MovDisordV3, Main, Merge, bibRecord, 003C85

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Identifieur interne : 003C85 ( Main/Merge ); précédent : 003C84; suivant : 003C86

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Auteurs : Xuemei Huang [États-Unis] ; Honglei Chen [États-Unis] ; William C. Miller [États-Unis] ; Richard B. Mailman [États-Unis] ; Jennifer L. Woodard [États-Unis] ; Peter C. Chen [États-Unis] ; Dong Xiang [États-Unis] ; Richard W. Murrow [États-Unis] ; Yi-Zhe Wang [États-Unis] ; Charles Poole [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-02-15.

RBID : ISTEX:3E1B153FFB67B36435A859DC843CB60184B7D47D

English descriptors

KwdEn :
- Aged, Case-Control Studies, Cholesterol, LDL (metabolism), Female, Humans, Male, Middle Aged, Odds Ratio, Parkinson Disease (metabolism), Parkinson's disease, apolipoprotein E, case control study, low‐density lipoprotein cholesterol, statin.
MESH :
- chemical , metabolism : Cholesterol, LDL.
- metabolism : Parkinson Disease.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Odds Ratio.

Abstract

The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society

Url:

DOI: 10.1002/mds.21290

Links to Exploration step

ISTEX:3E1B153FFB67B36435A859DC843CB60184B7D47D

Le document en format XML

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<front><div type="abstract" xml:lang="en">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society</div>
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<placeName><region type="state">Caroline du Nord</region>
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<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lower low density lipid cholesterol levels are associated with Parkinson’s disease</title>
<author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
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<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
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<placeName><region type="state">Caroline du Nord</region>
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<author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A4"> Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7160</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Woodard, Jennifer L" sort="Woodard, Jennifer L" uniqKey="Woodard J" first="Jennifer L." last="Woodard">Jennifer L. Woodard</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Chen, Peter C" sort="Chen, Peter C" uniqKey="Chen P" first="Peter C." last="Chen">Peter C. Chen</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Xiang, Dong" sort="Xiang, Dong" uniqKey="Xiang D" first="Dong" last="Xiang">Dong Xiang</name>
<affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
</affiliation>
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<author><name sortKey="Murrow, Richard W" sort="Murrow, Richard W" uniqKey="Murrow R" first="Richard W." last="Murrow">Richard W. Murrow</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Yi Zhe" sort="Wang, Yi Zhe" uniqKey="Wang Y" first="Yi-Zhe" last="Wang">Yi-Zhe Wang</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Poole, Charles" sort="Poole, Charles" uniqKey="Poole C" first="Charles" last="Poole">Charles Poole</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
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<imprint><date when="2007">2007</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Case-Control Studies</term>
<term>Cholesterol, LDL (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Parkinson Disease (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol, LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.</p>
</div>
</front>
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Movement Disorders (revue)

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

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	Movement Disorders (revue)
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