MovDisordV3, Main, Merge, bibRecord, 002E97

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Identifieur interne : 002E97 ( Main/Merge ); précédent : 002E96; suivant : 002E98

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Auteurs : Mélissa Tir [France] ; Christine Delmaire [France] ; Vianney Le Thuc [France] ; Alain Duhamel [France] ; Alain Destée [France] ; Jean-Pierre Pruvo [France] ; Luc Defebvre [France]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0223226

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Maladie de Parkinson, Pathologie du système nerveux, Trouble fonctionnel, Encéphale, Imagerie RMN, Cortex moteur, Imagerie de diffusion.

English descriptors

KwdEn :
- Diffusion imaging, Dysfunction, Encephalon, Motor cortex, Multiple system atrophy, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease.

Abstract

The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000E90
to stream PascalFrancis, to step Curation: 001E29
to stream PascalFrancis, to step Checkpoint: 000E00

Links to Exploration step

Pascal:09-0223226

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis</title>
<author><name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Mignot Versailles Hospital</s1>
<s2>Versaiks</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Versaiks</wicri:noRegion>
<wicri:noRegion>Mignot Versailles Hospital</wicri:noRegion>
<wicri:noRegion>Versaiks</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Thuc, Vianney" sort="Le Thuc, Vianney" uniqKey="Le Thuc V" first="Vianney" last="Le Thuc">Vianney Le Thuc</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Pruvo, Jean Pierre" sort="Pruvo, Jean Pierre" uniqKey="Pruvo J" first="Jean-Pierre" last="Pruvo">Jean-Pierre Pruvo</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0223226</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0223226 INIST</idno>
<idno type="RBID">Pascal:09-0223226</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000E90</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001E29</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E00</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Tir M:motor:related:circuit</idno>
<idno type="wicri:Area/Main/Merge">002E97</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis</title>
<author><name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Mignot Versailles Hospital</s1>
<s2>Versaiks</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Versaiks</wicri:noRegion>
<wicri:noRegion>Mignot Versailles Hospital</wicri:noRegion>
<wicri:noRegion>Versaiks</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Le Thuc, Vianney" sort="Le Thuc, Vianney" uniqKey="Le Thuc V" first="Vianney" last="Le Thuc">Vianney Le Thuc</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Pruvo, Jean Pierre" sort="Pruvo, Jean Pierre" uniqKey="Pruvo J" first="Jean-Pierre" last="Pruvo">Jean-Pierre Pruvo</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diffusion imaging</term>
<term>Dysfunction</term>
<term>Encephalon</term>
<term>Motor cortex</term>
<term>Multiple system atrophy</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Trouble fonctionnel</term>
<term>Encéphale</term>
<term>Imagerie RMN</term>
<term>Cortex moteur</term>
<term>Imagerie de diffusion</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Nord-Pas-de-Calais</li>
</region>
<settlement><li>Lille</li>
</settlement>
<orgName><li>Université Lille 2</li>
<li>Université Lille Nord de France</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name>
</noRegion>
<name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name>
<name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name>
<name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name>
<name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
<name sortKey="Le Thuc, Vianney" sort="Le Thuc, Vianney" uniqKey="Le Thuc V" first="Vianney" last="Le Thuc">Vianney Le Thuc</name>
<name sortKey="Pruvo, Jean Pierre" sort="Pruvo, Jean Pierre" uniqKey="Pruvo J" first="Jean-Pierre" last="Pruvo">Jean-Pierre Pruvo</name>
<name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E97 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 002E97 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:09-0223226
   |texte=   Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri