Motor patterns in Parkinson's disease: a data-driven approach.
Identifieur interne : 002608 ( Ncbi/Checkpoint ); précédent : 002607; suivant : 002609Motor patterns in Parkinson's disease: a data-driven approach.
Auteurs : Stephanie M. Van Rooden [Pays-Bas] ; Martine Visser ; Dagmar Verbaan ; Johan Marinus ; Jacobus J. Van HiltenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Databases, Bibliographic (statistics & numerical data), Disability Evaluation, Factor Analysis, Statistical, Humans, Longitudinal Studies, Movement (physiology), Neurologic Examination, Parkinson Disease (physiopathology), Psychometrics, Psychomotor Performance, Reference Values, Regression Analysis, Retrospective Studies, Severity of Illness Index.
- MESH :
- physiology : Movement.
- physiopathology : Parkinson Disease.
- statistics & numerical data : Databases, Bibliographic.
- Disability Evaluation, Factor Analysis, Statistical, Humans, Longitudinal Studies, Neurologic Examination, Psychometrics, Psychomotor Performance, Reference Values, Regression Analysis, Retrospective Studies, Severity of Illness Index.
Abstract
To identify patterns of motor disturbances in Parkinson's disease (PD) and evaluate their relation with other PD domains. A cohort of 399 PD patients was randomly divided into two samples. Factors within the motor section of the SPES/SCOPA were identified by exploratory factor analysis on data from the first sample and next tested by confirmatory factor analysis in the second sample. Relations with other PD domains were evaluated by regression analyses. A four factor model was found to be valid. This included a tremor, a bradykinetic-rigid, and two axial factors. One axial factor ("rise", "gait", "postural instability") was associated with age and cognition, while the other axial factor ("freezing", "speech", "swallowing") was related to dopaminergic medication and complications of therapy. Both other factors showed no relevant associations with demographic and clinical characteristics. The identification of motor factors and their relation with other domains of the disease may help to elucidate the mechanisms responsible for these associations and provide an objective base for further research on subtypes in PD.
DOI: 10.1002/mds.22512
PubMed: 19353712
Affiliations:
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Van Rooden</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. s.m.van_rooden@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Visser, Martine" sort="Visser, Martine" uniqKey="Visser M" first="Martine" last="Visser">Martine Visser</name></author><author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></author><author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name></author><author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. 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Van Rooden</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. s.m.van_rooden@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Visser, Martine" sort="Visser, Martine" uniqKey="Visser M" first="Martine" last="Visser">Martine Visser</name></author><author><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name></author><author><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name></author><author><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. Van Hilten</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Databases, Bibliographic (statistics & numerical data)</term><term>Disability Evaluation</term><term>Factor Analysis, Statistical</term><term>Humans</term><term>Longitudinal Studies</term><term>Movement (physiology)</term><term>Neurologic Examination</term><term>Parkinson Disease (physiopathology)</term><term>Psychometrics</term><term>Psychomotor Performance</term><term>Reference Values</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Bibliographic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disability Evaluation</term><term>Factor Analysis, Statistical</term><term>Humans</term><term>Longitudinal Studies</term><term>Neurologic Examination</term><term>Psychometrics</term><term>Psychomotor Performance</term><term>Reference Values</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify patterns of motor disturbances in Parkinson's disease (PD) and evaluate their relation with other PD domains. A cohort of 399 PD patients was randomly divided into two samples. Factors within the motor section of the SPES/SCOPA were identified by exploratory factor analysis on data from the first sample and next tested by confirmatory factor analysis in the second sample. Relations with other PD domains were evaluated by regression analyses. A four factor model was found to be valid. This included a tremor, a bradykinetic-rigid, and two axial factors. One axial factor ("rise", "gait", "postural instability") was associated with age and cognition, while the other axial factor ("freezing", "speech", "swallowing") was related to dopaminergic medication and complications of therapy. Both other factors showed no relevant associations with demographic and clinical characteristics. The identification of motor factors and their relation with other domains of the disease may help to elucidate the mechanisms responsible for these associations and provide an objective base for further research on subtypes in PD.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Leyde</li></settlement></list><tree><noCountry><name sortKey="Marinus, Johan" sort="Marinus, Johan" uniqKey="Marinus J" first="Johan" last="Marinus">Johan Marinus</name><name sortKey="Van Hilten, Jacobus J" sort="Van Hilten, Jacobus J" uniqKey="Van Hilten J" first="Jacobus J" last="Van Hilten">Jacobus J. Van Hilten</name><name sortKey="Verbaan, Dagmar" sort="Verbaan, Dagmar" uniqKey="Verbaan D" first="Dagmar" last="Verbaan">Dagmar Verbaan</name><name sortKey="Visser, Martine" sort="Visser, Martine" uniqKey="Visser M" first="Martine" last="Visser">Martine Visser</name></noCountry><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Rooden, Stephanie M" sort="Van Rooden, Stephanie M" uniqKey="Van Rooden S" first="Stephanie M" last="Van Rooden">Stephanie M. Van Rooden</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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