Calcium channel blocker use and risk of Parkinson’s disease
Identifieur interne : 002D16 ( Ncbi/Merge ); précédent : 002D15; suivant : 002D17Calcium channel blocker use and risk of Parkinson’s disease
Auteurs : K Claire Simon [États-Unis] ; Xiang Gao [États-Unis] ; Honglei Chen [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Alberto Ascherio [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Calcium Channel Blockers.
- drug therapy : Hypertension.
- etiology : Parkinson Disease.
- Female, Humans, Male, Nurses, Proportional Hazards Models, Risk.
Abstract
To investigate whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson’s disease (PD) in two large prospective cohorts.
Prospective cohort study among participants in two ongoing studies – the Nurses’ Health Study (NHS) and Health Professionals’ Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders.
We identified 514 incident cases of PD during follow-up of individuals enrolled in the NHS and HPFS. No association between baseline use of CCBs (RR=1.18, 95% CI: 0.73, 1.92), frequency of use or duration of use of CCBs and PD risk was observed (P>0.2 for all).
These findings do no support a role for CCBs in providing neuroprotection against development of PD.
Url:
DOI: 10.1002/mds.23191
PubMed: 20669249
PubMed Central: 2939261
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Schwarzschild</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium Channel Blockers (therapeutic use)</term><term>Female</term><term>Humans</term><term>Hypertension (drug therapy)</term><term>Male</term><term>Nurses</term><term>Parkinson Disease (etiology)</term><term>Proportional Hazards Models</term><term>Risk</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Calcium Channel Blockers</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Nurses</term><term>Proportional Hazards Models</term><term>Risk</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To investigate whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson’s disease (PD) in two large prospective cohorts.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Prospective cohort study among participants in two ongoing studies – the Nurses’ Health Study (NHS) and Health Professionals’ Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders.</p><p id="P3">We identified 514 incident cases of PD during follow-up of individuals enrolled in the NHS and HPFS. No association between baseline use of CCBs (RR=1.18, 95% CI: 0.73, 1.92), frequency of use or duration of use of CCBs and PD risk was observed (P>0.2 for all).</p></sec><sec id="S3"><title>Conclusions</title><p id="P4">These findings do no support a role for CCBs in providing neuroprotection against development of PD.</p></sec></div></front></TEI><double pmid="20669249"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calcium channel blocker use and risk of Parkinson’s disease</title><author><name sortKey="Simon, K Claire" sort="Simon, K Claire" uniqKey="Simon K" first="K Claire" last="Simon">K Claire Simon</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><affiliation wicri:level="2"><nlm:aff id="A3">Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20669249</idno><idno type="pmc">2939261</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939261</idno><idno type="RBID">PMC:2939261</idno><idno type="doi">10.1002/mds.23191</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000104</idno><idno type="wicri:Area/Pmc/Curation">000104</idno><idno type="wicri:Area/Pmc/Checkpoint">000362</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Calcium channel blocker use and risk of Parkinson’s disease</title><author><name sortKey="Simon, K Claire" sort="Simon, K Claire" uniqKey="Simon K" first="K Claire" last="Simon">K Claire Simon</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><affiliation wicri:level="2"><nlm:aff id="A3">Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea></affiliation></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Harvard School of Public Health, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Epidemiology, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To investigate whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson’s disease (PD) in two large prospective cohorts.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Prospective cohort study among participants in two ongoing studies – the Nurses’ Health Study (NHS) and Health Professionals’ Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders.</p><p id="P3">We identified 514 incident cases of PD during follow-up of individuals enrolled in the NHS and HPFS. No association between baseline use of CCBs (RR=1.18, 95% CI: 0.73, 1.92), frequency of use or duration of use of CCBs and PD risk was observed (P>0.2 for all).</p></sec><sec id="S3"><title>Conclusions</title><p id="P4">These findings do no support a role for CCBs in providing neuroprotection against development of PD.</p></sec></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calcium channel blocker use and risk of Parkinson's disease.</title><author><name sortKey="Simon, Kelly Claire" sort="Simon, Kelly Claire" uniqKey="Simon K" first="Kelly Claire" last="Simon">Kelly Claire Simon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. ksimon@hsph.harvard.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23191</idno><idno type="RBID">pubmed:20669249</idno><idno type="pmid">20669249</idno><idno type="wicri:Area/PubMed/Corpus">001701</idno><idno type="wicri:Area/PubMed/Curation">001701</idno><idno type="wicri:Area/PubMed/Checkpoint">001A14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Calcium channel blocker use and risk of Parkinson's disease.</title><author><name sortKey="Simon, Kelly Claire" sort="Simon, Kelly Claire" uniqKey="Simon K" first="Kelly Claire" last="Simon">Kelly Claire Simon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. ksimon@hsph.harvard.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name></author><author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name></author><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Calcium Channel Blockers (therapeutic use)</term><term>Female</term><term>Humans</term><term>Hypertension (drug therapy)</term><term>Male</term><term>Nurses</term><term>Parkinson Disease (etiology)</term><term>Proportional Hazards Models</term><term>Risk</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Calcium Channel Blockers</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypertension</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Nurses</term><term>Proportional Hazards Models</term><term>Risk</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson's disease (PD) in two large prospective cohorts: the Nurses' Health Study (NHS) and Health Professionals' Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders. We identified 514 incident cases of PD during follow-up. No association between baseline use of CCBs (RR = 1.18, 95% CI: 0.73-1.92), frequency of use or duration of use of CCBs and PD risk was observed (P > 0.2 for all). These findings do not support a role for CCBs in providing neuroprotection against development of PD.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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