Lower low density lipid cholesterol levels are associated with Parkinson’s disease
Identifieur interne : 000456 ( Pmc/Checkpoint ); précédent : 000455; suivant : 000457Lower low density lipid cholesterol levels are associated with Parkinson’s disease
Auteurs : Xuemei Huang [États-Unis] ; Honglei Chen [États-Unis] ; William C. Miller [États-Unis] ; Richard B. Mailman [États-Unis] ; Jennifer L. Woodard [États-Unis] ; Peter C. Chen [États-Unis] ; Dong Xiang [États-Unis] ; Richard W. Murrow [États-Unis] ; Yi-Zhe Wang [États-Unis] ; Charles Poole [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
Abstract
The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.
Url:
DOI: 10.1002/mds.21290
PubMed: 17177184
PubMed Central: 1906875
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.</p>
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<title-group><article-title>Lower low density lipid cholesterol levels are associated with Parkinson’s disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Xuemei</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Honglei</given-names>
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<degrees>MD, PhD</degrees>
<xref rid="A2" ref-type="aff">2</xref>
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<contrib contrib-type="author"><name><surname>Miller</surname>
<given-names>William C.</given-names>
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<degrees>MD, PhD, MPH</degrees>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mailman</surname>
<given-names>Richard B.</given-names>
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<degrees>PhD.</degrees>
<xref rid="A1" ref-type="aff">1</xref>
<xref rid="A4" ref-type="aff">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woodard</surname>
<given-names>Jennifer L.</given-names>
</name>
<degrees>BS</degrees>
<xref rid="A1" ref-type="aff">1</xref>
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<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Peter C.</given-names>
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<contrib contrib-type="author"><name><surname>Xiang</surname>
<given-names>Dong</given-names>
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<contrib contrib-type="author"><name><surname>Murrow</surname>
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<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Yi-Zhe</given-names>
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<degrees>MD, PhD</degrees>
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<contrib contrib-type="author"><name><surname>Poole</surname>
<given-names>Charles</given-names>
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<degrees>MPH, ScD.</degrees>
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<aff id="A1"><label>1</label>
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7025</aff>
<aff id="A2"><label>2</label>
National Institute of Environmental Health Sciences (HC), Research Triangle Park, NC 27709</aff>
<aff id="A3"><label>3</label>
Department of Epidemiology (WCM, CP), School of Public Health, University of North Carolina, Chapel Hill, NC 27599</aff>
<aff id="A4"><label>4</label>
Departments of Pharmacology, Psychiatry, and Medicinal Chemistry, Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7160</aff>
<author-notes><corresp id="FN1">Correspondence Xuemei Huang MD, PhD, Department of Neurology, 3104 Bioinformatics Building, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7025, Voice: 919-966-5549 Fax: 919-966-2922, Email: <email>xuemei@med.unc.edu</email>
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<pub-date pub-type="nihms-submitted"><day>2</day>
<month>5</month>
<year>2007</year>
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<pub-date pub-type="ppub"><day>15</day>
<month>2</month>
<year>2007</year>
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<pub-date pub-type="pmc-release"><day>5</day>
<month>7</month>
<year>2007</year>
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<volume>22</volume>
<issue>3</issue>
<fpage>377</fpage>
<lpage>381</lpage>
<abstract><p id="P1">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson’s disease (PD) and lower low density lipoprotein cholesterol (LDL-C). The study is to test the hypothesis that lower LDL-C may be associated with PD. This case-control study used fasting lipid profiles obtained from 124 PD cases and 110 controls, the PD cases recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and controls recruited from the spouse populations of the same clinic. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol-lowering agents. Lower LDL-C concentrations were associated with a higher prevalence of PD. Compared with participants with the highest LDL-C (≥139 mg/dL), the OR was 2.2 (95% CI 0.9–5.1) for participants with LDL-C of 115–138, 3.5 (95% CI 1.6–8.1) for LDL-C of 93–114, and 2.6 (95% CI 1.1 – 5.9) for LDL-C ≤ 92. Interestingly, use of cholesterol lowering drugs or just statins was related to lower PD prevalence. Our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence; either of which findings warrant further investigations.</p>
</abstract>
<kwd-group><kwd>Parkinson’s disease</kwd>
<kwd>LDL cholesterol</kwd>
<kwd>apolipoprotein E</kwd>
<kwd>statin</kwd>
<kwd>case control study</kwd>
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