Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease
Identifieur interne : 001A83 ( Istex/Corpus ); précédent : 001A82; suivant : 001A84Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease
Auteurs : Masataka Nishimura ; Sadako Kuno ; Ikuko Mizuta ; Mitsuhiro Ohta ; Hirofumi Maruyama ; Ryuji Kaji ; Hideshi KawakamiSource :
- Movement Disorders [ 0885-3185 ] ; 2003-08.
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- KwdEn :
Abstract
We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10462
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ISTEX:03E3FE011DF143E4C2692E5BAF52E16C492C7779Le document en format XML
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Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MCP‐1 and PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Masataka</namePart><namePart type="family">Nishimura</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan</affiliation><description>Correspondence: Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima 770‐8503, Japan</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sadako</namePart><namePart type="family">Kuno</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Research Center, Utano National Hospital, Kyoto, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ikuko</namePart><namePart type="family">Mizuta</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Clinical Research Center, Utano National Hospital, Kyoto, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mitsuhiro</namePart><namePart type="family">Ohta</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Clinical Chemistry, Kobe Pharmaceutical University, Kobe, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hirofumi</namePart><namePart type="family">Maruyama</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ryuji</namePart><namePart type="family">Kaji</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hideshi</namePart><namePart type="family">Kawakami</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">shortCommunication</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-08</dateIssued><dateCaptured encoding="w3cdtf">2002-08-24</dateCaptured><dateValid encoding="w3cdtf">2003-01-15</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">2</extent><extent unit="references">11</extent><extent unit="words">2112</extent></physicalDescription><abstract lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>MCP‐1</topic><topic>CCR‐2</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Clinical/Scientific Note</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>953</start><end>955</end><total>3</total></extent></part></relatedItem><identifier type="istex">03E3FE011DF143E4C2692E5BAF52E16C492C7779</identifier><identifier type="DOI">10.1002/mds.10462</identifier><identifier type="ArticleID">MDS10462</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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