Lower low density lipid cholesterol levels are associated with Parkinson’s disease
Identifieur interne : 000456 ( Pmc/Checkpoint ); précédent : 000455; suivant : 000457Lower low density lipid cholesterol levels are associated with Parkinson’s disease
Auteurs : Xuemei Huang [États-Unis] ; Honglei Chen [États-Unis] ; William C. Miller [États-Unis] ; Richard B. Mailman [États-Unis] ; Jennifer L. Woodard [États-Unis] ; Peter C. Chen [États-Unis] ; Dong Xiang [États-Unis] ; Richard W. Murrow [États-Unis] ; Yi-Zhe Wang [États-Unis] ; Charles Poole [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
Abstract
The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.
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DOI: 10.1002/mds.21290
PubMed: 17177184
PubMed Central: 1906875
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Miller</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Epidemiology (WCM, CP), School of Public Health, University of North Carolina, Chapel Hill, NC 27599</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Epidemiology (WCM, CP), School of Public Health, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7160</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Woodard, Jennifer L" sort="Woodard, Jennifer L" uniqKey="Woodard J" first="Jennifer L." last="Woodard">Jennifer L. Woodard</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Peter C" sort="Chen, Peter C" uniqKey="Chen P" first="Peter C." last="Chen">Peter C. Chen</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Xiang, Dong" sort="Xiang, Dong" uniqKey="Xiang D" first="Dong" last="Xiang">Dong Xiang</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Murrow, Richard W" sort="Murrow, Richard W" uniqKey="Murrow R" first="Richard W." last="Murrow">Richard W. Murrow</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Wang, Yi Zhe" sort="Wang, Yi Zhe" uniqKey="Wang Y" first="Yi-Zhe" last="Wang">Yi-Zhe Wang</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Poole, Charles" sort="Poole, Charles" uniqKey="Poole C" first="Charles" last="Poole">Charles Poole</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Epidemiology (WCM, CP), School of Public Health, University of North Carolina, Chapel Hill, NC 27599</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea> Department of Epidemiology (WCM, CP), School of Public Health, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17177184</article-id><article-id pub-id-type="pmc">1906875</article-id><article-id pub-id-type="doi">10.1002/mds.21290</article-id><article-id pub-id-type="manuscript">NIHMS19068</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Lower low density lipid cholesterol levels are associated with Parkinson’s disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Xuemei</given-names></name><degrees>MD, PhD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Honglei</given-names></name><degrees>MD, PhD</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Miller</surname><given-names>William C.</given-names></name><degrees>MD, PhD, MPH</degrees><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Mailman</surname><given-names>Richard B.</given-names></name><degrees>PhD.</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Woodard</surname><given-names>Jennifer L.</given-names></name><degrees>BS</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Peter C.</given-names></name><degrees>BS</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Xiang</surname><given-names>Dong</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Murrow</surname><given-names>Richard W.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yi-Zhe</given-names></name><degrees>MD, PhD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Poole</surname><given-names>Charles</given-names></name><degrees>MPH, ScD.</degrees><xref rid="A3" ref-type="aff">3</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</aff><aff id="A2"><label>2</label> National Institute of Environmental Health Sciences (HC), Research Triangle Park, NC 27709</aff><aff id="A3"><label>3</label> Department of Epidemiology (WCM, CP), School of Public Health, University of North Carolina, Chapel Hill, NC 27599</aff><aff id="A4"><label>4</label> Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7160</aff><author-notes><corresp id="FN1">Correspondence Xuemei Huang MD, PhD, Department of Neurology, 3104 Bioinformatics Building, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7025, Voice: 919-966-5549 Fax: 919-966-2922, Email: <email>xuemei@med.unc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>5</month><year>2007</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>2</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>5</day><month>7</month><year>2007</year></pub-date><volume>22</volume><issue>3</issue><fpage>377</fpage><lpage>381</lpage><abstract><p id="P1">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.</p></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>LDL cholesterol</kwd><kwd>apolipoprotein E</kwd><kwd>statin</kwd><kwd>case control study</kwd></kwd-group><contract-num rid="CS1">M01 RR000046-41</contract-num><contract-num rid="CS1">001-0418-609</contract-num><contract-num rid="CS1">K23 AG021491-04</contract-num><contract-sponsor id="CS1">National Institutes of Health</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name></region><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><name sortKey="Chen, Peter C" sort="Chen, Peter C" uniqKey="Chen P" first="Peter C." last="Chen">Peter C. Chen</name><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name><name sortKey="Miller, William C" sort="Miller, William C" uniqKey="Miller W" first="William C." last="Miller">William C. Miller</name><name sortKey="Murrow, Richard W" sort="Murrow, Richard W" uniqKey="Murrow R" first="Richard W." last="Murrow">Richard W. Murrow</name><name sortKey="Poole, Charles" sort="Poole, Charles" uniqKey="Poole C" first="Charles" last="Poole">Charles Poole</name><name sortKey="Wang, Yi Zhe" sort="Wang, Yi Zhe" uniqKey="Wang Y" first="Yi-Zhe" last="Wang">Yi-Zhe Wang</name><name sortKey="Woodard, Jennifer L" sort="Woodard, Jennifer L" uniqKey="Woodard J" first="Jennifer L." last="Woodard">Jennifer L. Woodard</name><name sortKey="Xiang, Dong" sort="Xiang, Dong" uniqKey="Xiang D" first="Dong" last="Xiang">Dong Xiang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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