Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study.
Identifieur interne : 002D27 ( Ncbi/Curation ); précédent : 002D26; suivant : 002D28Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study.
Auteurs : Francesco Roselli [Italie] ; Nicola M. Pisciotta ; Michele Pennelli ; Maria S. Aniello ; Angelo Gigante ; Maria F. De Caro ; Ermanno Ferrannini ; Bruno Tartaglione ; Artor Niccoli-Asabella ; Giovanni Defazio ; Paolo Livrea ; Giuseppe RubiniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mesencephalon (metabolism), Mesencephalon (radionuclide imaging), Middle Aged, Movement Disorders (metabolism), Movement Disorders (radionuclide imaging), Serotonin Plasma Membrane Transport Proteins (metabolism).
- MESH :
- chemical , metabolism : Serotonin Plasma Membrane Transport Proteins.
- metabolism : Mesencephalon, Movement Disorders.
- radionuclide imaging : Mesencephalon, Movement Disorders.
- Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer (123)I-FP-CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer (123)I-FP-CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter-individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT-dependent (123)I-FP-CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis.
DOI: 10.1002/mds.23179
PubMed: 20669272
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Pisciotta</name></author><author><name sortKey="Pennelli, Michele" sort="Pennelli, Michele" uniqKey="Pennelli M" first="Michele" last="Pennelli">Michele Pennelli</name></author><author><name sortKey="Aniello, Maria S" sort="Aniello, Maria S" uniqKey="Aniello M" first="Maria S" last="Aniello">Maria S. Aniello</name></author><author><name sortKey="Gigante, Angelo" sort="Gigante, Angelo" uniqKey="Gigante A" first="Angelo" last="Gigante">Angelo Gigante</name></author><author><name sortKey="De Caro, Maria F" sort="De Caro, Maria F" uniqKey="De Caro M" first="Maria F" last="De Caro">Maria F. De Caro</name></author><author><name sortKey="Ferrannini, Ermanno" sort="Ferrannini, Ermanno" uniqKey="Ferrannini E" first="Ermanno" last="Ferrannini">Ermanno Ferrannini</name></author><author><name sortKey="Tartaglione, Bruno" sort="Tartaglione, Bruno" uniqKey="Tartaglione B" first="Bruno" last="Tartaglione">Bruno Tartaglione</name></author><author><name sortKey="Niccoli Asabella, Artor" sort="Niccoli Asabella, Artor" uniqKey="Niccoli Asabella A" first="Artor" last="Niccoli-Asabella">Artor Niccoli-Asabella</name></author><author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name></author><author><name sortKey="Livrea, Paolo" sort="Livrea, Paolo" uniqKey="Livrea P" first="Paolo" last="Livrea">Paolo Livrea</name></author><author><name sortKey="Rubini, Giuseppe" sort="Rubini, Giuseppe" uniqKey="Rubini G" first="Giuseppe" last="Rubini">Giuseppe Rubini</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23179</idno><idno type="RBID">pubmed:20669272</idno><idno type="pmid">20669272</idno><idno type="wicri:Area/PubMed/Corpus">001690</idno><idno type="wicri:Area/PubMed/Curation">001690</idno><idno type="wicri:Area/PubMed/Checkpoint">001780</idno><idno type="wicri:Area/Ncbi/Merge">002D27</idno><idno type="wicri:Area/Ncbi/Curation">002D27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study.</title><author><name sortKey="Roselli, Francesco" sort="Roselli, Francesco" uniqKey="Roselli F" first="Francesco" last="Roselli">Francesco Roselli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy. francesco_roselli@yahoo.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological and Psychiatric Sciences, University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Pisciotta, Nicola M" sort="Pisciotta, Nicola M" uniqKey="Pisciotta N" first="Nicola M" last="Pisciotta">Nicola M. Pisciotta</name></author><author><name sortKey="Pennelli, Michele" sort="Pennelli, Michele" uniqKey="Pennelli M" first="Michele" last="Pennelli">Michele Pennelli</name></author><author><name sortKey="Aniello, Maria S" sort="Aniello, Maria S" uniqKey="Aniello M" first="Maria S" last="Aniello">Maria S. Aniello</name></author><author><name sortKey="Gigante, Angelo" sort="Gigante, Angelo" uniqKey="Gigante A" first="Angelo" last="Gigante">Angelo Gigante</name></author><author><name sortKey="De Caro, Maria F" sort="De Caro, Maria F" uniqKey="De Caro M" first="Maria F" last="De Caro">Maria F. De Caro</name></author><author><name sortKey="Ferrannini, Ermanno" sort="Ferrannini, Ermanno" uniqKey="Ferrannini E" first="Ermanno" last="Ferrannini">Ermanno Ferrannini</name></author><author><name sortKey="Tartaglione, Bruno" sort="Tartaglione, Bruno" uniqKey="Tartaglione B" first="Bruno" last="Tartaglione">Bruno Tartaglione</name></author><author><name sortKey="Niccoli Asabella, Artor" sort="Niccoli Asabella, Artor" uniqKey="Niccoli Asabella A" first="Artor" last="Niccoli-Asabella">Artor Niccoli-Asabella</name></author><author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name></author><author><name sortKey="Livrea, Paolo" sort="Livrea, Paolo" uniqKey="Livrea P" first="Paolo" last="Livrea">Paolo Livrea</name></author><author><name sortKey="Rubini, Giuseppe" sort="Rubini, Giuseppe" uniqKey="Rubini G" first="Giuseppe" last="Rubini">Giuseppe Rubini</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mesencephalon (metabolism)</term><term>Mesencephalon (radionuclide imaging)</term><term>Middle Aged</term><term>Movement Disorders (metabolism)</term><term>Movement Disorders (radionuclide imaging)</term><term>Serotonin Plasma Membrane Transport Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Serotonin Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mesencephalon</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Mesencephalon</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SPECT imaging is widely used for the differential diagnosis of degenerative parkinsonisms by exploiting the high affinitiy of the radiotracer (123)I-FP-CIT for the dopamine transporter. Reduced levels of DAT are found in Parkinson Disease (PD), Dementia with Lewy Bodies (DLB), and Progressive Supranuclear Palsy (PSP) compared to in Essential Tremor (ET) and Healthy Controls (HC). However, the extent of the neurodegenerative process may extend beyond nigrostriatal system. We have exploited the affinity of the same radiotracer (123)I-FP-CIT for the serotonin transporter to investigate SERT levels in the midbrain of patients with PD, DLB, PSP, and ET compared to HC. Using MRI images as anatomical templates for midbrain uptake quantification, we found a mild decrease in SERT levels in PD compared to ET and HC, with marked inter-individual variability; on the other side, PSP and DLB patients displayed markedly reduced to undetectable levels of SERT, respectively. These findings show that the neurodegenerative process affects serotoninergic neurons in parkinsonisms, with much more severe involvement in DLB than in PD patients, despite the comparable loss of striatal DAT. SERT-dependent (123)I-FP-CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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