Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm
Identifieur interne : 000155 ( PascalFrancis/Checkpoint ); précédent : 000154; suivant : 000156Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm
Auteurs : James M. Shine [Australie] ; Glenda H. Halliday [Australie] ; Mayra Carlos [Australie] ; Sharon L. Naismith [Australie] ; Simon J. G. Lewis [Australie]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:12-0183707Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm</title><author><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M." last="Shine">James M. Shine</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Halliday, Glenda H" sort="Halliday, Glenda H" uniqKey="Halliday G" first="Glenda H." last="Halliday">Glenda H. Halliday</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Research Australia and the University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Neuroscience Research Australia and the University of New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Carlos, Mayra" sort="Carlos, Mayra" uniqKey="Carlos M" first="Mayra" last="Carlos">Mayra Carlos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L." last="Naismith">Sharon L. Naismith</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J. G." last="Lewis">Simon J. G. Lewis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0183707</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0183707 INIST</idno><idno type="RBID">Pascal:12-0183707</idno><idno type="wicri:Area/PascalFrancis/Corpus">000236</idno><idno type="wicri:Area/PascalFrancis/Curation">002A78</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000155</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm</title><author><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M." last="Shine">James M. Shine</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Halliday, Glenda H" sort="Halliday, Glenda H" uniqKey="Halliday G" first="Glenda H." last="Halliday">Glenda H. Halliday</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroscience Research Australia and the University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>2 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Neuroscience Research Australia and the University of New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Carlos, Mayra" sort="Carlos, Mayra" uniqKey="Carlos M" first="Mayra" last="Carlos">Mayra Carlos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L." last="Naismith">Sharon L. Naismith</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J. G." last="Lewis">Simon J. G. Lewis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term><term>Parkinson disease</term><term>Visual hallucination</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Hallucination visuelle</term><term>Pathologie du système nerveux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm</s1></fA08><fA11 i1="01" i2="1"><s1>SHINE (James M.)</s1></fA11><fA11 i1="02" i2="1"><s1>HALLIDAY (Glenda H.)</s1></fA11><fA11 i1="03" i2="1"><s1>CARLOS (Mayra)</s1></fA11><fA11 i1="04" i2="1"><s1>NAISMITH (Sharon L.)</s1></fA11><fA11 i1="05" i2="1"><s1>LEWIS (Simon J. G.)</s1></fA11><fA14 i1="01"><s1>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="02"><s1>Neuroscience Research Australia and the University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>2 aut.</sZ></fA14><fA20><s1>500-505</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000194678450100</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>39 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0183707</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Hallucination visuelle</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Visual hallucination</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Alucinación visual</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>142</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M." last="Shine">James M. Shine</name></noRegion><name sortKey="Carlos, Mayra" sort="Carlos, Mayra" uniqKey="Carlos M" first="Mayra" last="Carlos">Mayra Carlos</name><name sortKey="Halliday, Glenda H" sort="Halliday, Glenda H" uniqKey="Halliday G" first="Glenda H." last="Halliday">Glenda H. Halliday</name><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J. G." last="Lewis">Simon J. G. Lewis</name><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L." last="Naismith">Sharon L. Naismith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000155 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000155 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:12-0183707
|texte= Investigating Visual Misperceptions in Parkinson's Disease: A Novel Behavioral Paradigm
}}
| This area was generated with Dilib version V0.6.23. |  |