Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia.
Identifieur interne : 002607 ( Ncbi/Checkpoint ); précédent : 002606; suivant : 002608Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia.
Auteurs : Stefano Zoccolella [Italie] ; Claudia Dell'Aquila ; Giovanni Abruzzese ; Angelo Antonini ; Ubaldo Bonuccelli ; Margherita Canesi ; Silvano Cristina ; Roberta Marchese ; Claudio Pacchetti ; Roberto Zagaglia ; Giancarlo Logroscino ; Giovanni Defazio ; Paolo Lamberti ; Paolo LivreaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Antiparkinson Agents (adverse effects), Case-Control Studies, Chromatography, High Pressure Liquid (methods), Cross-Sectional Studies, Dementia (blood), Dementia (complications), Dementia (drug therapy), Female, Homocysteine (blood), Humans, Hyperhomocysteinemia (chemically induced), Levodopa (adverse effects), Levodopa (therapeutic use), Logistic Models, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Parkinson Disease (blood), Parkinson Disease (complications), Parkinson Disease (drug therapy).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- blood : Dementia, Homocysteine, Parkinson Disease.
- chemically induced : Hyperhomocysteinemia.
- complications : Dementia, Parkinson Disease.
- drug therapy : Dementia, Parkinson Disease.
- methods : Chromatography, High Pressure Liquid.
- chemical , therapeutic use : Levodopa.
- Aged, Analysis of Variance, Case-Control Studies, Cross-Sectional Studies, Female, Humans, Logistic Models, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests.
Abstract
Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age- and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 micromol/L +/- 10.2 vs. 11 +/- 4.1; P < 0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 micromol/L +/- 12.1 vs. 15.8 +/- 8.5; P = 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 micromol/L) with the bottom tertile (<12.4 micromol/L): 3.68; 95% CI: 1.14-11.83] were significantly associated with dementia. These data support the association between elevated Hcy levels and the presence of dementia in PD.
DOI: 10.1002/mds.22511
PubMed: 19353704
Affiliations:
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<front><div type="abstract" xml:lang="en">Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age- and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 micromol/L +/- 10.2 vs. 11 +/- 4.1; P < 0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 micromol/L +/- 12.1 vs. 15.8 +/- 8.5; P = 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 micromol/L) with the bottom tertile (<12.4 micromol/L): 3.68; 95% CI: 1.14-11.83] were significantly associated with dementia. These data support the association between elevated Hcy levels and the presence of dementia in PD.</div>
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