Basal ganglia physiology and deep brain stimulation.
Identifieur interne : 002A70 ( Ncbi/Checkpoint ); précédent : 002A69; suivant : 002A71Basal ganglia physiology and deep brain stimulation.
Auteurs : Andres M. Lozano [Canada] ; Brian J. Snyder ; Clement Hamani ; William D. Hutchison ; Jonathan O. DostrovskySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- methods : Deep Brain Stimulation.
- pathology : Basal Ganglia, Parkinson Disease.
- physiology : Action Potentials, Basal Ganglia, Neurons.
- therapy : Parkinson Disease.
- Animals, Humans.
Abstract
Despite improvements in anatomic imaging of the basal ganglia, microelectrode recording is still an invaluable tool in locating appropriate targets for neurosurgical intervention. These recording also provide an unparalleled opportunity to study the pathophysiological aspects of diseases. This article reviews the principles of microelectrode recording in functional neurosurgery and discusses the pathologic neurophysiologic findings commonly encountered. It also highlights some of the potential mechanisms of action of both dopaminergic drugs and deep brain stimulation. In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease.
DOI: 10.1002/mds.22714
PubMed: 20187251
Affiliations:
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pubmed:20187251Le document en format XML
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<wicri:regionArea>Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario</wicri:regionArea>
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<author><name sortKey="Snyder, Brian J" sort="Snyder, Brian J" uniqKey="Snyder B" first="Brian J" last="Snyder">Brian J. Snyder</name>
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<author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
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<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
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<term>Deep Brain Stimulation (methods)</term>
<term>Humans</term>
<term>Neurons (physiology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (therapy)</term>
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<front><div type="abstract" xml:lang="en">Despite improvements in anatomic imaging of the basal ganglia, microelectrode recording is still an invaluable tool in locating appropriate targets for neurosurgical intervention. These recording also provide an unparalleled opportunity to study the pathophysiological aspects of diseases. This article reviews the principles of microelectrode recording in functional neurosurgery and discusses the pathologic neurophysiologic findings commonly encountered. It also highlights some of the potential mechanisms of action of both dopaminergic drugs and deep brain stimulation. In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease.</div>
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<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
<name sortKey="Snyder, Brian J" sort="Snyder, Brian J" uniqKey="Snyder B" first="Brian J" last="Snyder">Brian J. Snyder</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
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