Acute ataxia, Graves' disease, and stiff person syndrome.
Identifieur interne : 001E08 ( Ncbi/Checkpoint ); précédent : 001E07; suivant : 001E09Acute ataxia, Graves' disease, and stiff person syndrome.
Auteurs : Su-Ynn Chia [Singapour] ; Richard Chua ; Yew-Long Lo ; Meng-Cheong Wong ; Ling-Ling Chan ; Eng-King TanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Antithyroid Agents (administration & dosage), Ataxia (diagnosis), Ataxia (immunology), Ataxia (therapy), Autoantibodies (blood), Carbimazole (administration & dosage), Combined Modality Therapy, Comorbidity, Diagnosis, Differential, Electromyography, Female, Glutamate Decarboxylase (immunology), Graves Disease (diagnosis), Graves Disease (immunology), Graves Disease (therapy), Humans, Immunization, Passive, Immunosuppression, Middle Aged, Neurologic Examination, Plasmapheresis, Stiff-Person Syndrome (diagnosis), Stiff-Person Syndrome (immunology), Stiff-Person Syndrome (therapy), Stroke (diagnosis), Thyrotoxicosis (diagnosis), Thyrotoxicosis (immunology), Thyrotoxicosis (therapy).
- MESH :
- chemical , administration & dosage : Antithyroid Agents, Carbimazole.
- chemical , blood : Autoantibodies.
- diagnosis : Ataxia, Graves Disease, Stiff-Person Syndrome, Stroke, Thyrotoxicosis.
- immunology : Ataxia, Glutamate Decarboxylase, Graves Disease, Stiff-Person Syndrome, Thyrotoxicosis.
- therapy : Ataxia, Graves Disease, Stiff-Person Syndrome, Thyrotoxicosis.
- Combined Modality Therapy, Comorbidity, Diagnosis, Differential, Electromyography, Female, Humans, Immunization, Passive, Immunosuppression, Middle Aged, Neurologic Examination, Plasmapheresis.
Abstract
Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years.
DOI: 10.1002/mds.21703
PubMed: 17712846
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute ataxia, Graves' disease, and stiff person syndrome.</title><author><name sortKey="Chia, Su Ynn" sort="Chia, Su Ynn" uniqKey="Chia S" first="Su-Ynn" last="Chia">Su-Ynn Chia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Neurology, National Neuroscience Institute, Singapore General Hospital</wicri:regionArea><wicri:noRegion>Singapore General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Chua, Richard" sort="Chua, Richard" uniqKey="Chua R" first="Richard" last="Chua">Richard Chua</name></author><author><name sortKey="Lo, Yew Long" sort="Lo, Yew Long" uniqKey="Lo Y" first="Yew-Long" last="Lo">Yew-Long Lo</name></author><author><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name></author><author><name sortKey="Chan, Ling Ling" sort="Chan, Ling Ling" uniqKey="Chan L" first="Ling-Ling" last="Chan">Ling-Ling Chan</name></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21703</idno><idno type="RBID">pubmed:17712846</idno><idno type="pmid">17712846</idno><idno type="wicri:Area/PubMed/Corpus">002551</idno><idno type="wicri:Area/PubMed/Curation">002551</idno><idno type="wicri:Area/PubMed/Checkpoint">002992</idno><idno type="wicri:Area/Ncbi/Merge">001E08</idno><idno type="wicri:Area/Ncbi/Curation">001E08</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Acute ataxia, Graves' disease, and stiff person syndrome.</title><author><name sortKey="Chia, Su Ynn" sort="Chia, Su Ynn" uniqKey="Chia S" first="Su-Ynn" last="Chia">Su-Ynn Chia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Department of Neurology, National Neuroscience Institute, Singapore General Hospital</wicri:regionArea><wicri:noRegion>Singapore General Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Chua, Richard" sort="Chua, Richard" uniqKey="Chua R" first="Richard" last="Chua">Richard Chua</name></author><author><name sortKey="Lo, Yew Long" sort="Lo, Yew Long" uniqKey="Lo Y" first="Yew-Long" last="Lo">Yew-Long Lo</name></author><author><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name></author><author><name sortKey="Chan, Ling Ling" sort="Chan, Ling Ling" uniqKey="Chan L" first="Ling-Ling" last="Chan">Ling-Ling Chan</name></author><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antithyroid Agents (administration & dosage)</term><term>Ataxia (diagnosis)</term><term>Ataxia (immunology)</term><term>Ataxia (therapy)</term><term>Autoantibodies (blood)</term><term>Carbimazole (administration & dosage)</term><term>Combined Modality Therapy</term><term>Comorbidity</term><term>Diagnosis, Differential</term><term>Electromyography</term><term>Female</term><term>Glutamate Decarboxylase (immunology)</term><term>Graves Disease (diagnosis)</term><term>Graves Disease (immunology)</term><term>Graves Disease (therapy)</term><term>Humans</term><term>Immunization, Passive</term><term>Immunosuppression</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Plasmapheresis</term><term>Stiff-Person Syndrome (diagnosis)</term><term>Stiff-Person Syndrome (immunology)</term><term>Stiff-Person Syndrome (therapy)</term><term>Stroke (diagnosis)</term><term>Thyrotoxicosis (diagnosis)</term><term>Thyrotoxicosis (immunology)</term><term>Thyrotoxicosis (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antithyroid Agents</term><term>Carbimazole</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Ataxia</term><term>Graves Disease</term><term>Stiff-Person Syndrome</term><term>Stroke</term><term>Thyrotoxicosis</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Ataxia</term><term>Glutamate Decarboxylase</term><term>Graves Disease</term><term>Stiff-Person Syndrome</term><term>Thyrotoxicosis</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Ataxia</term><term>Graves Disease</term><term>Stiff-Person Syndrome</term><term>Thyrotoxicosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term><term>Comorbidity</term><term>Diagnosis, Differential</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Immunization, Passive</term><term>Immunosuppression</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Plasmapheresis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stiff person syndrome (SPS) has been associated with autoimmune diseases, such as Type 1 diabetes mellitus and autoimmune thyroid disease (Hashimoto's thyroiditis), among others. The association of SPS with hyperthyroidism is extremely rare. We describe a patient with uncontrolled Graves' disease and undiagnosed SPS, who presented initially with acute ataxia simulating a cerebrovascular accident. Initiation of immunosuppressive therapy dramatically improved the patient's Graves' disease within 2 weeks but the neurological symptoms were not alleviated after a follow-up period of 3 years.</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><noCountry><name sortKey="Chan, Ling Ling" sort="Chan, Ling Ling" uniqKey="Chan L" first="Ling-Ling" last="Chan">Ling-Ling Chan</name><name sortKey="Chua, Richard" sort="Chua, Richard" uniqKey="Chua R" first="Richard" last="Chua">Richard Chua</name><name sortKey="Lo, Yew Long" sort="Lo, Yew Long" uniqKey="Lo Y" first="Yew-Long" last="Lo">Yew-Long Lo</name><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><name sortKey="Wong, Meng Cheong" sort="Wong, Meng Cheong" uniqKey="Wong M" first="Meng-Cheong" last="Wong">Meng-Cheong Wong</name></noCountry><country name="Singapour"><noRegion><name sortKey="Chia, Su Ynn" sort="Chia, Su Ynn" uniqKey="Chia S" first="Su-Ynn" last="Chia">Su-Ynn Chia</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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