Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease
Identifieur interne : 002992 ( Istex/Checkpoint ); précédent : 002991; suivant : 002993Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease
Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno [Japon] ; Ikuko Mizuta [Japon] ; Mitsuhiro Ohta [Japon] ; Hirofumi Maruyama [Japon] ; Ryuji Kaji [Japon] ; Hideshi Kawakami [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-08.
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Abstract
We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10462
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ISTEX:03E3FE011DF143E4C2692E5BAF52E16C492C7779Le document en format XML
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<front><div type="abstract" xml:lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society</div>
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