MovDisordV3, PubMed, Checkpoint, bibRecord, 001959

DJ-1, PINK1, and their effects on mitochondrial pathways.

Identifieur interne : 001959 ( PubMed/Checkpoint ); précédent : 001958; suivant : 001960

DJ-1, PINK1, and their effects on mitochondrial pathways.

Auteurs : Mark R. Cookson [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.

RBID : pubmed:20187230

English descriptors

KwdEn :
- Animals, Genetic Predisposition to Disease, Humans, Intracellular Signaling Peptides and Proteins (genetics), Intracellular Signaling Peptides and Proteins (metabolism), Mitochondria (genetics), Mitochondria (metabolism), Mitochondria (pathology), Oncogene Proteins (genetics), Oncogene Proteins (metabolism), Oxidative Stress (physiology), Parkinsonian Disorders (genetics), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Protein Kinases (genetics), Protein Kinases (metabolism).
MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases.
- chemical , metabolism : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases.
- genetics : Mitochondria, Parkinsonian Disorders.
- metabolism : Mitochondria, Parkinsonian Disorders.
- pathology : Mitochondria, Parkinsonian Disorders.
- physiology : Oxidative Stress.
- Animals, Genetic Predisposition to Disease, Humans.

Abstract

Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD.

DOI: 10.1002/mds.22713
PubMed: 20187230

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 001953
to stream PubMed, to step Curation: 001953

Links to Exploration step

pubmed:20187230

Le document en format XML

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<front><div type="abstract" xml:lang="en">Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD.</div>
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<NumberOfReferences>77</NumberOfReferences>
<OtherID Source="NLM">NIHMS146199</OtherID>
<OtherID Source="NLM">PMC2840196</OtherID>
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<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
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<tree><country name="États-Unis"><noRegion><name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R" last="Cookson">Mark R. Cookson</name>
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   |texte=   DJ-1, PINK1, and their effects on mitochondrial pathways.
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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

DJ-1, PINK1, and their effects on mitochondrial pathways.

DJ-1, PINK1, and their effects on mitochondrial pathways.

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