Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease
Identifieur interne : 003C85 ( Main/Merge ); précédent : 003C84; suivant : 003C86Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease
Auteurs : Xuemei Huang [États-Unis] ; Honglei Chen [États-Unis] ; William C. Miller [États-Unis] ; Richard B. Mailman [États-Unis] ; Jennifer L. Woodard [États-Unis] ; Peter C. Chen [États-Unis] ; Dong Xiang [États-Unis] ; Richard W. Murrow [États-Unis] ; Yi-Zhe Wang [États-Unis] ; Charles Poole [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-02-15.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Cholesterol, LDL.
- metabolism : Parkinson Disease.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Odds Ratio.
Abstract
The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society
Url:
- https://api.istex.fr/document/3E1B153FFB67B36435A859DC843CB60184B7D47D/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906875
DOI: 10.1002/mds.21290
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ISTEX:3E1B153FFB67B36435A859DC843CB60184B7D47DLe document en format XML
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<front><div type="abstract" xml:lang="en">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society</div>
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<placeName><region type="state">Caroline du Nord</region>
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<wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
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<wicri:cityArea> Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea>
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<author><name sortKey="Wang, Yi Zhe" sort="Wang, Yi Zhe" uniqKey="Wang Y" first="Yi-Zhe" last="Wang">Yi-Zhe Wang</name>
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<placeName><region type="state">Caroline du Nord</region>
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<country xml:lang="fr">États-Unis</country>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Parkinson Disease (metabolism)</term>
</keywords>
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<term>Case-Control Studies</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.</p>
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