirchen</s2><s3>DEU</s3><sZ>2 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurology, University Hospital of Bispebjerg</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>4 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, Ludwig Maximillians University</s1><s2>Munich</s2><s3>DEU</s3><sZ>5 aut.</sZ></fA14><fA14 i1="08"><s1>Neurological Practice Düsseldorf</s1><s2>Dusseldorf</s2><s3>DEU</s3><sZ>6 aut.</sZ></fA14><fA14 i1="09"><s1>Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo</s1><s2>Venice</s2><s3>ITA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1552-1555</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000502081650140</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>26 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0423956</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002A25L</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Multiple system atrophy</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Intrarachidien</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Intrathecal</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Intratecal</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Système autologue</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Autologous system</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Sistema autólogo</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Moelle osseuse</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Bone marrow</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Médula ósea</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Préparation</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Preparation</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Preparación</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Cellule souche</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Stem cell</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Célula primitiva</s0><s5>13</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Stroma</s0><s5>14</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Stroma</s0><s5>14</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Estroma</s0><s5>14</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Transplantation</s0><s5>15</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Transplantation</s0><s5>15</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Trasplantación</s0><s5>15</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>331</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>Italie</li></country><region><li>Bavière</li><li>District de Dresde</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>Hesse (Land)</li><li>Hovedstaden</li><li>Saxe (Land)</li></region><settlement><li>Copenhague</li><li>Dresde</li><li>Marbourg</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name></region><name sortKey="Csoti, Ilona" sort="Csoti, Ilona" uniqKey="Csoti I" first="Ilona" last="Csoti">Ilona Csoti</name><name sortKey="Eggert, Karla" sort="Eggert, Karla" uniqKey="Eggert K" first="Karla" last="Eggert">Karla Eggert</name><name sortKey="Lorrain, Michael" sort="Lorrain, Michael" uniqKey="Lorrain M" first="Michael" last="Lorrain">Michael Lorrain</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Plate, Annika" sort="Plate, Annika" uniqKey="Plate A" first="Annika" last="Plate">Annika Plate</name><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name><name sortKey="Storch, Alexander" sort="Storch, Alexander" uniqKey="Storch A" first="Alexander" last="Storch">Alexander Storch</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Henriksen, Tove" sort="Henriksen, Tove" uniqKey="Henriksen T" first="Tove" last="Henriksen">Tove Henriksen</name></region></country><country name="Italie"><noRegion><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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