MovDisordV3, PascalFrancis, Corpus, bibRecord, 000E90

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Identifieur interne : 000E90 ( PascalFrancis/Corpus ); précédent : 000E89; suivant : 000E91

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Auteurs : Mélissa Tir ; Christine Delmaire ; Vianney Le Thuc ; Alain Duhamel ; Alain Destee ; Jean-Pierre Pruvo ; Luc Defebvre

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0223226

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Maladie de Parkinson, Pathologie du système nerveux, Trouble fonctionnel, Encéphale, Imagerie RMN, Cortex moteur, Imagerie de diffusion.

English descriptors

KwdEn :
- Diffusion imaging, Dysfunction, Encephalon, Motor cortex, Multiple system atrophy, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease.

Abstract

The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.
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C03	`02`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 02`
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C03	`04`	`X`	`FRE`	`@0 Trouble fonctionnel @5 09`
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C03	`04`	`X`	`SPA`	`@0 Trastorno funcional @5 09`
C03	`05`	`X`	`FRE`	`@0 Encéphale @5 10`
C03	`05`	`X`	`ENG`	`@0 Encephalon @5 10`
C03	`05`	`X`	`SPA`	`@0 Encéfalo @5 10`
C03	`06`	`X`	`FRE`	`@0 Imagerie RMN @5 11`
C03	`06`	`X`	`ENG`	`@0 Nuclear magnetic resonance imaging @5 11`
C03	`06`	`X`	`SPA`	`@0 Imaginería RMN @5 11`
C03	`07`	`X`	`FRE`	`@0 Cortex moteur @5 12`
C03	`07`	`X`	`ENG`	`@0 Motor cortex @5 12`
C03	`07`	`X`	`SPA`	`@0 Corteza motora @5 12`
C03	`08`	`X`	`FRE`	`@0 Imagerie de diffusion @4 CD @5 96`
C03	`08`	`X`	`ENG`	`@0 Diffusion imaging @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Système nerveux central @5 37`
C07	`01`	`X`	`ENG`	`@0 Central nervous system @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso central @5 37`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 39`
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C07	`04`	`X`	`FRE`	`@0 Maladie dégénérative @5 40`
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C07	`04`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
C07	`06`	`X`	`FRE`	`@0 Voie motrice @5 43`
C07	`06`	`X`	`ENG`	`@0 Motor pathway @5 43`
C07	`06`	`X`	`SPA`	`@0 Vía motora @5 43`
N21				`@1 166`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0223226 INIST
ET :	Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis
AU :	TIR (Mélissa); DELMAIRE (Christine); LE THUC (Vianney); DUHAMEL (Alain); DESTEE (Alain); PRUVO (Jean-Pierre); DEFEBVRE (Luc)
AF :	Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre/Lille/France (1 aut., 5 aut., 7 aut.); Department of Neurology, Mignot Versailles Hospital/Versaiks/France (1 aut.); Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre/Lille/France (2 aut., 3 aut., 6 aut.); Department of Biostatistics, Salengro Hospital, Lille University Medical Centre/Lille/France (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 6; Pp. 863-870; Bibl. 40 ref.
LA :	Anglais
EA :	The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.
CC :	002B17; 002B24A06
FD :	Atrophie multisystématisée; Maladie de Parkinson; Pathologie du système nerveux; Trouble fonctionnel; Encéphale; Imagerie RMN; Cortex moteur; Imagerie de diffusion
FG :	Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Voie motrice
ED :	Multiple system atrophy; Parkinson disease; Nervous system diseases; Dysfunction; Encephalon; Nuclear magnetic resonance imaging; Motor cortex; Diffusion imaging
EG :	Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Motor pathway
SD :	Atrofia multisistematizada; Parkinson enfermedad; Sistema nervioso patología; Trastorno funcional; Encéfalo; Imaginería RMN; Corteza motora
LO :	INIST-20953.354000186181820100
ID :	09-0223226

Links to Exploration step

Pascal:09-0223226

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.</div>
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<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="04"><s1>Department of Biostatistics, Salengro Hospital, Lille University Medical Centre</s1>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
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<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
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<fA60><s1>P</s1>
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<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Trouble fonctionnel</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Dysfunction</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Trastorno funcional</s0>
<s5>09</s5>
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<s5>10</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>10</s5>
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<fC03 i1="07" i2="X" l="ENG"><s0>Motor cortex</s0>
<s5>12</s5>
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<fC03 i1="07" i2="X" l="SPA"><s0>Corteza motora</s0>
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</fC03>
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<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
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<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Voie motrice</s0>
<s5>43</s5>
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<fC07 i1="06" i2="X" l="ENG"><s0>Motor pathway</s0>
<s5>43</s5>
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<fC07 i1="06" i2="X" l="SPA"><s0>Vía motora</s0>
<s5>43</s5>
</fC07>
<fN21><s1>166</s1>
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<server><NO>PASCAL 09-0223226 INIST</NO>
<ET>Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis</ET>
<AU>TIR (Mélissa); DELMAIRE (Christine); LE THUC (Vianney); DUHAMEL (Alain); DESTEE (Alain); PRUVO (Jean-Pierre); DEFEBVRE (Luc)</AU>
<AF>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre/Lille/France (1 aut., 5 aut., 7 aut.); Department of Neurology, Mignot Versailles Hospital/Versaiks/France (1 aut.); Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre/Lille/France (2 aut., 3 aut., 6 aut.); Department of Biostatistics, Salengro Hospital, Lille University Medical Centre/Lille/France (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 6; Pp. 863-870; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.</EA>
<CC>002B17; 002B24A06</CC>
<FD>Atrophie multisystématisée; Maladie de Parkinson; Pathologie du   système nerveux; Trouble fonctionnel; Encéphale; Imagerie RMN; Cortex moteur; Imagerie de diffusion</FD>
<FG>Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Voie motrice</FG>
<ED>Multiple system atrophy; Parkinson disease; Nervous system diseases; Dysfunction; Encephalon; Nuclear magnetic resonance imaging; Motor cortex; Diffusion imaging</ED>
<EG>Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Motor pathway</EG>
<SD>Atrofia multisistematizada; Parkinson enfermedad; Sistema nervioso patología; Trastorno funcional; Encéfalo; Imaginería RMN; Corteza motora</SD>
<LO>INIST-20953.354000186181820100</LO>
<ID>09-0223226</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis

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