MovDisordV3, PascalFrancis, Corpus, bibRecord, 000051

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Identifieur interne : 000051 ( PascalFrancis/Corpus ); précédent : 000050; suivant : 000052

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Auteurs : Alexander Storch ; Ilona Csoti ; Karla Eggert ; Tove Henriksen ; Annika Plate ; Michael Lorrain ; Wolfgang H. Oertel ; Angelo Antonini

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0423956

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Atrophie multisystématisée, Pathologie du système nerveux, Intrarachidien, Système autologue, Moelle osseuse, Préparation, Cellule souche, Stroma, Transplantation.

English descriptors

KwdEn :
- Autologous system, Bone marrow, Intrathecal, Multiple system atrophy, Nervous system diseases, Parkinson disease, Preparation, Stem cell, Stroma, Transplantation.

Abstract

Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 STORCH (Alexander)`
A11	`02`	`1`		`@1 CSOTI (Ilona)`
A11	`03`	`1`		`@1 EGGERT (Karla)`
A11	`04`	`1`		`@1 HENRIKSEN (Tove)`
A11	`05`	`1`		`@1 PLATE (Annika)`
A11	`06`	`1`		`@1 LORRAIN (Michael)`
A11	`07`	`1`		`@1 OERTEL (Wolfgang H.)`
A11	`08`	`1`		`@1 ANTONINI (Angelo)`
A14	`01`			`@1 Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology @2 Dresden @3 DEU @Z 1 aut.`
A14	`02`			`@1 German Center for Neurodegenerative Diseases (DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen), Research Site Dresden @2 Dresden @3 DEU @Z 1 aut.`
A14	`03`			`@1 Center for Regenerative Therapies Dresden (CRTD) @2 Dresden @3 DEU @Z 1 aut.`
A14	`04`			`@1 Gertrudis Klinik, Parkinson-Center @2 Leun-Biskirchen @3 DEU @Z 2 aut.`
A14	`05`			`@1 Department of Neurology, Philipps University Marburg @2 Marburg @3 DEU @Z 3 aut. @Z 7 aut.`
A14	`06`			`@1 Department of Neurology, University Hospital of Bispebjerg @2 Copenhagen @3 DNK @Z 4 aut.`
A14	`07`			`@1 Department of Neurology, Ludwig Maximillians University @2 Munich @3 DEU @Z 5 aut.`
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C01	`01`		`ENG`	@0 Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.
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C03	`02`	`X`	`ENG`	`@0 Multiple system atrophy @2 NM @5 02`
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C03	`04`	`X`	`SPA`	`@0 Intratecal @5 09`
C03	`05`	`X`	`FRE`	`@0 Système autologue @5 10`
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C03	`05`	`X`	`SPA`	`@0 Sistema autólogo @5 10`
C03	`06`	`X`	`FRE`	`@0 Moelle osseuse @5 11`
C03	`06`	`X`	`ENG`	`@0 Bone marrow @5 11`
C03	`06`	`X`	`SPA`	`@0 Médula ósea @5 11`
C03	`07`	`X`	`FRE`	`@0 Préparation @5 12`
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C03	`07`	`X`	`SPA`	`@0 Preparación @5 12`
C03	`08`	`X`	`FRE`	`@0 Cellule souche @5 13`
C03	`08`	`X`	`ENG`	`@0 Stem cell @5 13`
C03	`08`	`X`	`SPA`	`@0 Célula primitiva @5 13`
C03	`09`	`X`	`FRE`	`@0 Stroma @5 14`
C03	`09`	`X`	`ENG`	`@0 Stroma @5 14`
C03	`09`	`X`	`SPA`	`@0 Estroma @5 14`
C03	`10`	`X`	`FRE`	`@0 Transplantation @5 15`
C03	`10`	`X`	`ENG`	`@0 Transplantation @5 15`
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C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
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C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
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N21				`@1 331`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 12-0423956 INIST
ET :	Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes
AU :	STORCH (Alexander); CSOTI (Ilona); EGGERT (Karla); HENRIKSEN (Tove); PLATE (Annika); LORRAIN (Michael); OERTEL (Wolfgang H.); ANTONINI (Angelo)
AF :	Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology/Dresden/Allemagne (1 aut.); German Center for Neurodegenerative Diseases (DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen), Research Site Dresden/Dresden/Allemagne (1 aut.); Center for Regenerative Therapies Dresden (CRTD)/Dresden/Allemagne (1 aut.); Gertrudis Klinik, Parkinson-Center/Leun-Biskirchen/Allemagne (2 aut.); Department of Neurology, Philipps University Marburg/Marburg/Allemagne (3 aut., 7 aut.); Department of Neurology, University Hospital of Bispebjerg/Copenhagen/Danemark (4 aut.); Department of Neurology, Ludwig Maximillians University/Munich/Allemagne (5 aut.); Neurological Practice Düsseldorf/Dusseldorf/Allemagne (6 aut.); Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo/Venice/Italie (8 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 12; Pp. 1552-1555; Bibl. 26 ref.
LA :	Anglais
EA :	Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.
CC :	002B17; 002A25L
FD :	Maladie de Parkinson; Atrophie multisystématisée; Pathologie du système nerveux; Intrarachidien; Système autologue; Moelle osseuse; Préparation; Cellule souche; Stroma; Transplantation
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Multiple system atrophy; Nervous system diseases; Intrathecal; Autologous system; Bone marrow; Preparation; Stem cell; Stroma; Transplantation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Atrofia multisistematizada; Sistema nervioso patología; Intratecal; Sistema autólogo; Médula ósea; Preparación; Célula primitiva; Estroma; Trasplantación
LO :	INIST-20953.354000502081650140
ID :	12-0423956

Links to Exploration step

Pascal:12-0423956

Le document en format XML

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<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autologous system</term>
<term>Bone marrow</term>
<term>Intrathecal</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Preparation</term>
<term>Stem cell</term>
<term>Stroma</term>
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</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Atrophie multisystématisée</term>
<term>Pathologie du   système nerveux</term>
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<term>Système autologue</term>
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<front><div type="abstract" xml:lang="en">Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</div>
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<fA11 i1="07" i2="1"><s1>OERTEL (Wolfgang H.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>ANTONINI (Angelo)</s1>
</fA11>
<fA14 i1="01"><s1>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology</s1>
<s2>Dresden</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>German Center for Neurodegenerative Diseases (DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen), Research Site Dresden</s1>
<s2>Dresden</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Center for Regenerative Therapies Dresden (CRTD)</s1>
<s2>Dresden</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Gertrudis Klinik, Parkinson-Center</s1>
<s2>Leun-Biskirchen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, Philipps University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Department of Neurology, University Hospital of Bispebjerg</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurology, Ludwig Maximillians University</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Neurological Practice Düsseldorf</s1>
<s2>Dusseldorf</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo</s1>
<s2>Venice</s2>
<s3>ITA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>1552-1555</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000502081650140</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>26 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0423956</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CC</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A25L</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Multiple system atrophy</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0>
<s2>NM</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Intrarachidien</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Intrathecal</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Intratecal</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Système autologue</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Autologous system</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Sistema autólogo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Moelle osseuse</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Bone marrow</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Médula ósea</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Préparation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Preparation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Preparación</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Cellule souche</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Stem cell</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Célula primitiva</s0>
<s5>13</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Stroma</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Stroma</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Estroma</s0>
<s5>14</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Transplantation</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Transplantation</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Trasplantación</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>331</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0423956 INIST</NO>
<ET>Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes</ET>
<AU>STORCH (Alexander); CSOTI (Ilona); EGGERT (Karla); HENRIKSEN (Tove); PLATE (Annika); LORRAIN (Michael); OERTEL (Wolfgang H.); ANTONINI (Angelo)</AU>
<AF>Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology/Dresden/Allemagne (1 aut.); German Center for Neurodegenerative Diseases (DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen), Research Site Dresden/Dresden/Allemagne (1 aut.); Center for Regenerative Therapies Dresden (CRTD)/Dresden/Allemagne (1 aut.); Gertrudis Klinik, Parkinson-Center/Leun-Biskirchen/Allemagne (2 aut.); Department of Neurology, Philipps University Marburg/Marburg/Allemagne (3 aut., 7 aut.); Department of Neurology, University Hospital of Bispebjerg/Copenhagen/Danemark (4 aut.); Department of Neurology, Ludwig Maximillians University/Munich/Allemagne (5 aut.); Neurological Practice Düsseldorf/Dusseldorf/Allemagne (6 aut.); Department for Parkinson disease, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Camillo/Venice/Italie (8 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2012; Vol. 27; No. 12; Pp. 1552-1555; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.</EA>
<CC>002B17; 002A25L</CC>
<FD>Maladie de Parkinson; Atrophie multisystématisée; Pathologie du   système nerveux; Intrarachidien; Système autologue; Moelle osseuse; Préparation; Cellule souche; Stroma; Transplantation</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Multiple system atrophy; Nervous system diseases; Intrathecal; Autologous system; Bone marrow; Preparation; Stem cell; Stroma; Transplantation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Atrofia multisistematizada; Sistema nervioso patología; Intratecal; Sistema autólogo; Médula ósea; Preparación; Célula primitiva; Estroma; Trasplantación</SD>
<LO>INIST-20953.354000502081650140</LO>
<ID>12-0423956</ID>
</server>
</inist>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

Intrathecal Application of Autologous Bone Marrow Cell Preparations in Parkinsonian Syndromes

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