Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study
Identifieur interne : 001340 ( PascalFrancis/Checkpoint ); précédent : 001339; suivant : 001341Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study
Auteurs : Blanca Ramirez-Ruiz [Espagne] ; Maria-José Marti [Espagne] ; Eduardo Tolosa [Espagne] ; Carlos Falcon [Espagne] ; Nuria Bargallo [Espagne] ; Francesc Valldeoriola [Espagne] ; Carme Junque [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
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- topic : Homme.
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Abstract
Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli.
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Pascal:09-0058923Le document en format XML
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<front><div type="abstract" xml:lang="en">Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli.</div>
</front>
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<fA03 i2="1"><s0>Mov. disord.</s0>
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<fA06><s2>16</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Brain Response to Complex Visual Stimuli in Parkinson's Patients with Hallucinations : A Functional Magnetic Resonance Imaging Study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>RAMIREZ-RUIZ (Blanca)</s1>
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<fA11 i1="07" i2="1"><s1>JUNQUE (Carme)</s1>
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<fA14 i1="01"><s1>Department of Psychiatry and Clinical Psychohiology, University of Barcelona</s1>
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<fA14 i1="02"><s1>Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)</s1>
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<fA14 i1="03"><s1>Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clinic de Neurociències, Hospital Clinic de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<fA14 i1="04"><s1>Centro de investigacion en red sobre enfermedades neurodegenerativas (CIBERNED)</s1>
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<fA14 i1="06"><s1>Radiology Department, Centre de Diagnòstic per la Imatge (CDI), Hospital Clinic de Barcelona</s1>
<s2>Barcelona</s2>
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<sZ>5 aut.</sZ>
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<fA20><s1>2335-2343</s1>
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<fA21><s1>2008</s1>
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<fC01 i1="01" l="ENG"><s0>Visual hallucinations (VH) in Parkinson's disease (PD) have been associated with gray matter reductions in visual associative areas and with abnormal patterns of brain activation in posterior and frontal regions. However, all previous fMRI studies have used simple visual stimuli. The objective of our study was, therefore, to compare the pattern of brain activation during a one-back face detection task. We examined 10 PD patients with VH, 10 PD patients without VH, and 10 controls matched for age and education. The fMRI task consisted in three blocks of 21-face stimuli (activation condition) and three blocks of 21-colored mosaics (control condition). Subjects were asked to press a key when two identical stimuli were presented consecutively. During the face condition, compared with patients without VH, hallucinating PD patients showed significant reductions in the activation of several right prefrontal areas, such as the inferior (BA 10,47), superior (BA 6/8), middle frontal (BA 8), and anterior cingulate gyrus (BA 31/32). In the control condition, we found a hyperactivation in the hallucinating PD sample compared with the nonVH patients in the right inferior frontal gyrus. A dysfunction of the frontal areas associated with the control of attention could predispose to VH through an abnormal processing of relevant and irrelevant visual stimuli.</s0>
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<s5>01</s5>
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