Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease
Identifieur interne : 005C85 ( Main/Merge ); précédent : 005C84; suivant : 005C86Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease
Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno [Japon] ; Ikuko Mizuta [Japon] ; Mitsuhiro Ohta [Japon] ; Hirofumi Maruyama [Japon] ; Ryuji Kaji [Japon] ; Hideshi Kawakami [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-08.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Chemokine CCL2.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease, Polymorphism, Genetic.
- Adult, Age of Onset, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Middle Aged.
Abstract
We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10462
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Kawakami</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-08">2003-08</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="953">953</biblScope><biblScope unit="page" to="955">955</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">03E3FE011DF143E4C2692E5BAF52E16C492C7779</idno><idno type="DOI">10.1002/mds.10462</idno><idno type="ArticleID">MDS10462</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>CCR‐2</term><term>Chemokine CCL2 (genetics)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>MCP‐1</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson's disease</term><term>Polymorphism, Genetic (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokine CCL2</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. 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sortKey="Mizuta, Ikuko" sort="Mizuta, Ikuko" uniqKey="Mizuta I" first="Ikuko" last="Mizuta">Ikuko Mizuta</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Clinical Research Center, Utano National Hospital, Kyoto</wicri:regionArea><wicri:noRegion>Kyoto</wicri:noRegion></affiliation></author><author><name sortKey="Ohta, Mitsuhiro" sort="Ohta, Mitsuhiro" uniqKey="Ohta M" first="Mitsuhiro" last="Ohta">Mitsuhiro Ohta</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Chemistry, Kobe Pharmaceutical University, Kobe</wicri:regionArea><wicri:noRegion>Kobe</wicri:noRegion></affiliation></author><author><name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-08">2003-08</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="953">953</biblScope><biblScope unit="page" to="955">955</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">03E3FE011DF143E4C2692E5BAF52E16C492C7779</idno><idno type="DOI">10.1002/mds.10462</idno><idno type="ArticleID">MDS10462</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CCR‐2</term><term>MCP‐1</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease.</title><author><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan. mnishim@clin.tokushima-u.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name></author><author><name sortKey="Mizuta, Ikuko" sort="Mizuta, Ikuko" uniqKey="Mizuta I" first="Ikuko" last="Mizuta">Ikuko Mizuta</name></author><author><name sortKey="Ohta, Mitsuhiro" sort="Ohta, Mitsuhiro" uniqKey="Ohta M" first="Mitsuhiro" last="Ohta">Mitsuhiro Ohta</name></author><author><name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name></author><author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12889089</idno><idno type="pmid">12889089</idno><idno type="doi">10.1002/mds.10462</idno><idno 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Neuroscience, Tokushima University Hospital, Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name></author><author><name sortKey="Mizuta, Ikuko" sort="Mizuta, Ikuko" uniqKey="Mizuta I" first="Ikuko" last="Mizuta">Ikuko Mizuta</name></author><author><name sortKey="Ohta, Mitsuhiro" sort="Ohta, Mitsuhiro" uniqKey="Ohta M" first="Mitsuhiro" last="Ohta">Mitsuhiro Ohta</name></author><author><name sortKey="Maruyama, Hirofumi" sort="Maruyama, Hirofumi" uniqKey="Maruyama H" first="Hirofumi" last="Maruyama">Hirofumi Maruyama</name></author><author><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name></author><author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Chemokine CCL2 (genetics)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokine CCL2</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP-1) and CC chemokine receptor (CCR)-2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP-1 -2518A/G genotype affected the age-at-onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP-1 in PD.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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