Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.
Identifieur interne : 001689 ( PubMed/Curation ); précédent : 001688; suivant : 001690Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.
Auteurs : Nebojsa M. Lali [Serbie] ; Natasa Dragasevi ; Elka Stefanova ; Aleksandra Joti ; Katarina Lali ; Tanja Milici ; Igor Petrovi ; Marija Ma Esi ; Vladimir S. KostiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Cholesterol, LDL.
- chemical , metabolism : Blood Glucose, Insulin.
- chemical , secretion : Insulin.
- metabolism : Spinocerebellar Ataxias.
- Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin Resistance.
Abstract
We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.
DOI: 10.1002/mds.23176
PubMed: 20669273
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001689
Links to Exploration step
pubmed:20669273Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.</title><author><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojsa M" last="Lali">Nebojsa M. Lali</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Natasa" last="Dragasevi">Natasa Dragasevi</name></author><author><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name></author><author><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name></author><author><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name></author><author><name sortKey="Milici, Tanja" sort="Milici, Tanja" uniqKey="Milici T" first="Tanja" last="Milici">Tanja Milici</name></author><author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name></author><author><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Esi">Marija Ma Esi</name></author><author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S" last="Kosti">Vladimir S. Kosti</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23176</idno><idno type="RBID">pubmed:20669273</idno><idno type="pmid">20669273</idno><idno type="wicri:Area/PubMed/Corpus">001689</idno><idno type="wicri:Area/PubMed/Curation">001689</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.</title><author><name sortKey="Lali, Nebojsa M" sort="Lali, Nebojsa M" uniqKey="Lali N" first="Nebojsa M" last="Lali">Nebojsa M. Lali</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade</wicri:regionArea></affiliation></author><author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Natasa" last="Dragasevi">Natasa Dragasevi</name></author><author><name sortKey="Stefanova, Elka" sort="Stefanova, Elka" uniqKey="Stefanova E" first="Elka" last="Stefanova">Elka Stefanova</name></author><author><name sortKey="Joti, Aleksandra" sort="Joti, Aleksandra" uniqKey="Joti A" first="Aleksandra" last="Joti">Aleksandra Joti</name></author><author><name sortKey="Lali, Katarina" sort="Lali, Katarina" uniqKey="Lali K" first="Katarina" last="Lali">Katarina Lali</name></author><author><name sortKey="Milici, Tanja" sort="Milici, Tanja" uniqKey="Milici T" first="Tanja" last="Milici">Tanja Milici</name></author><author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name></author><author><name sortKey="Ma Esi, Marija" sort="Ma Esi, Marija" uniqKey="Ma Esi M" first="Marija" last="Ma Esi">Marija Ma Esi</name></author><author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S" last="Kosti">Vladimir S. Kosti</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Glucose (metabolism)</term><term>Cholesterol, LDL (blood)</term><term>Glucose Clamp Technique</term><term>Glucose Tolerance Test</term><term>Humans</term><term>Insulin (metabolism)</term><term>Insulin (secretion)</term><term>Insulin Resistance</term><term>Spinocerebellar Ataxias (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Spinocerebellar Ataxias</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Glucose Clamp Technique</term><term>Glucose Tolerance Test</term><term>Humans</term><term>Insulin Resistance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20669273</PMID><DateCreated><Year>2010</Year><Month>09</Month><Day>14</Day></DateCreated><DateCompleted><Year>2010</Year><Month>12</Month><Day>28</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>12</Issue><PubDate><Year>2010</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.</ArticleTitle><Pagination><MedlinePgn>1976-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23176</ELocationID><Abstract><AbstractText>We have recently shown an impairment in insulin sensitivity and insulin secretion in normoglycemic patients with Huntington disease (HD). To investigate whether such observations are HD-specific or may be common to other polyglutamine diseases, glucose homeostasis was studied in 12 unrelated, untreated normoglycemic patients with spinocerebellar ataxia type 1 (SCA1), another entity from the family of polyglutamine diseases, and 24 healthy, matched controls. Metabolic investigations included (a) glucose tolerance assessment on the basis of glucose curve during oral glucose challenge; (b) insulin sensitivity assessment by the homeostasis model assessment (HOMA) and the euglycemic insulin clamp (M value); and (c) insulin secretion by acute insulin response (AIR) and insulinogenic index. The evaluation of insulin sensitivity demonstrated higher HOMA-insulin resistance indices, and lower M values (P < 0.001 and P < 0.05, respectively), while both the AIR and the insulinogenic index were lower in patients with SCA1 compared to controls (P < 0.001 and P < 0.05, respectively). Our data suggested an impairment in insulin secretion capacity, as well as simultaneous decrease in insulin sensitivity, with an increase in insulin resistance level in patients with SCA1.</AbstractText><CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lalić</LastName><ForeName>Nebojsa M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Clinical Center of Serbia, Institute for Endocrinology, Diabetes and Metabolic Diseases, Belgrade, Serbia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dragasević</LastName><ForeName>Natasa</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Stefanova</LastName><ForeName>Elka</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Jotić</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lalić</LastName><ForeName>Katarina</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Milicić</LastName><ForeName>Tanja</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Petrović</LastName><ForeName>Igor</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Maćesić</LastName><ForeName>Marija</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kostić</LastName><ForeName>Vladimir S</ForeName><Initials>VS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001786">Blood Glucose</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008078">Cholesterol, LDL</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015309">Glucose Clamp Technique</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005951">Glucose Tolerance Test</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007328">Insulin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000557">secretion</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D007333">Insulin Resistance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020754">Spinocerebellar Ataxias</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>12</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.23176</ArticleId><ArticleId IdType="pubmed">20669273</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001689 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 001689 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:20669273
|texte= Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:20669273" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |