Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome.
Identifieur interne : 002D17 ( Ncbi/Merge ); précédent : 002D16; suivant : 002D18Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome.
Auteurs : Stephanie Franzkowiak [Allemagne] ; Bettina Pollok ; Katja Biermann-Ruben ; Martin Südmeyer ; Jennifer Paszek ; Melanie Jonas ; Götz Thomalla ; Tobias B Umer ; Michael Orth ; Alexander Münchau ; Alfons SchnitzlerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- physiology : Cortical Synchronization, Evoked Potentials, Motor, Movement, Neural Inhibition.
- physiopathology : Motor Cortex, Tourette Syndrome.
- Adult, Female, Fingers, Humans, Magnetoencephalography, Male, Middle Aged.
Abstract
In patients with Gilles de la Tourette syndrome (GTS) alterations of motor cortex (M1) excitability at rest have been evidenced. In contrast, there has so far been little research into changes of motor cortical reactivity during the time course of voluntary movements in GTS patients. The present study investigates neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) of bilateral M1 in 11 GTS patients and 11 healthy control subjects. ERD represents motor cortical activation, whereas ERS most likely indicates its inhibition. Subjects performed a self-paced finger movement task while magnetoencephalography was used to record neuromagnetic activity. In GTS patients, ERD at beta frequency was significantly increased in the contralateral hemisphere before and during movements, whereas ERS following movement termination was increased in M1 ipsilateral. Ipsilateral ERS was inversely correlated with tic severity as determined by the Yale Global Tic Severity Rating Scale. The data of the present study support the hypothesis that during voluntary movements, motor cortical reactivity is pathologically altered in GTS patients. The observed pattern of increased activation (ERD) prior to and during movement execution followed by increased inhibition (ERS) after movement termination at beta frequency suggests abnormally increased motor cortical activation, possibly driving stronger inhibition. The stronger this inhibition is, the better symptoms appear to be controlled.
DOI: 10.1002/mds.23186
PubMed: 20669250
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Pollok</name></author><author><name sortKey="Biermann Ruben, Katja" sort="Biermann Ruben, Katja" uniqKey="Biermann Ruben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name></author><author><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name></author><author><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name></author><author><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23186</idno><idno type="RBID">pubmed:20669250</idno><idno type="pmid">20669250</idno><idno type="wicri:Area/PubMed/Corpus">001700</idno><idno type="wicri:Area/PubMed/Curation">001700</idno><idno type="wicri:Area/PubMed/Checkpoint">001A47</idno><idno type="wicri:Area/Ncbi/Merge">002D17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome.</title><author><name sortKey="Franzkowiak, Stephanie" sort="Franzkowiak, Stephanie" uniqKey="Franzkowiak S" first="Stephanie" last="Franzkowiak">Stephanie Franzkowiak</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Duesseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Duesseldorf</wicri:regionArea><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion><wicri:noRegion>Duesseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name></author><author><name sortKey="Biermann Ruben, Katja" sort="Biermann Ruben, Katja" uniqKey="Biermann Ruben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name></author><author><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name></author><author><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name></author><author><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name></author><author><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></author><author><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name></author><author><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name></author><author><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cortical Synchronization (physiology)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Fingers</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Movement (physiology)</term><term>Neural Inhibition (physiology)</term><term>Tourette Syndrome (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cortical Synchronization</term><term>Evoked Potentials, Motor</term><term>Movement</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Fingers</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In patients with Gilles de la Tourette syndrome (GTS) alterations of motor cortex (M1) excitability at rest have been evidenced. In contrast, there has so far been little research into changes of motor cortical reactivity during the time course of voluntary movements in GTS patients. The present study investigates neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) of bilateral M1 in 11 GTS patients and 11 healthy control subjects. ERD represents motor cortical activation, whereas ERS most likely indicates its inhibition. Subjects performed a self-paced finger movement task while magnetoencephalography was used to record neuromagnetic activity. In GTS patients, ERD at beta frequency was significantly increased in the contralateral hemisphere before and during movements, whereas ERS following movement termination was increased in M1 ipsilateral. Ipsilateral ERS was inversely correlated with tic severity as determined by the Yale Global Tic Severity Rating Scale. The data of the present study support the hypothesis that during voluntary movements, motor cortical reactivity is pathologically altered in GTS patients. The observed pattern of increased activation (ERD) prior to and during movement execution followed by increased inhibition (ERS) after movement termination at beta frequency suggests abnormally increased motor cortical activation, possibly driving stronger inhibition. The stronger this inhibition is, the better symptoms appear to be controlled.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20669250</PMID><DateCreated><Year>2010</Year><Month>09</Month><Day>14</Day></DateCreated><DateCompleted><Year>2010</Year><Month>12</Month><Day>28</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>12</Issue><PubDate><Year>2010</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Altered pattern of motor cortical activation-inhibition during voluntary movements in Tourette syndrome.</ArticleTitle><Pagination><MedlinePgn>1960-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23186</ELocationID><Abstract><AbstractText>In patients with Gilles de la Tourette syndrome (GTS) alterations of motor cortex (M1) excitability at rest have been evidenced. In contrast, there has so far been little research into changes of motor cortical reactivity during the time course of voluntary movements in GTS patients. The present study investigates neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) of bilateral M1 in 11 GTS patients and 11 healthy control subjects. ERD represents motor cortical activation, whereas ERS most likely indicates its inhibition. Subjects performed a self-paced finger movement task while magnetoencephalography was used to record neuromagnetic activity. In GTS patients, ERD at beta frequency was significantly increased in the contralateral hemisphere before and during movements, whereas ERS following movement termination was increased in M1 ipsilateral. Ipsilateral ERS was inversely correlated with tic severity as determined by the Yale Global Tic Severity Rating Scale. The data of the present study support the hypothesis that during voluntary movements, motor cortical reactivity is pathologically altered in GTS patients. The observed pattern of increased activation (ERD) prior to and during movement execution followed by increased inhibition (ERS) after movement termination at beta frequency suggests abnormally increased motor cortical activation, possibly driving stronger inhibition. The stronger this inhibition is, the better symptoms appear to be controlled.</AbstractText><CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Franzkowiak</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Duesseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pollok</LastName><ForeName>Bettina</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Biermann-Ruben</LastName><ForeName>Katja</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Südmeyer</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Paszek</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Jonas</LastName><ForeName>Melanie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Thomalla</LastName><ForeName>Götz</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Bäumer</LastName><ForeName>Tobias</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Orth</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Münchau</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Schnitzler</LastName><ForeName>Alfons</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003344">Cortical Synchronization</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019054">Evoked Potentials, Motor</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005385">Fingers</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015225">Magnetoencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009068">Movement</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005879">Tourette Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23186</ArticleId><ArticleId IdType="pubmed">20669250</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name><name sortKey="Biermann Ruben, Katja" sort="Biermann Ruben, Katja" uniqKey="Biermann Ruben K" first="Katja" last="Biermann-Ruben">Katja Biermann-Ruben</name><name sortKey="Jonas, Melanie" sort="Jonas, Melanie" uniqKey="Jonas M" first="Melanie" last="Jonas">Melanie Jonas</name><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><name sortKey="Orth, Michael" sort="Orth, Michael" uniqKey="Orth M" first="Michael" last="Orth">Michael Orth</name><name sortKey="Paszek, Jennifer" sort="Paszek, Jennifer" uniqKey="Paszek J" first="Jennifer" last="Paszek">Jennifer Paszek</name><name sortKey="Pollok, Bettina" sort="Pollok, Bettina" uniqKey="Pollok B" first="Bettina" last="Pollok">Bettina Pollok</name><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><name sortKey="Sudmeyer, Martin" sort="Sudmeyer, Martin" uniqKey="Sudmeyer M" first="Martin" last="Südmeyer">Martin Südmeyer</name><name sortKey="Thomalla, Gotz" sort="Thomalla, Gotz" uniqKey="Thomalla G" first="Götz" last="Thomalla">Götz Thomalla</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Franzkowiak, Stephanie" sort="Franzkowiak, Stephanie" uniqKey="Franzkowiak S" first="Stephanie" last="Franzkowiak">Stephanie Franzkowiak</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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