Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease
Identifieur interne : 001261 ( PascalFrancis/Corpus ); précédent : 001260; suivant : 001262Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease
Auteurs : Pablo Martinez-Martin ; Eduardo Tolosa ; Basilio Hernandez ; Xavier BadiaSource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.
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Format Inist (serveur)
NO : | PASCAL 08-0251872 INIST |
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ET : | Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease |
AU : | MARTINEZ-MARTIN (Pablo); TOLOSA (Eduardo); HERNANDEZ (Basilio); BADIA (Xavier) |
AF : | Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III, Institute of Health/Madrid/Espagne (1 aut.); Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED)/Madrid/Espagne (1 aut.); Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut, Clinic de Neurociències, Hospital Clinic de Barcelona, Universitat de Barcelona, IDIBAPS/Barcelona/Espagne (2 aut.); Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED)/Barcelona/Espagne (2 aut.); Medical Department, Novartis Farmaceutica, SA/Barcelona/Espagne (3 aut.); IMS Health/Barcelona/Espagne (4 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 6; Pp. 830-836; Bibl. 20 ref. |
LA : | Anglais |
EA : | : The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Validation; Questionnaire; Diagnostic; Homme; Dépistage; Validité |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Validation; Questionnaire; Diagnosis; Human; Medical screening; Validity |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Validación; Cuestionario; Diagnóstico; Hombre; Descubrimiento; Validez |
LO : | INIST-20953.354000195888140090 |
ID : | 08-0251872 |
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Pascal:08-0251872Le document en format XML
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<front><div type="abstract" xml:lang="en">: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.</div>
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<ET>Validation of the "QUICK" Questionnaire : A Tool for Diagnosis of "Wearing-Off" in Patients with Parkinson's Disease</ET>
<AU>MARTINEZ-MARTIN (Pablo); TOLOSA (Eduardo); HERNANDEZ (Basilio); BADIA (Xavier)</AU>
<AF>Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III, Institute of Health/Madrid/Espagne (1 aut.); Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED)/Madrid/Espagne (1 aut.); Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut, Clinic de Neurociències, Hospital Clinic de Barcelona, Universitat de Barcelona, IDIBAPS/Barcelona/Espagne (2 aut.); Centro de Investigación Biomédica en Red sobre Enfermedades, Neurodegenerativas (CIBERNED)/Barcelona/Espagne (2 aut.); Medical Department, Novartis Farmaceutica, SA/Barcelona/Espagne (3 aut.); IMS Health/Barcelona/Espagne (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 6; Pp. 830-836; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>: The main objective of the present study was to test the validity of a 19-items instrument (QUICK Questionnaire, QQ) as a tool for screening of WO. Two hundred twenty-two patients (36.0% without WO; 64.0% with mild or moderate/ severe WO) were included. Diagnosis of WO by the participant neurologist was considered the "gold standard." The complete Unified Parkinson's Disease Rating Scale battery, the Cumulative Illness Rating Scale-Geriatrics, and a form about WO presence and severity were completed by the neurologist. Patients independently completed the QQ just before the clinical assessment. As a whole, patients with WO were more disabled than patients without and patients with moderate/severe WO were in worse condition than patients with mild WO. The number of QQ symptoms declared to improve usually after the following dose of medication was 1.0 ± 1.8 in the group without WO, but 6.0 ± 3.8 in patients with WO (P < 0.001). A two QQ positive symptoms cut-off showed the following attributes: sensitivity, 88%; specificity, 80%; positive predictive value, 88.7%; negative predictive value, 79%; diagnostic accuracy, 85%; positive and negative likelihood ratios 4.4 and 0.15, respectively. The area under the ROC curve resulted 0.90 (CI95%: 0.86-0.94%). In summary, the QQ proved to be a valid screening tool to identify WO in PD patients. To our knowledge, the QQ is the only validated tool for diagnosis of WO.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Validation; Questionnaire; Diagnostic; Homme; Dépistage; Validité</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Validation; Questionnaire; Diagnosis; Human; Medical screening; Validity</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Validación; Cuestionario; Diagnóstico; Hombre; Descubrimiento; Validez</SD>
<LO>INIST-20953.354000195888140090</LO>
<ID>08-0251872</ID>
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