Incidental Lewy body disease: clinical comparison to a control cohort.
Identifieur interne : 001960 ( PubMed/Corpus ); précédent : 001959; suivant : 001961Incidental Lewy body disease: clinical comparison to a control cohort.
Auteurs : Charles H. Adler ; Donald J. Connor ; Joseph G. Hentz ; Marwan N. Sabbagh ; John N. Caviness ; Holly A. Shill ; Brie Noble ; Thomas G. BeachSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cohort Studies, Disability Evaluation, Female, Humans, Lewy Body Disease (diagnosis), Lewy Body Disease (physiopathology), Male, Neuropsychological Tests, Olfaction Disorders (diagnosis), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Retrospective Studies, Severity of Illness Index.
- MESH :
- diagnosis : Lewy Body Disease, Olfaction Disorders, Parkinson Disease.
- physiopathology : Lewy Body Disease, Parkinson Disease.
- Aged, Aged, 80 and over, Cohort Studies, Disability Evaluation, Female, Humans, Male, Neuropsychological Tests, Retrospective Studies, Severity of Illness Index.
Abstract
Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.
DOI: 10.1002/mds.22971
PubMed: 20175211
Links to Exploration step
pubmed:20175211Le document en format XML
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Sabbagh</name></author><author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N" last="Caviness">John N. Caviness</name></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name></author><author><name sortKey="Noble, Brie" sort="Noble, Brie" uniqKey="Noble B" first="Brie" last="Noble">Brie Noble</name></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22971</idno><idno type="RBID">pubmed:20175211</idno><idno type="pmid">20175211</idno><idno type="wicri:Area/PubMed/Corpus">001960</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Incidental Lewy body disease: clinical comparison to a control cohort.</title><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation><nlm:affiliation>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona 85259, USA. cadler@mayo.edu</nlm:affiliation></affiliation></author><author><name sortKey="Connor, Donald J" sort="Connor, Donald J" uniqKey="Connor D" first="Donald J" last="Connor">Donald J. Connor</name></author><author><name sortKey="Hentz, Joseph G" sort="Hentz, Joseph G" uniqKey="Hentz J" first="Joseph G" last="Hentz">Joseph G. Hentz</name></author><author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N" last="Sabbagh">Marwan N. Sabbagh</name></author><author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N" last="Caviness">John N. Caviness</name></author><author><name sortKey="Shill, Holly A" sort="Shill, Holly A" uniqKey="Shill H" first="Holly A" last="Shill">Holly A. Shill</name></author><author><name sortKey="Noble, Brie" sort="Noble, Brie" uniqKey="Noble B" first="Brie" last="Noble">Brie Noble</name></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Lewy Body Disease (diagnosis)</term><term>Lewy Body Disease (physiopathology)</term><term>Male</term><term>Neuropsychological Tests</term><term>Olfaction Disorders (diagnosis)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lewy Body Disease</term><term>Olfaction Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lewy Body Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Neuropsychological Tests</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20175211</PMID><DateCreated><Year>2010</Year><Month>04</Month><Day>28</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>23</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Incidental Lewy body disease: clinical comparison to a control cohort.</ArticleTitle><Pagination><MedlinePgn>642-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22971</ELocationID><Abstract><AbstractText>Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.</AbstractText><CopyrightInformation>(c) 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Adler</LastName><ForeName>Charles H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona 85259, USA. cadler@mayo.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Connor</LastName><ForeName>Donald J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Hentz</LastName><ForeName>Joseph G</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>Sabbagh</LastName><ForeName>Marwan N</ForeName><Initials>MN</Initials></Author><Author ValidYN="Y"><LastName>Caviness</LastName><ForeName>John N</ForeName><Initials>JN</Initials></Author><Author ValidYN="Y"><LastName>Shill</LastName><ForeName>Holly A</ForeName><Initials>HA</Initials></Author><Author ValidYN="Y"><LastName>Noble</LastName><ForeName>Brie</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Beach</LastName><ForeName>Thomas G</ForeName><Initials>TG</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P30 AG019610</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AG019610</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AG019610-09</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2002 Dec;9(2):103-10</RefSource><PMID Version="1">12473400</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neuropathol. 2009 Jun;117(6):613-34</RefSource><PMID Version="1">19399512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neuropathol Exp Neurol. 2004 Jul;63(7):742-9</RefSource><PMID Version="1">15290899</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2004 Oct;56(4):532-9</RefSource><PMID Version="1">15389895</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neural Transm. 2004 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RefType="Cites"><RefSource>Cell Tissue Bank. 2008 Sep;9(3):229-45</RefSource><PMID Version="1">18347928</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2008 Aug;65(8):1074-80</RefSource><PMID Version="1">18695057</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2009 Mar 31;72(13):1121-6</RefSource><PMID Version="1">19020293</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Age Ageing. 1998 Sep;27(5):557-60</RefSource><PMID Version="1">12675093</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004185">Disability 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