Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease
Identifieur interne : 003634 ( Main/Merge ); précédent : 003633; suivant : 003635Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease
Auteurs : Pablo Martinez-Martin [Espagne] ; Eduardo Tolosa [Espagne] ; Basilio Hernandez [Espagne] ; Xavier Badia [Espagne]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.
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Pascal:08-0251872Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease</title>
<author><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED)</s1>
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<author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
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<term>Parkinson disease</term>
<term>Questionnaire</term>
<term>Validation</term>
<term>Validity</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Validation</term>
<term>Questionnaire</term>
<term>Diagnostic</term>
<term>Homme</term>
<term>Dépistage</term>
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<front><div type="abstract" xml:lang="en">: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.</div>
</front>
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<li>Communauté de Madrid</li>
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<tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name>
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<name sortKey="Badia, Xavier" sort="Badia, Xavier" uniqKey="Badia X" first="Xavier" last="Badia">Xavier Badia</name>
<name sortKey="Hernandez, Basilio" sort="Hernandez, Basilio" uniqKey="Hernandez B" first="Basilio" last="Hernandez">Basilio Hernandez</name>
<name sortKey="Martinez Martin, Pablo" sort="Martinez Martin, Pablo" uniqKey="Martinez Martin P" first="Pablo" last="Martinez-Martin">Pablo Martinez-Martin</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
<name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name>
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