Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
Identifieur interne : 000412 ( Istex/Corpus ); précédent : 000411; suivant : 000413Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
Auteurs : Jens Volkmann ; Alberto Albanese ; Jaime Kulisevsky ; Aana-Lena Tornqvist ; Jean-Luc Houeto ; Bernard Pidoux ; Anne-Marie Bonnet ; Alexandre Mendes ; Alim-Louis Benabid ; Valerie Fraix ; Nadege Van Blercom ; Jing Xie ; José Obeso ; Maria Cruz Rodriguez-Oroz ; Jurge Guridi ; Alfons Schnitzler ; Lars Timmermann ; Alexandre A. Gironell ; Juan Molet ; Benta Pascual-Sedano ; Stig Rehncrona ; Elena Moro ; Anthony C. Lang ; Andres M. Lozano ; Anna Rita Bentivoglio ; Massimo Scerrati ; Maria Fiorella Contarino ; Luigi Romito ; Marc Janssens ; Yves AgidSource :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
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Abstract
We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22496
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation><mods:affiliation>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Tornqvist, Aana Ena" sort="Tornqvist, Aana Ena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author><author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation><mods:affiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation><mods:affiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><mods:affiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><mods:affiliation>Department of Neuroscience, Catholic University, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name><affiliation><mods:affiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22496</idno><idno type="url">https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation><mods:affiliation>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Tornqvist, Aana Ena" sort="Tornqvist, Aana Ena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author><author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation><mods:affiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation><mods:affiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</mods:affiliation></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><mods:affiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><mods:affiliation>Department of Neuroscience, Catholic University, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name><affiliation><mods:affiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1154">1154</biblScope><biblScope unit="page" to="1161">1161</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><idno type="DOI">10.1002/mds.22496</idno><idno type="ArticleID">MDS22496</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease/parkinsonism</term><term>deep brain stimulation</term><term>globus pallidus</term><term>quality of life</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jens Volkmann MD</name><affiliations><json:string>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Alberto Albanese MD</name><affiliations><json:string>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</json:string></affiliations></json:item><json:item><name>Jaime Kulisevsky MD</name><affiliations><json:string>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Aana‐Lena Tornqvist PhD</name><affiliations><json:string>Department of Neurosurgery, University Hospital, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Jean‐Luc Houeto MD</name><affiliations><json:string>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</json:string></affiliations></json:item><json:item><name>Bernard Pidoux MD</name><affiliations><json:string>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</json:string></affiliations></json:item><json:item><name>Anne‐Marie Bonnet MD</name><affiliations><json:string>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</json:string></affiliations></json:item><json:item><name>Alexandre Mendes MD</name><affiliations><json:string>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Alim‐Louis Benabid MD</name><affiliations><json:string>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Valerie Fraix PhD</name><affiliations><json:string>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Nadege Van Blercom PhD</name><affiliations><json:string>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>Jing Xie MD</name><affiliations><json:string>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</json:string></affiliations></json:item><json:item><name>José Obeso MD</name><affiliations><json:string>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</json:string></affiliations></json:item><json:item><name>Maria Cruz Rodriguez‐Oroz MD</name><affiliations><json:string>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</json:string></affiliations></json:item><json:item><name>Jurge Guridi MD</name><affiliations><json:string>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</json:string></affiliations></json:item><json:item><name>Alfons Schnitzler MD</name><affiliations><json:string>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</json:string></affiliations></json:item><json:item><name>Lars Timmermann MD</name><affiliations><json:string>Neurologische Klinik, Universität zu Köln, Köln, Germany</json:string></affiliations></json:item><json:item><name>Alexandre A. Gironell MD</name><affiliations><json:string>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Juan Molet MD</name><affiliations><json:string>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Benta Pascual‐Sedano MD</name><affiliations><json:string>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>Stig Rehncrona MD</name><affiliations><json:string>Department of Neurosurgery, University Hospital, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Elena Moro MD</name><affiliations><json:string>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Anthony C. Lang MD</name><affiliations><json:string>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Andres M. Lozano MD</name><affiliations><json:string>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Anna Rita Bentivoglio MD</name><affiliations><json:string>Department of Neuroscience, Catholic University, Rome, Italy</json:string></affiliations></json:item><json:item><name>Massimo Scerrati MD</name><affiliations><json:string>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</json:string></affiliations></json:item><json:item><name>Maria Fiorella Contarino MD</name><affiliations><json:string>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Luigi Romito MD</name><affiliations><json:string>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</json:string></affiliations></json:item><json:item><name>Marc Janssens PhD</name><affiliations><json:string>Bakken Research Center, Maastricht, The Netherlands</json:string></affiliations></json:item><json:item><name>Yves Agid MD</name><affiliations><json:string>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>quality of life</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease/parkinsonism</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>globus pallidus</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>7.616</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1760</abstractCharCount><pdfWordCount>4616</pdfWordCount><pdfCharCount>31641</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>262</abstractWordCount></qualityIndicators><title>Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>24</volume><pages><total>8</total><last>1161</last><first>1154</first></pages><issn><json:string>0885-3185</json:string></issn><issue>8</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22496</json:string></doi><id>FDA0A72C22C4885F675F0E514181735A1BDAAE66</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: M.J. is a full‐time employee of Medtronic. All other authors have occasionally received honoraria from Medtronic for lecturing at conferences or consulting work. The authors report no financial conflicts of interest. The statistical analysis were conducted by M.J. (Bakken Research Center, NL) and the members of the writing committee (J.V., A.A., J.K., A.‐L.T., Y.A.). The authors have confirmed with the Editor that their work complies with the Journal's Editorial policy on ghost‐writing (Movement Disorders 2005;20:1536).</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><author><persName><forename type="first">Jens</forename><surname>Volkmann</surname><roleName type="degree">MD</roleName></persName><note type="correspondence"><p>Correspondence: Department of Neurology, Christian‐Albrechts‐University, Schittenhelmstr. 10, D‐24105 Kiel, Germany</p></note><affiliation>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</affiliation></author><author><persName><forename type="first">Alberto</forename><surname>Albanese</surname><roleName type="degree">MD</roleName></persName><affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</affiliation></author><author><persName><forename type="first">Jaime</forename><surname>Kulisevsky</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Aana‐Lena</forename><surname>Tornqvist</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</affiliation></author><author><persName><forename type="first">Jean‐Luc</forename><surname>Houeto</surname><roleName type="degree">MD</roleName></persName><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation></author><author><persName><forename type="first">Bernard</forename><surname>Pidoux</surname><roleName type="degree">MD</roleName></persName><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation></author><author><persName><forename type="first">Anne‐Marie</forename><surname>Bonnet</surname><roleName type="degree">MD</roleName></persName><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation></author><author><persName><forename type="first">Alexandre</forename><surname>Mendes</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Alim‐Louis</forename><surname>Benabid</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Valerie</forename><surname>Fraix</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Nadege</forename><surname>Van Blercom</surname><roleName type="degree">PhD</roleName></persName><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">Jing</forename><surname>Xie</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation></author><author><persName><forename type="first">José</forename><surname>Obeso</surname><roleName type="degree">MD</roleName></persName><affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</affiliation></author><author><persName><forename type="first">Maria Cruz</forename><surname>Rodriguez‐Oroz</surname><roleName type="degree">MD</roleName></persName><affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</affiliation></author><author><persName><forename type="first">Jurge</forename><surname>Guridi</surname><roleName type="degree">MD</roleName></persName><affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</affiliation></author><author><persName><forename type="first">Alfons</forename><surname>Schnitzler</surname><roleName type="degree">MD</roleName></persName><affiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</affiliation></author><author><persName><forename type="first">Lars</forename><surname>Timmermann</surname><roleName type="degree">MD</roleName></persName><affiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</affiliation></author><author><persName><forename type="first">Alexandre A.</forename><surname>Gironell</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Juan</forename><surname>Molet</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Benta</forename><surname>Pascual‐Sedano</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation></author><author><persName><forename type="first">Stig</forename><surname>Rehncrona</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</affiliation></author><author><persName><forename type="first">Elena</forename><surname>Moro</surname><roleName type="degree">MD</roleName></persName><affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Anthony C.</forename><surname>Lang</surname><roleName type="degree">MD</roleName></persName><affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Andres M.</forename><surname>Lozano</surname><roleName type="degree">MD</roleName></persName><affiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Anna Rita</forename><surname>Bentivoglio</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neuroscience, Catholic University, Rome, Italy</affiliation></author><author><persName><forename type="first">Massimo</forename><surname>Scerrati</surname><roleName type="degree">MD</roleName></persName><affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</affiliation></author><author><persName><forename type="first">Maria Fiorella</forename><surname>Contarino</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</affiliation></author><author><persName><forename type="first">Luigi</forename><surname>Romito</surname><roleName type="degree">MD</roleName></persName><affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</affiliation></author><author><persName><forename type="first">Marc</forename><surname>Janssens</surname><roleName type="degree">PhD</roleName></persName><affiliation>Bakken Research Center, Maastricht, The Netherlands</affiliation></author><author><persName><forename type="first">Yves</forename><surname>Agid</surname><roleName type="degree">MD</roleName></persName><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15"></date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1154">1154</biblScope><biblScope unit="page" to="1161">1161</biblScope></imprint></monogr><idno type="istex">FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><idno type="DOI">10.1002/mds.22496</idno><idno type="ArticleID">MDS22496</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>quality of life</term></item><item><term>Parkinson's disease/parkinsonism</term></item><item><term>deep brain stimulation</term></item><item><term>subthalamic nucleus</term></item><item><term>globus pallidus</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-07-04">Received</change><change when="2009-01-22">Registration</change><change when="2009-06-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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href="file:MDS.MDS22496.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="30"></count><count type="wordTotal" number="8332"></count></countGroup><titleGroup><title type="main" xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease<link href="#fn2"></link></title><title type="short" xml:lang="en">Quality of Life in PD After DBS</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Jens</givenNames><familyName>Volkmann</familyName><degrees>MD</degrees></personName><contactDetails><email normalForm="j.volkmann@neurologie.uni-kiel.de">j.volkmann@neurologie.uni‐kiel.de</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" 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affiliationRef="#af6"><personName><givenNames>Jing</givenNames><familyName>Xie</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af7"><personName><givenNames>José</givenNames><familyName>Obeso</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Maria Cruz</givenNames><familyName>Rodriguez‐Oroz</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Jurge</givenNames><familyName>Guridi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Alfons</givenNames><familyName>Schnitzler</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Lars</givenNames><familyName>Timmermann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Alexandre A.</givenNames><familyName>Gironell</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au19" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Juan</givenNames><familyName>Molet</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au20" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Benta</givenNames><familyName>Pascual‐Sedano</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au21" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Stig</givenNames><familyName>Rehncrona</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au22" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Elena</givenNames><familyName>Moro</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au23" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Anthony C.</givenNames><familyName>Lang</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au24" creatorRole="author" affiliationRef="#af11"><personName><givenNames>Andres M.</givenNames><familyName>Lozano</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au25" creatorRole="author" affiliationRef="#af12"><personName><givenNames>Anna Rita</givenNames><familyName>Bentivoglio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au26" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Massimo</givenNames><familyName>Scerrati</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au27" creatorRole="author" affiliationRef="#af13"><personName><givenNames>Maria Fiorella</givenNames><familyName>Contarino</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au28" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Luigi</givenNames><familyName>Romito</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au29" creatorRole="author" affiliationRef="#af14"><personName><givenNames>Marc</givenNames><familyName>Janssens</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au30" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Yves</givenNames><familyName>Agid</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="ES" type="organization"><unparsedAffiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="SE" type="organization"><unparsedAffiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="ES" type="organization"><unparsedAffiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="DE" type="organization"><unparsedAffiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="DE" type="organization"><unparsedAffiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="CA" type="organization"><unparsedAffiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af12" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neuroscience, Catholic University, Rome, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af13" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="af14" countryCode="NL" type="organization"><unparsedAffiliation>Bakken Research Center, Maastricht, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">quality of life</keyword><keyword xml:id="kwd2">Parkinson's disease/parkinsonism</keyword><keyword xml:id="kwd3">deep brain stimulation</keyword><keyword xml:id="kwd4">subthalamic nucleus</keyword><keyword xml:id="kwd5">globus pallidus</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: M.J. is a full‐time employee of Medtronic. All other authors have occasionally received honoraria from Medtronic for lecturing at conferences or consulting work. The authors report no financial conflicts of interest. The statistical analysis were conducted by M.J. (Bakken Research Center, NL) and the members of the writing committee (J.V., A.A., J.K., A.‐L.T., Y.A.). The authors have confirmed with the Editor that their work complies with the Journal's Editorial policy on ghost‐writing (Movement Disorders 2005;20:1536).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 4-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Quality of Life in PD After DBS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Volkmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</affiliation><description>Correspondence: Department of Neurology, Christian‐Albrechts‐University, Schittenhelmstr. 10, D‐24105 Kiel, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Albanese</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaime</namePart><namePart type="family">Kulisevsky</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aana‐Lena</namePart><namePart type="family">Tornqvist</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Luc</namePart><namePart type="family">Houeto</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernard</namePart><namePart type="family">Pidoux</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anne‐Marie</namePart><namePart type="family">Bonnet</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandre</namePart><namePart type="family">Mendes</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alim‐Louis</namePart><namePart type="family">Benabid</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valerie</namePart><namePart type="family">Fraix</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nadege</namePart><namePart type="family">Van Blercom</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jing</namePart><namePart type="family">Xie</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">José</namePart><namePart type="family">Obeso</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria Cruz</namePart><namePart type="family">Rodriguez‐Oroz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jurge</namePart><namePart type="family">Guridi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfons</namePart><namePart type="family">Schnitzler</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lars</namePart><namePart type="family">Timmermann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandre A.</namePart><namePart type="family">Gironell</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juan</namePart><namePart type="family">Molet</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Benta</namePart><namePart type="family">Pascual‐Sedano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stig</namePart><namePart type="family">Rehncrona</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Moro</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony C.</namePart><namePart type="family">Lang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres M.</namePart><namePart type="family">Lozano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna Rita</namePart><namePart type="family">Bentivoglio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, Catholic University, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Massimo</namePart><namePart type="family">Scerrati</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria Fiorella</namePart><namePart type="family">Contarino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Romito</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Janssens</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Bakken Research Center, Maastricht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yves</namePart><namePart type="family">Agid</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-06-15</dateIssued><dateCaptured encoding="w3cdtf">2008-07-04</dateCaptured><dateValid encoding="w3cdtf">2009-01-22</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">30</extent><extent unit="words">8332</extent></physicalDescription><abstract lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: M.J. is a full‐time employee of Medtronic. All other authors have occasionally received honoraria from Medtronic for lecturing at conferences or consulting work. The authors report no financial conflicts of interest. The statistical analysis were conducted by M.J. (Bakken Research Center, NL) and the members of the writing committee (J.V., A.A., J.K., A.‐L.T., Y.A.). The authors have confirmed with the Editor that their work complies with the Journal's Editorial policy on ghost‐writing (Movement Disorders 2005;20:1536).</note><subject lang="en"><genre>Keywords</genre><topic>quality of life</topic><topic>Parkinson's disease/parkinsonism</topic><topic>deep brain stimulation</topic><topic>subthalamic nucleus</topic><topic>globus pallidus</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1154</start><end>1161</end><total>8</total></extent></part></relatedItem><identifier type="istex">FDA0A72C22C4885F675F0E514181735A1BDAAE66</identifier><identifier type="DOI">10.1002/mds.22496</identifier><identifier type="ArticleID">MDS22496</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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