Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
Identifieur interne : 002A87 ( Main/Merge ); précédent : 002A86; suivant : 002A88Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
Auteurs : Jens Volkmann [Allemagne] ; Alberto Albanese [Italie] ; Jaime Kulisevsky [Espagne] ; Aana-Lena Tornqvist [Suède] ; Jean-Luc Houeto [France] ; Bernard Pidoux [France] ; Anne-Marie Bonnet [France] ; Alexandre Mendes [France] ; Alim-Louis Benabid [France] ; Valerie Fraix [France] ; Nadege Van Blercom [France] ; Jing Xie [France] ; José Obeso [Espagne] ; Maria Cruz Rodriguez-Oroz [Espagne] ; Jurge Guridi [Espagne] ; Alfons Schnitzler [Allemagne] ; Lars Timmermann [Allemagne] ; Alexandre A. Gironell [Espagne] ; Juan Molet [Espagne] ; Benta Pascual-Sedano [Espagne] ; Stig Rehncrona [Suède] ; Elena Moro [Canada] ; Anthony C. Lang [Canada] ; Andres M. Lozano [Canada] ; Anna Rita Bentivoglio [Italie] ; Massimo Scerrati [Italie] ; Maria Fiorella Contarino [Pays-Bas] ; Luigi Romito [Italie] ; Marc Janssens [Pays-Bas] ; Yves Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Deep Brain Stimulation, Emotions (physiology), Female, Globus Pallidus (physiology), Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson's disease/parkinsonism, Quality of Life (psychology), Questionnaires, Sickness Impact Profile, Statistics, Nonparametric, Subthalamic Nucleus (physiology), Time Factors, deep brain stimulation, globus pallidus, quality of life, subthalamic nucleus.
- MESH :
- physiology : Emotions, Globus Pallidus, Subthalamic Nucleus.
- psychology : Parkinson Disease, Quality of Life.
- therapy : Parkinson Disease.
- Activities of Daily Living, Aged, Deep Brain Stimulation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Questionnaires, Sickness Impact Profile, Statistics, Nonparametric, Time Factors.
Abstract
We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22496
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Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Universität zu Köln, Köln</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName><orgName type="university">Université de Cologne</orgName></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academisch Medisch Centrum, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Bakken Research Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1154">1154</biblScope><biblScope unit="page" to="1161">1161</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><idno type="DOI">10.1002/mds.22496</idno><idno type="ArticleID">MDS22496</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Emotions (physiology)</term><term>Female</term><term>Globus Pallidus (physiology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson's disease/parkinsonism</term><term>Quality of Life (psychology)</term><term>Questionnaires</term><term>Sickness Impact Profile</term><term>Statistics, Nonparametric</term><term>Subthalamic Nucleus (physiology)</term><term>Time Factors</term><term>deep brain stimulation</term><term>globus pallidus</term><term>quality of life</term><term>subthalamic nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Emotions</term><term>Globus Pallidus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Questionnaires</term><term>Sickness Impact Profile</term><term>Statistics, Nonparametric</term><term>Time Factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.22496"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></author><author><name sortKey="Tornqvist, Aana Ena" sort="Tornqvist, Aana Ena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name></author><author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22496</idno><idno type="url">https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000412</idno><idno type="wicri:Area/Istex/Curation">000412</idno><idno type="wicri:Area/Istex/Checkpoint">000E28</idno><idno type="wicri:doubleKey">0885-3185:2009:Volkmann J:long:term:effects</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Tornqvist, Aana Ena" sort="Tornqvist, Aana Ena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Universität zu Köln, Köln</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName><orgName type="university">Université de Cologne</orgName></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Catholic University, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academisch Medisch Centrum, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Bakken Research Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1154">1154</biblScope><biblScope unit="page" to="1161">1161</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><idno type="DOI">10.1002/mds.22496</idno><idno type="ArticleID">MDS22496</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease/parkinsonism</term><term>deep brain stimulation</term><term>globus pallidus</term><term>quality of life</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease.</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><nlm:affiliation>Neurologische Klinik der Christian-Albrechts-Universität, Kiel, Germany. j.volkmann@neurologie.uni-kiel.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Christian-Albrechts-Universität, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></author><author><name sortKey="Tornqvist, Aana Lena" sort="Tornqvist, Aana Lena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name></author><author><name sortKey="Rodriguez Oroz, Maria Cruz" sort="Rodriguez Oroz, Maria Cruz" uniqKey="Rodriguez Oroz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A" last="Gironell">Alexandre A. Gironell</name></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name></author><author><name sortKey="Pascual Sedano, Benta" sort="Pascual Sedano, Benta" uniqKey="Pascual Sedano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C" last="Lang">Anthony C. Lang</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22496</idno><idno type="RBID">pubmed:19412954</idno><idno type="pmid">19412954</idno><idno type="wicri:Area/PubMed/Corpus">001D26</idno><idno type="wicri:Area/PubMed/Curation">001D26</idno><idno type="wicri:Area/PubMed/Checkpoint">001D34</idno><idno type="wicri:Area/Ncbi/Merge">002651</idno><idno type="wicri:Area/Ncbi/Curation">002651</idno><idno type="wicri:Area/Ncbi/Checkpoint">002651</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease.</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="3"><nlm:affiliation>Neurologische Klinik der Christian-Albrechts-Universität, Kiel, Germany. j.volkmann@neurologie.uni-kiel.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Christian-Albrechts-Universität, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name></author><author><name sortKey="Tornqvist, Aana Lena" sort="Tornqvist, Aana Lena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name></author><author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name></author><author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name></author><author><name sortKey="Rodriguez Oroz, Maria Cruz" sort="Rodriguez Oroz, Maria Cruz" uniqKey="Rodriguez Oroz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A" last="Gironell">Alexandre A. Gironell</name></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name></author><author><name sortKey="Pascual Sedano, Benta" sort="Pascual Sedano, Benta" uniqKey="Pascual Sedano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C" last="Lang">Anthony C. Lang</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Emotions (physiology)</term><term>Female</term><term>Globus Pallidus (physiology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Quality of Life (psychology)</term><term>Questionnaires</term><term>Sickness Impact Profile</term><term>Statistics, Nonparametric</term><term>Subthalamic Nucleus (physiology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Emotions</term><term>Globus Pallidus</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Questionnaires</term><term>Sickness Impact Profile</term><term>Statistics, Nonparametric</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi-DBS and n = 45/49 patients with STN-DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off-period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN-DBS and M, SI after GPi-DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN-DBS and GPi-DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health-related wellbeing over time.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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