MovDisordV3, Ncbi, Merge, bibRecord, 002A49

DJ-1, PINK1 and their effects on Mitochondrial Pathways

Identifieur interne : 002A49 ( Ncbi/Merge ); précédent : 002A48; suivant : 002A50

DJ-1, PINK1 and their effects on Mitochondrial Pathways

Auteurs : Mark R. Cookson

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.

RBID : PMC:2840196

English descriptors

KwdEn :
- Animals, Genetic Predisposition to Disease, Humans, Intracellular Signaling Peptides and Proteins (genetics), Intracellular Signaling Peptides and Proteins (metabolism), Mitochondria (genetics), Mitochondria (metabolism), Mitochondria (pathology), Oncogene Proteins (genetics), Oncogene Proteins (metabolism), Oxidative Stress (physiology), Parkinsonian Disorders (genetics), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Protein Kinases (genetics), Protein Kinases (metabolism).
MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases.
- chemical , metabolism : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases.
- genetics : Mitochondria, Parkinsonian Disorders.
- metabolism : Mitochondria, Parkinsonian Disorders.
- pathology : Mitochondria, Parkinsonian Disorders.
- physiology : Oxidative Stress.
- Animals, Genetic Predisposition to Disease, Humans.

Abstract

Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson’s disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson’s disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840196

DOI: 10.1002/mds.22713
PubMed: 20187230
PubMed Central: 2840196

Links toward previous steps (curation, corpus...)

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to stream Pmc, to step Checkpoint: 000355
to stream PubMed, to step Corpus: 001953
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Links to Exploration step

PMC:2840196

Le document en format XML

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<front><div type="abstract" xml:lang="en">Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

DJ-1, PINK1 and their effects on Mitochondrial Pathways

DJ-1, PINK1 and their effects on Mitochondrial Pathways

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki