MovDisordV3, Main, Merge, bibRecord, 004364

Axonal excitability properties in hemifacial spasm

Identifieur interne : 004364 ( Main/Merge ); précédent : 004363; suivant : 004365

Axonal excitability properties in hemifacial spasm

Auteurs : Arun V. Krishnan [Australie] ; Michael Hayes [Australie] ; Matthew C. Kiernan [Australie]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0391080

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Hémispasme facial, Excitabilité, Nerf facial, Electrotonus.

English descriptors

KwdEn :
- Electrotonus, Excitability, Facial nerve, Hemifacial spasm, Nervous system diseases.

Abstract

Hemifacial spasm (HFS) is characterized by involuntary, irregular contractions of muscles innervated by the facial nerve. Whether the facial nerve has a relative predisposition for ectopic activity has not been clarified. Nerve excitability techniques, which provide information about membrane potential and axonal ion channel function, were initially measured in 12 control subjects looking for biophysical differences that may predispose the facial nerve to generate ectopic activity. In a second series of studies, facial nerve excitability was assessed in nine HFS patients. In both series, stimulus-response behavior, threshold electrotonus, a current threshold relationship, and the recovery of excitability following supramaximal stimulation were recorded following stimulation of the facial nerve. When compared to normative data from nerves in the upper and lower limbs, there was a relative "fanning-in" of threshold electrotonus, reduced superexcitability, and increased subexcitability in facial nerve studies from control subjects (P < 0.05), consistent with relative axonal depolarization. These findings may underlie the propensity for the facial nerve to develop ectopic impulse activity in motor axons. In the HFS patient study, there were no significant differences in distal facial nerve excitability properties from the affected side in HFS patients when compared either to the unaffected side or to normative facial nerve data. It is concluded that the impulse generator underlying HFS must consequently be sited more proximally and does not cause a generalized disturbance of motor axon excitability.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001616
to stream PascalFrancis, to step Curation: 001705
to stream PascalFrancis, to step Checkpoint: 001774

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Pascal:07-0391080

Le document en format XML

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<front><div type="abstract" xml:lang="en">Hemifacial spasm (HFS) is characterized by involuntary, irregular contractions of muscles innervated by the facial nerve. Whether the facial nerve has a relative predisposition for ectopic activity has not been clarified. Nerve excitability techniques, which provide information about membrane potential and axonal ion channel function, were initially measured in 12 control subjects looking for biophysical differences that may predispose the facial nerve to generate ectopic activity. In a second series of studies, facial nerve excitability was assessed in nine HFS patients. In both series, stimulus-response behavior, threshold electrotonus, a current threshold relationship, and the recovery of excitability following supramaximal stimulation were recorded following stimulation of the facial nerve. When compared to normative data from nerves in the upper and lower limbs, there was a relative "fanning-in" of threshold electrotonus, reduced superexcitability, and increased subexcitability in facial nerve studies from control subjects (P < 0.05), consistent with relative axonal depolarization. These findings may underlie the propensity for the facial nerve to develop ectopic impulse activity in motor axons. In the HFS patient study, there were no significant differences in distal facial nerve excitability properties from the affected side in HFS patients when compared either to the unaffected side or to normative facial nerve data. It is concluded that the impulse generator underlying HFS must consequently be sited more proximally and does not cause a generalized disturbance of motor axon excitability.</div>
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<name sortKey="Hayes, Michael" sort="Hayes, Michael" uniqKey="Hayes M" first="Michael" last="Hayes">Michael Hayes</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Axonal excitability properties in hemifacial spasm

Axonal excitability properties in hemifacial spasm

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri