MovDisordV3, Pmc, Checkpoint, bibRecord, 000362

Calcium channel blocker use and risk of Parkinson’s disease

Identifieur interne : 000362 ( Pmc/Checkpoint ); précédent : 000361; suivant : 000363

Calcium channel blocker use and risk of Parkinson’s disease

Auteurs : K Claire Simon [États-Unis] ; Xiang Gao [États-Unis] ; Honglei Chen [États-Unis] ; Michael A. Schwarzschild [États-Unis] ; Alberto Ascherio [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.

RBID : PMC:2939261

Abstract

Purpose

To investigate whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson’s disease (PD) in two large prospective cohorts.

Methods

Prospective cohort study among participants in two ongoing studies – the Nurses’ Health Study (NHS) and Health Professionals’ Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders.

We identified 514 incident cases of PD during follow-up of individuals enrolled in the NHS and HPFS. No association between baseline use of CCBs (RR=1.18, 95% CI: 0.73, 1.92), frequency of use or duration of use of CCBs and PD risk was observed (P>0.2 for all).

Conclusions

These findings do no support a role for CCBs in providing neuroprotection against development of PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939261

DOI: 10.1002/mds.23191
PubMed: 20669249
PubMed Central: 2939261

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 000104
to stream Pmc, to step Curation: 000104

Links to Exploration step

PMC:2939261

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calcium channel blocker use and risk of Parkinson’s disease</title>
<author><name sortKey="Simon, K Claire" sort="Simon, K Claire" uniqKey="Simon K" first="K Claire" last="Simon">K Claire Simon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20669249</idno>
<idno type="pmc">2939261</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939261</idno>
<idno type="RBID">PMC:2939261</idno>
<idno type="doi">10.1002/mds.23191</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000104</idno>
<idno type="wicri:Area/Pmc/Curation">000104</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000362</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Calcium channel blocker use and risk of Parkinson’s disease</title>
<author><name sortKey="Simon, K Claire" sort="Simon, K Claire" uniqKey="Simon K" first="K Claire" last="Simon">K Claire Simon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Massachusetts General Hospital, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Nutrition, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Nutrition, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Epidemiology, Harvard School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, Harvard School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">To investigate whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson’s disease (PD) in two large prospective cohorts.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Prospective cohort study among participants in two ongoing studies – the Nurses’ Health Study (NHS) and Health Professionals’ Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders.</p>
<p id="P3">We identified 514 incident cases of PD during follow-up of individuals enrolled in the NHS and HPFS. No association between baseline use of CCBs (RR=1.18, 95% CI: 0.73, 1.92), frequency of use or duration of use of CCBs and PD risk was observed (P>0.2 for all).</p>
</sec>
<sec id="S3"><title>Conclusions</title>
<p id="P4">These findings do no support a role for CCBs in providing neuroprotection against development of PD.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20669249</article-id>
<article-id pub-id-type="pmc">2939261</article-id>
<article-id pub-id-type="doi">10.1002/mds.23191</article-id>
<article-id pub-id-type="manuscript">NIHMS195921</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Calcium channel blocker use and risk of Parkinson’s disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Simon</surname>
<given-names>K Claire</given-names>
</name>
<degrees>ScD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Xiang</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Honglei</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwarzschild</surname>
<given-names>Michael A</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ascherio</surname>
<given-names>Alberto</given-names>
</name>
<degrees>MD, DrPH</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Nutrition, Harvard School of Public Health, Boston, MA</aff>
<aff id="A2"><label>2</label>
Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA</aff>
<aff id="A3"><label>3</label>
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC</aff>
<aff id="A4"><label>4</label>
Department of Neurology, Massachusetts General Hospital, Boston, MA</aff>
<aff id="A5"><label>5</label>
Department of Epidemiology, Harvard School of Public Health, Boston, MA</aff>
<author-notes><corresp id="CR1">Corresponding author: Claire Simon – <email>ksimon@hsph.harvard.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>19</day>
<month>4</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>9</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>9</month>
<year>2011</year>
</pub-date>
<volume>25</volume>
<issue>12</issue>
<fpage>1818</fpage>
<lpage>1822</lpage>
<permissions><copyright-statement>© The Movement Disorder Society</copyright-statement>
</permissions>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">To investigate whether the use of calcium channel blockers (CCBs) was associated with a reduced risk of Parkinson’s disease (PD) in two large prospective cohorts.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Prospective cohort study among participants in two ongoing studies – the Nurses’ Health Study (NHS) and Health Professionals’ Follow-Up Study (HPFS). Cox proportional hazards models were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) to assess the association between use of CCBs and risk of PD adjusting for potential confounders.</p>
<p id="P3">We identified 514 incident cases of PD during follow-up of individuals enrolled in the NHS and HPFS. No association between baseline use of CCBs (RR=1.18, 95% CI: 0.73, 1.92), frequency of use or duration of use of CCBs and PD risk was observed (P>0.2 for all).</p>
</sec>
<sec id="S3"><title>Conclusions</title>
<p id="P4">These findings do no support a role for CCBs in providing neuroprotection against development of PD.</p>
</sec>
</abstract>
<contract-num rid="NS1">R01 NS048517-05
				||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke  : NINDS</contract-sponsor>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Massachusetts</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Simon, K Claire" sort="Simon, K Claire" uniqKey="Simon K" first="K Claire" last="Simon">K Claire Simon</name>
</region>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
<name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
<name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name>
<name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A" last="Schwarzschild">Michael A. Schwarzschild</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000362 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000362 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Pmc
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:2939261
   |texte=   Calcium channel blocker use and risk of Parkinson’s disease
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i   -Sk "pubmed:20669249" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Calcium channel blocker use and risk of Parkinson’s disease

Calcium channel blocker use and risk of Parkinson’s disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki