Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
Identifieur interne : 000412 ( Istex/Curation ); précédent : 000411; suivant : 000413Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease
Auteurs : Jens Volkmann [Allemagne] ; Alberto Albanese [Italie] ; Jaime Kulisevsky [Espagne] ; Aana-Lena Tornqvist [Suède] ; Jean-Luc Houeto [France] ; Bernard Pidoux [France] ; Anne-Marie Bonnet [France] ; Alexandre Mendes [France] ; Alim-Louis Benabid [France] ; Valerie Fraix [France] ; Nadege Van Blercom [France] ; Jing Xie [France] ; José Obeso [Espagne] ; Maria Cruz Rodriguez-Oroz [Espagne] ; Jurge Guridi [Espagne] ; Alfons Schnitzler [Allemagne] ; Lars Timmermann [Allemagne] ; Alexandre A. Gironell [Espagne] ; Juan Molet [Espagne] ; Benta Pascual-Sedano [Espagne] ; Stig Rehncrona [Suède] ; Elena Moro [Canada] ; Anthony C. Lang [Canada] ; Andres M. Lozano [Canada] ; Anna Rita Bentivoglio [Italie] ; Massimo Scerrati [Italie] ; Maria Fiorella Contarino [Pays-Bas] ; Luigi Romito [Italie] ; Marc Janssens [Pays-Bas] ; Yves Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
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Abstract
We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22496
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Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation wicri:level="1"><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation wicri:level="1"><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation wicri:level="1"><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><mods:affiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><mods:affiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Universität zu Köln, Köln</wicri:regionArea></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><mods:affiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, Catholic University, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Catholic University, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academisch Medisch Centrum, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Bakken Research Center, Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22496</idno><idno type="url">https://api.istex.fr/document/FDA0A72C22C4885F675F0E514181735A1BDAAE66/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000412</idno><idno type="wicri:Area/Istex/Curation">000412</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long‐term effects of pallidal or subthalamic deep brain stimulation on quality of life in Parkinson's disease</title><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><mods:affiliation>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik der Christian‐Albrechts‐Universität, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Tornqvist, Aana Ena" sort="Tornqvist, Aana Ena" uniqKey="Tornqvist A" first="Aana-Lena" last="Tornqvist">Aana-Lena Tornqvist</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="3"><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name><affiliation wicri:level="3"><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Bonnet, Anne Arie" sort="Bonnet, Anne Arie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name><affiliation wicri:level="3"><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author><author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Benabid, Alim Ouis" sort="Benabid, Alim Ouis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadege" last="Van Blercom">Nadege Van Blercom</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology or Neurosurgery, University Hospital of Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="José" last="Obeso">José Obeso</name><affiliation wicri:level="1"><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Roz, Maria Cruz" sort="Rodriguez Roz, Maria Cruz" uniqKey="Rodriguez Roz M" first="Maria Cruz" last="Rodriguez-Oroz">Maria Cruz Rodriguez-Oroz</name><affiliation wicri:level="1"><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Guridi, Jurge" sort="Guridi, Jurge" uniqKey="Guridi J" first="Jurge" last="Guridi">Jurge Guridi</name><affiliation wicri:level="1"><mods:affiliation>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Deparment of Neurology and Neurosurgery, Neuroscience Division, Clinica Universitaria and Medical School, CIMA, and CIBERNED, Pamplona</wicri:regionArea></affiliation></author><author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name><affiliation wicri:level="1"><mods:affiliation>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Heinrich‐Heine‐Universität Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name><affiliation wicri:level="1"><mods:affiliation>Neurologische Klinik, Universität zu Köln, Köln, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik, Universität zu Köln, Köln</wicri:regionArea></affiliation></author><author><name sortKey="Gironell, Alexandre A" sort="Gironell, Alexandre A" uniqKey="Gironell A" first="Alexandre A." last="Gironell">Alexandre A. Gironell</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Molet, Juan" sort="Molet, Juan" uniqKey="Molet J" first="Juan" last="Molet">Juan Molet</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Pascual Edano, Benta" sort="Pascual Edano, Benta" uniqKey="Pascual Edano B" first="Benta" last="Pascual-Sedano">Benta Pascual-Sedano</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital de Sant Pau and CIBERNED, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University Hospital, Lund, Sweden</mods:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurosurgery, University Hospital, Lund</wicri:regionArea></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Lang, Anthony C" sort="Lang, Anthony C" uniqKey="Lang A" first="Anthony C." last="Lang">Anthony C. Lang</name><affiliation wicri:level="1"><mods:affiliation>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation wicri:level="1"><mods:affiliation>Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurosurgery, University of Toronto, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation wicri:level="1"><mods:affiliation>Department of Neuroscience, Catholic University, Rome, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience, Catholic University, Rome</wicri:regionArea></affiliation></author><author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Contarino, Maria Fiorella" sort="Contarino, Maria Fiorella" uniqKey="Contarino M" first="Maria Fiorella" last="Contarino">Maria Fiorella Contarino</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Academisch Medisch Centrum, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Academisch Medisch Centrum, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><mods:affiliation>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Neurologico C. Besta and Universita' Cattolica, Milan</wicri:regionArea></affiliation></author><author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name><affiliation wicri:level="1"><mods:affiliation>Bakken Research Center, Maastricht, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Bakken Research Center, Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="3"><mods:affiliation>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere, Paris</mods:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName><wicri:orgArea>Centre d'Investigation Clinique, Groupe Hospitalier Pitie'‐Salpetriere</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1154">1154</biblScope><biblScope unit="page" to="1161">1161</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">FDA0A72C22C4885F675F0E514181735A1BDAAE66</idno><idno type="DOI">10.1002/mds.22496</idno><idno type="ArticleID">MDS22496</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease/parkinsonism</term><term>deep brain stimulation</term><term>globus pallidus</term><term>quality of life</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN‐DBS) or internal pallidum (GPi‐DBS) on health‐related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a subgroup of n = 20/20 patients with GPi‐DBS and n = 45/49 patients with STN‐DBS at baseline, 6 and 36 months. The SIP provides a physical dimension and a psychosocial dimension sum score and 12 category scores: Alertness/Intellectual Behavior (AIB), Ambulation (A), Body Care and Movement (BCM), Communication (C), Eating (E), Emotional Behavior (EB), Home Management (HM), Mobility (M), Recreation and Pastimes (RP), Sleep and Rest (SR), Social Interaction (SI), and Work (W). Motor functioning was assessed by means of the Unified Parkinson's Disease Rating Scale and diaries. At 6 months significant improvements in off‐period motor symptoms and activities of daily living were paralleled by significant reductions in the total, physical, and psychosocial SIP score in both treatment groups. At 3 years, sustained improvements were observed in the physical dimension score, BCM, E, M, RP after STN‐DBS and M, SI after GPi‐DBS. All other SIP subscores approached baseline values, but were still the same or better (except C) whereas motor functioning remained stable after 36 months. STN‐DBS and GPi‐DBS led to significant early improvements in HrQoL. Despite sustained motor improvements many of these initial benefits were lost after 3 years. This may reflect either progression of the disease or adaptive changes in the subjective perception of health‐related wellbeing over time. © 2009 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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