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Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy

Identifieur interne : 004363 ( Main/Merge ); précédent : 004362; suivant : 004364

Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy

Auteurs : Naomi M. Warren [Royaume-Uni] ; Margaret A. Piggott [Royaume-Uni] ; Elizabeth Greally [Royaume-Uni] ; Michelle Lake [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; David J. Burn [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0448795

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Noyau gris central.

English descriptors

KwdEn :
- Basal ganglion, Nervous system diseases.

Abstract

Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder. In contrast to Parkinson's disease (PD) and dementia with Lewy bodies (DLB), replacement therapy with dopaminergic and cholinergic agents in PSP has been disappointing. The neurochemical basis for this is unclear. Our objective was to measure dopaminergic and cholinergic receptors in the basal ganglia of PSP and control brains. We measured, autoradiographically, dopaminergic (dopamine transporter, ¹²⁵I PE2I and dopamine D2 receptors, ¹²⁵I epidepride) and cholinergic (nicotinic α4β2 receptors, ¹²⁵I 5IA85380 and muscarinic Ml receptors, ³H pirenzepine) parameters in the striatum and pallidum of pathologically confirmed PSP cases (n = 15) and controls (n = 32). In PSP, there was a marked loss of dopamine transporter and nicotinic α4β2 binding in the striatum and pallidum, consistent with loss of nigrostriatal neurones. Striatal D2 receptors were increased in the caudate and muscarinic Ml receptors were unchanged compared with controls. These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors.

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Pascal:07-0448795

Le document en format XML

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<front><div type="abstract" xml:lang="en">Progressive Supranuclear Palsy (PSP) is a progressive neurodegenerative disorder. In contrast to Parkinson's disease (PD) and dementia with Lewy bodies (DLB), replacement therapy with dopaminergic and cholinergic agents in PSP has been disappointing. The neurochemical basis for this is unclear. Our objective was to measure dopaminergic and cholinergic receptors in the basal ganglia of PSP and control brains. We measured, autoradiographically, dopaminergic (dopamine transporter, <sup>125</sup>
I PE2I and dopamine D2 receptors, <sup>125</sup>
I epidepride) and cholinergic (nicotinic α4β2 receptors, <sup>125</sup>
I 5IA85380 and muscarinic Ml receptors, <sup>3</sup>
H pirenzepine) parameters in the striatum and pallidum of pathologically confirmed PSP cases (n = 15) and controls (n = 32). In PSP, there was a marked loss of dopamine transporter and nicotinic α4β2 binding in the striatum and pallidum, consistent with loss of nigrostriatal neurones. Striatal D2 receptors were increased in the caudate and muscarinic Ml receptors were unchanged compared with controls. These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors.</div>
</front>
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<name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David J." last="Burn">David J. Burn</name>
<name sortKey="Greally, Elizabeth" sort="Greally, Elizabeth" uniqKey="Greally E" first="Elizabeth" last="Greally">Elizabeth Greally</name>
<name sortKey="Lake, Michelle" sort="Lake, Michelle" uniqKey="Lake M" first="Michelle" last="Lake">Michelle Lake</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Piggott, Margaret A" sort="Piggott, Margaret A" uniqKey="Piggott M" first="Margaret A." last="Piggott">Margaret A. Piggott</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy

Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri