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Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.

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Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.

Auteurs : Nebojsa M. Lali [Serbie] ; Natasa Dragasevi ; Elka Stefanova ; Aleksandra Joti ; Katarina Lali ; Tanja Milici ; Igor Petrovi ; Marija Ma Esi ; Vladimir S. Kosti

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.

RBID : pubmed:20669273

English descriptors

KwdEn :
- Blood Glucose (metabolism), Cholesterol, LDL (blood), Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin (metabolism), Insulin (secretion), Insulin Resistance, Spinocerebellar Ataxias (metabolism).
MESH :
- chemical , blood : Cholesterol, LDL.
- chemical , metabolism : Blood Glucose, Insulin.
- chemical , secretion : Insulin.
- metabolism : Spinocerebellar Ataxias.
- Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin Resistance.

Abstract

We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.

DOI: 10.1002/mds.23176
PubMed: 20669273

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pubmed:20669273

Le document en format XML

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<author><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojsa M" last="Lali">Nebojsa M. Lali</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia.</nlm:affiliation>
<country xml:lang="fr">Serbie</country>
<wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea>
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<author><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name>
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<author><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name>
</author>
<author><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name>
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<author><name sortKey="Milici, Tanja" sort="Milici, Tanja" uniqKey="Milici T" first="Tanja" last="Milici">Tanja Milici</name>
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<author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name>
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<author><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Esi">Marija Ma Esi</name>
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<author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S" last="Kosti">Vladimir S. Kosti</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.</title>
<author><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojsa M" last="Lali">Nebojsa M. Lali</name>
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<author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Natasa" last="Dragasevi">Natasa Dragasevi</name>
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<author><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name>
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<author><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name>
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<author><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name>
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<author><name sortKey="Milici, Tanja" sort="Milici, Tanja" uniqKey="Milici T" first="Tanja" last="Milici">Tanja Milici</name>
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<author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name>
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<author><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Esi">Marija Ma Esi</name>
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<author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S" last="Kosti">Vladimir S. Kosti</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Cholesterol, LDL (blood)</term>
<term>Glucose Clamp Technique</term>
<term>Glucose Tolerance Test</term>
<term>Humans</term>
<term>Insulin (metabolism)</term>
<term>Insulin (secretion)</term>
<term>Insulin Resistance</term>
<term>Spinocerebellar Ataxias (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol, LDL</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term>
<term>Insulin</term>
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<keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Insulin</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Spinocerebellar Ataxias</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Glucose Clamp Technique</term>
<term>Glucose Tolerance Test</term>
<term>Humans</term>
<term>Insulin Resistance</term>
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<front><div type="abstract" xml:lang="en">We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.</div>
</front>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.

Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.

Source :

English descriptors

Abstract

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Links to Exploration step

Le document en format XML

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Pour générer des pages wiki