Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
Identifieur interne : 000613 ( Istex/Curation ); précédent : 000612; suivant : 000614Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)
Auteurs : Gregor K. Wenning [Autriche] ; Franc Ois Tison [France] ; Klaus Seppi [Autriche] ; Cristina Sampaio [Portugal] ; Anja Diem [Autriche] ; Farid Yekhlef [France] ; Imad Ghorayeb [France] ; Fabienne Ory [France] ; Monique Galitzky [France] ; Tommaso Scaravilli [Royaume-Uni] ; Maria Bozi [Royaume-Uni] ; Carlo Colosimo [Italie] ; Sid Gilman [États-Unis] ; Clifford W. Shults [États-Unis] ; Niall P. Quinn [Royaume-Uni] ; Olivier Rascol [France] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-12.
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Abstract
We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale ‐ UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS‐I (Crohnbach's alpha = 0.84) and UMSARS‐II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS‐I and ‐II items as well as of total UMSARS‐I and ‐II subscores was substantial (k (w) = 0.6–0.8) to excellent (k (w) > 0.8). UMSARS‐II correlated well with UPDRS‐III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients. © 2004 Movement Disorder Society
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DOI: 10.1002/mds.20255
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Sapienza, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche, Universita' La Sapienza, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. 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Wenning</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Tison, Franc Ois" sort="Tison, Franc Ois" uniqKey="Tison F" first="Franc Ois" last="Tison">Franc Ois Tison</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, Hopital du Haut‐Leveque, Pessac, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Hopital du Haut‐Leveque, Pessac</wicri:regionArea></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Sampaio, Cristina" sort="Sampaio, Cristina" uniqKey="Sampaio C" first="Cristina" last="Sampaio">Cristina Sampaio</name><affiliation wicri:level="1"><mods:affiliation>Faculdade de Medicine de Lisboa, Hospital Santa Maria, Centro de Neurosciencas, Lisboa, Portugal</mods:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Medicine de Lisboa, Hospital Santa Maria, Centro de Neurosciencas, Lisboa</wicri:regionArea></affiliation></author><author><name sortKey="Diem, Anja" sort="Diem, Anja" uniqKey="Diem A" first="Anja" last="Diem">Anja Diem</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea></affiliation></author><author><name sortKey="Yekhlef, Farid" sort="Yekhlef, Farid" uniqKey="Yekhlef F" first="Farid" last="Yekhlef">Farid Yekhlef</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, Hopital du Haut‐Leveque, Pessac, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Hopital du Haut‐Leveque, Pessac</wicri:regionArea></affiliation></author><author><name sortKey="Ghorayeb, Imad" sort="Ghorayeb, Imad" uniqKey="Ghorayeb I" first="Imad" last="Ghorayeb">Imad Ghorayeb</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, Hopital du Haut‐Leveque, Pessac, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, Hopital du Haut‐Leveque, Pessac</wicri:regionArea></affiliation></author><author><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name><affiliation wicri:level="1"><mods:affiliation>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Galitzky, Monique" sort="Galitzky, Monique" uniqKey="Galitzky M" first="Monique" last="Galitzky">Monique Galitzky</name><affiliation wicri:level="1"><mods:affiliation>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Scaravilli, Tommaso" sort="Scaravilli, Tommaso" uniqKey="Scaravilli T" first="Tommaso" last="Scaravilli">Tommaso Scaravilli</name><affiliation wicri:level="1"><mods:affiliation>University College London, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><mods:affiliation>University College London, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation wicri:level="1"><mods:affiliation>Dipartimento di Scienze Neurologiche, Universita' La Sapienza, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Neurologiche, Universita' La Sapienza, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Gilman, Sid" sort="Gilman, Sid" uniqKey="Gilman S" first="Sid" last="Gilman">Sid Gilman</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea></affiliation></author><author><name sortKey="Shults, Clifford W" sort="Shults, Clifford W" uniqKey="Shults C" first="Clifford W." last="Shults">Clifford W. Shults</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, University of California San Diego School of Medicine, La Jolla, California</wicri:regionArea></affiliation></author><author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><affiliation wicri:level="1"><mods:affiliation>University College London, Institute of Neurology, Queen Square, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Institute of Neurology, Queen Square, London</wicri:regionArea></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><mods:affiliation>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Toulouse III University, Laboratoire de Pharmacologie, Faculte de Medecine, Toulouse</wicri:regionArea></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Innsbruck, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, University of Innsbruck</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-12">2004-12</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1391">1391</biblScope><biblScope unit="page" to="1402">1402</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2C01987595DEF441D78B1D1D9A34624282EBF9BA</idno><idno type="DOI">10.1002/mds.20255</idno><idno type="ArticleID">MDS20255</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Unified Multiple System Atrophy Rating Scale</term><term>internal consistency</term><term>interrater reliability</term><term>validation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale ‐ UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS‐I (Crohnbach's alpha = 0.84) and UMSARS‐II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS‐I and ‐II items as well as of total UMSARS‐I and ‐II subscores was substantial (k (w) = 0.6–0.8) to excellent (k (w) > 0.8). UMSARS‐II correlated well with UPDRS‐III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients. © 2004 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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