MovDisordV3, Ncbi, Checkpoint, bibRecord, 002A42

Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort

Identifieur interne : 002A42 ( Ncbi/Checkpoint ); précédent : 002A41; suivant : 002A43

Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort

Auteurs : Charles H. Adler [États-Unis] ; Donald J. Connor [États-Unis] ; Joseph G. Hentz [États-Unis] ; Marwan N. Sabbagh [États-Unis] ; John N. Caviness [États-Unis] ; Holly A. Shill [États-Unis] ; Brie Noble [États-Unis] ; Thomas G. Beach [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.

RBID : PMC:2935627

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Cohort Studies, Disability Evaluation, Female, Humans, Lewy Body Disease (diagnosis), Lewy Body Disease (physiopathology), Male, Neuropsychological Tests, Olfaction Disorders (diagnosis), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Retrospective Studies, Severity of Illness Index.
MESH :
- diagnosis : Lewy Body Disease, Olfaction Disorders, Parkinson Disease.
- physiopathology : Lewy Body Disease, Parkinson Disease.
- Aged, Aged, 80 and over, Cohort Studies, Disability Evaluation, Female, Humans, Male, Neuropsychological Tests, Retrospective Studies, Severity of Illness Index.

Abstract

Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson’s disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935627

DOI: 10.1002/mds.22971
PubMed: 20175211
PubMed Central: 2935627

Affiliations:

Links to Exploration step

PMC:2935627

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson’s disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.</p>
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Movement Disorders (revue)

Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort

Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort

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English descriptors

Abstract

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	Movement Disorders (revue)
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