DJ-1, PINK1 and their effects on Mitochondrial Pathways
Identifieur interne : 000084 ( Pmc/Corpus ); précédent : 000083; suivant : 000085DJ-1, PINK1 and their effects on Mitochondrial Pathways
Auteurs : Mark R. CooksonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson’s disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ-1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson’s disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD.
Url:
DOI: 10.1002/mds.22713
PubMed: 20187230
PubMed Central: 2840196
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