Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis
Identifieur interne : 000E00 ( PascalFrancis/Checkpoint ); précédent : 000D99; suivant : 000E01Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis
Auteurs : Mélissa Tir [France] ; Christine Delmaire [France] ; Vianney Le Thuc [France] ; Alain Duhamel [France] ; Alain Destée [France] ; Jean-Pierre Pruvo [France] ; Luc Defebvre [France]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.
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sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Le Thuc, Vianney" sort="Le Thuc, Vianney" uniqKey="Le Thuc V" first="Vianney" last="Le Thuc">Vianney Le Thuc</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" 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aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0223226</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0223226 INIST</idno><idno type="RBID">Pascal:09-0223226</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E90</idno><idno type="wicri:Area/PascalFrancis/Curation">001E29</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis</title><author><name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Mignot Versailles Hospital</s1><s2>Versaiks</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Versaiks</wicri:noRegion><wicri:noRegion>Mignot Versailles Hospital</wicri:noRegion><wicri:noRegion>Versaiks</wicri:noRegion></affiliation></author><author><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Le Thuc, Vianney" sort="Le Thuc, Vianney" uniqKey="Le Thuc V" first="Vianney" last="Le Thuc">Vianney Le Thuc</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Pruvo, Jean Pierre" sort="Pruvo, Jean Pierre" uniqKey="Pruvo J" first="Jean-Pierre" last="Pruvo">Jean-Pierre Pruvo</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diffusion imaging</term><term>Dysfunction</term><term>Encephalon</term><term>Motor cortex</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Trouble fonctionnel</term><term>Encéphale</term><term>Imagerie RMN</term><term>Cortex moteur</term><term>Imagerie de diffusion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>6</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Motor-Related Circuit Dysfunction in MSA-P : Usefulness of Combined Whole-Brain Imaging Analysis</s1></fA08><fA11 i1="01" i2="1"><s1>TIR (Mélissa)</s1></fA11><fA11 i1="02" i2="1"><s1>DELMAIRE (Christine)</s1></fA11><fA11 i1="03" i2="1"><s1>LE THUC (Vianney)</s1></fA11><fA11 i1="04" i2="1"><s1>DUHAMEL (Alain)</s1></fA11><fA11 i1="05" i2="1"><s1>DESTEE (Alain)</s1></fA11><fA11 i1="06" i2="1"><s1>PRUVO (Jean-Pierre)</s1></fA11><fA11 i1="07" i2="1"><s1>DEFEBVRE (Luc)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurology, Mignot Versailles Hospital</s1><s2>Versaiks</s2><s3>FRA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neuroradiology, EA2683, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Biostatistics, Salengro Hospital, Lille University Medical Centre</s1><s2>Lille</s2><s3>FRA</s3><sZ>4 aut.</sZ></fA14><fA20><s1>863-870</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000186181820100</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>40 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>09-0223226</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The aim of this study was to evaluate in vivo changes in the brain's macro- and microstructure (notably in the motor system) in the parkinsonian variant of multiple system atrophy (MSA-P) and in Parkinson's disease (PD) and to characterize the cerebral anatomical differences between the two conditions. We used a combination of voxel-based morphometry (VBM) and whole-brain, voxel-based diffusion tensor imaging analysis (VB-DTI). Forty-seven right-handed subjects (14 MSA-P patients, 19 PD patients, and 14 controls) were evaluated using VBM and VB-DTI in an analysis of covariance (ANCOVA) with a significance threshold set to P < 0.005. In MSA-P patients, VBM analysis revealed a lower density of grey matter (GM) in a motor-related circuit (especially in the left primary motor cortex, PMC), relative to PD patients, and in the left supplementary motor area (SMA), relative to controls). Diffusion tensor imaging analysis revealed lower fractional anisotropy (FA) values in the left PMC and the right cerebellum in MSA-P patients, compared with controls. Using a volumetric diffusion technique, our study revealed selective tissue degeneration in motor circuits, regardless of the volume loss detected in VBM and in agreement with pathology reports and clinical motor characteristics. Our findings suggest that MSA-P is characterized by both macro- and microstructural changes in the sensorimotor circuit.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B24A06</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Atrophie multisystématisée</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Multiple system atrophy</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Atrofia multisistematizada</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Trouble fonctionnel</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dysfunction</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Trastorno funcional</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Encéphale</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Encephalon</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Encéfalo</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Cortex moteur</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Motor cortex</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Corteza motora</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Imagerie de diffusion</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Diffusion imaging</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Voie motrice</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Motor pathway</s0><s5>43</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Vía motora</s0><s5>43</s5></fC07><fN21><s1>166</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name></noRegion><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><name sortKey="Delmaire, Christine" sort="Delmaire, Christine" uniqKey="Delmaire C" first="Christine" last="Delmaire">Christine Delmaire</name><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><name sortKey="Le Thuc, Vianney" sort="Le Thuc, Vianney" uniqKey="Le Thuc V" first="Vianney" last="Le Thuc">Vianney Le Thuc</name><name sortKey="Pruvo, Jean Pierre" sort="Pruvo, Jean Pierre" uniqKey="Pruvo J" first="Jean-Pierre" last="Pruvo">Jean-Pierre Pruvo</name><name sortKey="Tir, Melissa" sort="Tir, Melissa" uniqKey="Tir M" first="Mélissa" last="Tir">Mélissa Tir</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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