Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
Identifieur interne : 005709 ( Main/Merge ); précédent : 005708; suivant : 005710Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
Auteurs : Ulrike Sommer [Allemagne] ; Thomas Hummel [Allemagne] ; Katja Cormann [Allemagne] ; Antje Mueller [Allemagne] ; Johannes Frasnelli [Allemagne] ; Joachim Kropp [Allemagne] ; Heinz Reichmann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
English descriptors
- KwdEn :
- Adult, Aged, Echoencephalography (methods), Female, Humans, Iodine Radioisotopes (diagnostic use), Male, Middle Aged, Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Predictive Value of Tests, Prospective Studies, Radiopharmaceuticals (diagnostic use), Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), neurodegeneration, olfaction, predictor, smell, transcranial sonography.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Radiopharmaceuticals, Tropanes.
- complications : Parkinson Disease.
- diagnosis : Olfaction Disorders, Parkinson Disease.
- etiology : Olfaction Disorders.
- methods : Echoencephalography.
- Adult, Aged, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon.
Abstract
Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether “idiopathic” olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with 123I‐FP‐CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow‐up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20141
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<front><div type="abstract" xml:lang="en">Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether “idiopathic” olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with 123I‐FP‐CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow‐up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future. © 2004 Movement Disorder Society</div>
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<idno type="wicri:doubleKey">0885-3185:2004:Sommer U:detection:of:presymptomatic</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Detection of presymptomatic Parkinson's disease: combining smell tests, transcranial sonography, and SPECT.</title>
<author><name sortKey="Sommer, Ulrike" sort="Sommer, Ulrike" uniqKey="Sommer U" first="Ulrike" last="Sommer">Ulrike Sommer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Dresden Medical School, Dresden, Germany. sommer-uli@web.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Dresden Medical School, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hummel, Thomas" sort="Hummel, Thomas" uniqKey="Hummel T" first="Thomas" last="Hummel">Thomas Hummel</name>
</author>
<author><name sortKey="Cormann, Katja" sort="Cormann, Katja" uniqKey="Cormann K" first="Katja" last="Cormann">Katja Cormann</name>
</author>
<author><name sortKey="Mueller, Antje" sort="Mueller, Antje" uniqKey="Mueller A" first="Antje" last="Mueller">Antje Mueller</name>
</author>
<author><name sortKey="Frasnelli, Johannes" sort="Frasnelli, Johannes" uniqKey="Frasnelli J" first="Johannes" last="Frasnelli">Johannes Frasnelli</name>
</author>
<author><name sortKey="Kropp, Joachim" sort="Kropp, Joachim" uniqKey="Kropp J" first="Joachim" last="Kropp">Joachim Kropp</name>
</author>
<author><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
</biblStruct>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Echoencephalography (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Iodine Radioisotopes (diagnostic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Olfaction Disorders (diagnosis)</term>
<term>Olfaction Disorders (etiology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Predictive Value of Tests</term>
<term>Prospective Studies</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
<term>Severity of Illness Index</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tropanes (diagnostic use)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term>
<term>Radiopharmaceuticals</term>
<term>Tropanes</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Olfaction Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Echoencephalography</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Prospective Studies</term>
<term>Severity of Illness Index</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether "idiopathic" olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with (123)I-FP-CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow-up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future.</div>
</front>
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