Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
Identifieur interne : 005708 ( Main/Merge ); précédent : 005707; suivant : 005709Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
Auteurs : Gregor K. Wenning [Autriche] ; Franc Ois Tison [France] ; Klaus Seppi [Autriche] ; Cristina Sampaio [Portugal] ; Anja Diem [Autriche] ; Farid Yekhlef [France] ; Imad Ghorayeb [France] ; Fabienne Ory [France] ; Monique Galitzky [France] ; Tommaso Scaravilli [Royaume-Uni] ; Maria Bozi [Royaume-Uni] ; Carlo Colosimo [Italie] ; Sid Gilman [États-Unis] ; Clifford W. Shults [États-Unis] ; Niall P. Quinn [Royaume-Uni] ; Olivier Rascol [France] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-12.
English descriptors
- KwdEn :
- Activities of Daily Living, Age of Onset, Autonomic Nervous System (physiopathology), Cerebellar Ataxia (epidemiology), Disability Evaluation, Erectile Dysfunction (epidemiology), Female, Humans, Hypotension, Orthostatic (epidemiology), Male, Multiple System Atrophy (diagnosis), Multiple System Atrophy (epidemiology), Multiple System Atrophy (physiopathology), Observer Variation, Parkinsonian Disorders (epidemiology), Questionnaires, Reproducibility of Results, Severity of Illness Index, Speech Disorders (epidemiology), Unified Multiple System Atrophy Rating Scale, Urinary Incontinence (epidemiology), Urinary Retention (epidemiology), internal consistency, interrater reliability, validation.
- MESH :
- diagnosis : Multiple System Atrophy.
- epidemiology : Cerebellar Ataxia, Erectile Dysfunction, Hypotension, Orthostatic, Multiple System Atrophy, Parkinsonian Disorders, Speech Disorders, Urinary Incontinence, Urinary Retention.
- physiopathology : Autonomic Nervous System, Multiple System Atrophy.
- Activities of Daily Living, Age of Onset, Disability Evaluation, Female, Humans, Male, Observer Variation, Questionnaires, Reproducibility of Results, Severity of Illness Index.
Abstract
We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale ‐ UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS‐I (Crohnbach's alpha = 0.84) and UMSARS‐II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS‐I and ‐II items as well as of total UMSARS‐I and ‐II subscores was substantial (k (w) = 0.6–0.8) to excellent (k (w) > 0.8). UMSARS‐II correlated well with UPDRS‐III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20255
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ISTEX:2C01987595DEF441D78B1D1D9A34624282EBF9BALe document en format XML
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<term>Multiple System Atrophy (diagnosis)</term>
<term>Multiple System Atrophy (epidemiology)</term>
<term>Multiple System Atrophy (physiopathology)</term>
<term>Observer Variation</term>
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<term>Questionnaires</term>
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<front><div type="abstract" xml:lang="en">We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale ‐ UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS‐I (Crohnbach's alpha = 0.84) and UMSARS‐II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS‐I and ‐II items as well as of total UMSARS‐I and ‐II subscores was substantial (k (w) = 0.6–0.8) to excellent (k (w) > 0.8). UMSARS‐II correlated well with UPDRS‐III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients. © 2004 Movement Disorder Society</div>
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<author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. Shults</name>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
</author>
<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<placeName><settlement type="city">Toulouse</settlement>
<region type="region" nuts="2">Midi-Pyrénées</region>
</placeName>
<orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
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<idno type="doi">10.1002/mds.20255</idno>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)</title>
<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tison, Franc Ois" sort="Tison, Franc Ois" uniqKey="Tison F" first="Franc Ois" last="Tison">Franc Ois Tison</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Hopital du Haut‐Leveque, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name>
<affiliation wicri:level="1"><country xml:lang="fr">Portugal</country>
<wicri:regionArea>Faculdade de Medicine de Lisboa, Hospital Santa Maria, Centro de Neurosciencas, Lisboa</wicri:regionArea>
<wicri:noRegion>Lisboa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Hopital du Haut‐Leveque, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghorayeb, Imad" sort="Ghorayeb, Imad" uniqKey="Ghorayeb I" first="Imad" last="Ghorayeb">Imad Ghorayeb</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Hopital du Haut‐Leveque, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University College London, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University College London, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name>
<affiliation wicri:level="4"><country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Neurologiche, Universita' La Sapienza, Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
<orgName type="university">Université de Rome « La Sapienza »</orgName>
</affiliation>
</author>
<author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. Shults</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University College London, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
</placeName>
<placeName><settlement type="city">Toulouse</settlement>
<region type="region" nuts="2">Midi-Pyrénées</region>
</placeName>
<orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName>
</affiliation>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2004-12">2004-12</date>
<biblScope unit="vol">19</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="1391">1391</biblScope>
<biblScope unit="page" to="1402">1402</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">2C01987595DEF441D78B1D1D9A34624282EBF9BA</idno>
<idno type="DOI">10.1002/mds.20255</idno>
<idno type="ArticleID">MDS20255</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Unified Multiple System Atrophy Rating Scale</term>
<term>internal consistency</term>
<term>interrater reliability</term>
<term>validation</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
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<front><div type="abstract" xml:lang="en">We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale ‐ UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS‐I (Crohnbach's alpha = 0.84) and UMSARS‐II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS‐I and ‐II items as well as of total UMSARS‐I and ‐II subscores was substantial (k (w) = 0.6–0.8) to excellent (k (w) > 0.8). UMSARS‐II correlated well with UPDRS‐III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients. © 2004 Movement Disorder Society</div>
</front>
</TEI>
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<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS).</title>
<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Innsbruck, Austria. gregor.wenning@uibk.ac.at</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
</author>
<author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name>
</author>
<author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name>
</author>
<author><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name>
</author>
<author><name sortKey="Ghorayeb, Imad" sort="Ghorayeb, Imad" uniqKey="Ghorayeb I" first="Imad" last="Ghorayeb">Imad Ghorayeb</name>
</author>
<author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
</author>
<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
</author>
<author><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name>
</author>
<author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name>
</author>
<author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name>
</author>
<author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name>
</author>
<author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W" last="Shults">Clifford W. Shults</name>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P" last="Quinn">Niall P. Quinn</name>
</author>
<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
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<author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K" last="Wenning">Gregor K. Wenning</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Innsbruck, Austria. gregor.wenning@uibk.ac.at</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea>
<wicri:noRegion>University of Innsbruck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name>
</author>
<author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name>
</author>
<author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name>
</author>
<author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name>
</author>
<author><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name>
</author>
<author><name sortKey="Ghorayeb, Imad" sort="Ghorayeb, Imad" uniqKey="Ghorayeb I" first="Imad" last="Ghorayeb">Imad Ghorayeb</name>
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<author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name>
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<author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name>
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<author><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name>
</author>
<author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name>
</author>
<author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name>
</author>
<author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name>
</author>
<author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W" last="Shults">Clifford W. Shults</name>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P" last="Quinn">Niall P. Quinn</name>
</author>
<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
</author>
<author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name>
<affiliation><country>Autriche</country>
<placeName><settlement type="city">Innsbruck</settlement>
<region nuts="2" type="region">Tyrol (Land)</region>
</placeName>
<orgName type="university">Université de médecine d'Innsbruck</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term>
<term>Age of Onset</term>
<term>Autonomic Nervous System (physiopathology)</term>
<term>Cerebellar Ataxia (epidemiology)</term>
<term>Disability Evaluation</term>
<term>Erectile Dysfunction (epidemiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Hypotension, Orthostatic (epidemiology)</term>
<term>Male</term>
<term>Multiple System Atrophy (diagnosis)</term>
<term>Multiple System Atrophy (epidemiology)</term>
<term>Multiple System Atrophy (physiopathology)</term>
<term>Observer Variation</term>
<term>Parkinsonian Disorders (epidemiology)</term>
<term>Questionnaires</term>
<term>Reproducibility of Results</term>
<term>Severity of Illness Index</term>
<term>Speech Disorders (epidemiology)</term>
<term>Urinary Incontinence (epidemiology)</term>
<term>Urinary Retention (epidemiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cerebellar Ataxia</term>
<term>Erectile Dysfunction</term>
<term>Hypotension, Orthostatic</term>
<term>Multiple System Atrophy</term>
<term>Parkinsonian Disorders</term>
<term>Speech Disorders</term>
<term>Urinary Incontinence</term>
<term>Urinary Retention</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Autonomic Nervous System</term>
<term>Multiple System Atrophy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term>
<term>Age of Onset</term>
<term>Disability Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Observer Variation</term>
<term>Questionnaires</term>
<term>Reproducibility of Results</term>
<term>Severity of Illness Index</term>
</keywords>
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<front><div type="abstract" xml:lang="en">We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale-UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-I (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k(w) = 0.6-0.8) to excellent (k(w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.</div>
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