MovDisordV3, Main, Merge, bibRecord, 003948

Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study

Identifieur interne : 003948 ( Main/Merge ); précédent : 003947; suivant : 003949

Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study

Auteurs : Blanca Ramirez-Ruiz [Espagne] ; Maria-José Marti [Espagne] ; Eduardo Tolosa [Espagne] ; Carlos Falcon [Espagne] ; Nuria Bargallo [Espagne] ; Francesc Valldeoriola [Espagne] ; Carme Junque [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:09-0058923

Descripteurs français

Pascal (Inist)
- Hallucination visuelle, Maladie de Parkinson, Pathologie du système nerveux, Encéphale, Homme, Imagerie fonctionnelle, Imagerie RMN, Attention, Face, Cortex préfrontal.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Attention, Encephalon, Face, Functional imaging, Human, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease, Prefrontal cortex, Visual hallucination.

Abstract

Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli.

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Pascal:09-0058923

Le document en format XML

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<term>Nuclear magnetic resonance imaging</term>
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<term>Visual hallucination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Hallucination visuelle</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Encéphale</term>
<term>Homme</term>
<term>Imagerie fonctionnelle</term>
<term>Imagerie RMN</term>
<term>Attention</term>
<term>Face</term>
<term>Cortex préfrontal</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name>
</region>
<name sortKey="Bargallo, Nuria" sort="Bargallo, Nuria" uniqKey="Bargallo N" first="Nuria" last="Bargallo">Nuria Bargallo</name>
<name sortKey="Falcon, Carlos" sort="Falcon, Carlos" uniqKey="Falcon C" first="Carlos" last="Falcon">Carlos Falcon</name>
<name sortKey="Falcon, Carlos" sort="Falcon, Carlos" uniqKey="Falcon C" first="Carlos" last="Falcon">Carlos Falcon</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name>
<name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria-José" last="Marti">Maria-José Marti</name>
<name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria-José" last="Marti">Maria-José Marti</name>
<name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria-José" last="Marti">Maria-José Marti</name>
<name sortKey="Ramirez Ruiz, Blanca" sort="Ramirez Ruiz, Blanca" uniqKey="Ramirez Ruiz B" first="Blanca" last="Ramirez-Ruiz">Blanca Ramirez-Ruiz</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
<name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study

Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study

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