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Atypical Parkinsonism combining α-synuclein inclusions and polyglucosan body disease

Identifieur interne : 005404 ( Main/Merge ); précédent : 005403; suivant : 005405

Atypical Parkinsonism combining α-synuclein inclusions and polyglucosan body disease

Auteurs : Elsa Krim [France] ; Anne Vital [France] ; Frederic Macia [France] ; Farid Yekhlef [France] ; Francois Tison [France]

Source :

Movement disorders [ 0885-3185 ] ; 2005.

RBID : Pascal:05-0151000

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Corps inclusion, Parkinsonisme.

English descriptors

KwdEn :
- Inclusion body, Nervous system diseases, Parkinsonism.

Abstract

Adult polyglucosan body disease (APGBD) is a rare disorder affecting the central and peripheral nervous systems and in which parkinsonism is unusual. A 71-year-old man presented levodopa-unresponsive parkinsonism with urinary incontinence and recurrent syncopes of 6 years standing masquerading as atypical parkinsonism of the multiple system atrophy (MSA-P) type. Brain histopathology demonstrated massive accumulation of polyglucosan bodies particularly in the putamen. In addition, there were dense α-synuclein-positive cytoplasmic oligodendroglial inclusions in the pons and in the middle cerebellar peduncle. These inclusions may be either due to the chance association of MSA-P with APGBD, or pathologically related to APGBD.

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Pascal:05-0151000

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Atypical Parkinsonism combining α-synuclein inclusions and polyglucosan body disease</title>
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<series><title level="j" type="main">Movement disorders</title>
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<front><div type="abstract" xml:lang="en">Adult polyglucosan body disease (APGBD) is a rare disorder affecting the central and peripheral nervous systems and in which parkinsonism is unusual. A 71-year-old man presented levodopa-unresponsive parkinsonism with urinary incontinence and recurrent syncopes of 6 years standing masquerading as atypical parkinsonism of the multiple system atrophy (MSA-P) type. Brain histopathology demonstrated massive accumulation of polyglucosan bodies particularly in the putamen. In addition, there were dense α-synuclein-positive cytoplasmic oligodendroglial inclusions in the pons and in the middle cerebellar peduncle. These inclusions may be either due to the chance association of MSA-P with APGBD, or pathologically related to APGBD.</div>
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<tree><country name="France"><noRegion><name sortKey="Krim, Elsa" sort="Krim, Elsa" uniqKey="Krim E" first="Elsa" last="Krim">Elsa Krim</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Atypical Parkinsonism combining α-synuclein inclusions and polyglucosan body disease

Atypical Parkinsonism combining α-synuclein inclusions and polyglucosan body disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri