Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort
Identifieur interne : 000083 ( Pmc/Curation ); précédent : 000082; suivant : 000084Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort
Auteurs : Charles H. Adler [États-Unis] ; Donald J. Connor [États-Unis] ; Joseph G. Hentz [États-Unis] ; Marwan N. Sabbagh [États-Unis] ; John N. Caviness [États-Unis] ; Holly A. Shill [États-Unis] ; Brie Noble [États-Unis] ; Thomas G. Beach [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson’s disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.
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DOI: 10.1002/mds.22971
PubMed: 20175211
PubMed Central: 2935627
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Hentz</name><affiliation wicri:level="1"><nlm:aff id="A3">Section of Biostatistics, Mayo Clinic, Scottsdale, Arizona, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Biostatistics, Mayo Clinic, Scottsdale, Arizona</wicri:regionArea></affiliation></author><author><name sortKey="Sabbagh, Marwan N" sort="Sabbagh, Marwan N" uniqKey="Sabbagh M" first="Marwan N." last="Sabbagh">Marwan N. Sabbagh</name><affiliation wicri:level="1"><nlm:aff id="A2">Sun Health Research Institute, Sun City, Arizona, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sun Health Research Institute, Sun City, Arizona</wicri:regionArea></affiliation></author><author><name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. 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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20175211</article-id><article-id pub-id-type="pmc">2935627</article-id><article-id pub-id-type="doi">10.1002/mds.22971</article-id><article-id pub-id-type="manuscript">NIHMS227979</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Incidental Lewy Body Disease: Clinical Comparison to a Control Cohort</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Adler</surname><given-names>Charles H.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Connor</surname><given-names>Donald J.</given-names></name><degrees>PhD, PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hentz</surname><given-names>Joseph G.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sabbagh</surname><given-names>Marwan N.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Caviness</surname><given-names>John N.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shill</surname><given-names>Holly A.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Noble</surname><given-names>Brie</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Beach</surname><given-names>Thomas G.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Parkinson’s Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona, USA</aff><aff id="A2"><label>2</label>Sun Health Research Institute, Sun City, Arizona, USA</aff><aff id="A3"><label>3</label>Section of Biostatistics, Mayo Clinic, Scottsdale, Arizona, USA</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Dr. Charles H. Adler; Parkinson’s Disease and Movement Disorders Center, Mayo Clinic Arizona, 13400 E. Shea Blvd., Scottsdale, AZ 85259, USA. <email>cadler@mayo.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>8</month><year>2010</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>8</day><month>9</month><year>2010</year></pub-date><volume>25</volume><issue>5</issue><fpage>642</fpage><lpage>646</lpage><permissions><copyright-statement>© 2010 Movement Disorder Society</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson’s disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.</p></abstract><kwd-group><kwd>incidental Lewy body disease</kwd><kwd>Lewy bodies</kwd><kwd>Parkinson’s disease</kwd><kwd>demential with Lewy bodies</kwd></kwd-group><contract-num rid="AG1">P30 AG019610-09
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