Acute ataxia, Graves' disease, and stiff person syndrome
Identifieur interne : 003F56 ( Main/Merge ); précédent : 003F55; suivant : 003F57Acute ataxia, Graves' disease, and stiff person syndrome
Auteurs : Su-Ynn Chia [Singapour] ; Richard Chua [Singapour] ; Yew-Long Lo [Singapour] ; Meng-Cheong Wong [Singapour] ; Ling-Ling Chan [Singapour] ; Eng-King Tan [Singapour]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-10-15.
English descriptors
- KwdEn :
- Antithyroid Agents (administration & dosage), Ataxia (diagnosis), Ataxia (immunology), Ataxia (therapy), Autoantibodies (blood), Carbimazole (administration & dosage), Combined Modality Therapy, Comorbidity, Diagnosis, Differential, Electromyography, Female, Glutamate Decarboxylase (immunology), Graves Disease (diagnosis), Graves Disease (immunology), Graves Disease (therapy), Graves' disease, Humans, Immunization, Passive, Immunosuppression, Middle Aged, Neurologic Examination, Plasmapheresis, Stiff-Person Syndrome (diagnosis), Stiff-Person Syndrome (immunology), Stiff-Person Syndrome (therapy), Stroke (diagnosis), Thyrotoxicosis (diagnosis), Thyrotoxicosis (immunology), Thyrotoxicosis (therapy), ataxia, stiff person syndrome.
- MESH :
- chemical , administration & dosage : Antithyroid Agents, Carbimazole.
- chemical , blood : Autoantibodies.
- diagnosis : Ataxia, Graves Disease, Stiff-Person Syndrome, Stroke, Thyrotoxicosis.
- immunology : Ataxia, Glutamate Decarboxylase, Graves Disease, Stiff-Person Syndrome, Thyrotoxicosis.
- therapy : Ataxia, Graves Disease, Stiff-Person Syndrome, Thyrotoxicosis.
- Combined Modality Therapy, Comorbidity, Diagnosis, Differential, Electromyography, Female, Humans, Immunization, Passive, Immunosuppression, Middle Aged, Neurologic Examination, Plasmapheresis.
Abstract
Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow‐up period of 3 years. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21703
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<front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow‐up period of 3 years. © 2007 Movement Disorder Society</div>
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<term>Thyrotoxicosis (diagnosis)</term>
<term>Thyrotoxicosis (immunology)</term>
<term>Thyrotoxicosis (therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antithyroid Agents</term>
<term>Carbimazole</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Ataxia</term>
<term>Graves Disease</term>
<term>Stiff-Person Syndrome</term>
<term>Stroke</term>
<term>Thyrotoxicosis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Ataxia</term>
<term>Glutamate Decarboxylase</term>
<term>Graves Disease</term>
<term>Stiff-Person Syndrome</term>
<term>Thyrotoxicosis</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Ataxia</term>
<term>Graves Disease</term>
<term>Stiff-Person Syndrome</term>
<term>Thyrotoxicosis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term>
<term>Comorbidity</term>
<term>Diagnosis, Differential</term>
<term>Electromyography</term>
<term>Female</term>
<term>Humans</term>
<term>Immunization, Passive</term>
<term>Immunosuppression</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Plasmapheresis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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