Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
Identifieur interne : 002A44 ( Main/Merge ); précédent : 002A43; suivant : 002A45Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
Auteurs : Maria Stamelou [Allemagne] ; Andreas Matusch [Allemagne] ; David Elmenhorst [Allemagne] ; René Hurlemann [Allemagne] ; Karla M. Eggert [Allemagne] ; Karl Zilles [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Günter U. Höglinger [Allemagne] ; Andreas Bauer [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
English descriptors
- KwdEn :
- 5‐HT, 5‐HT2A receptor, Aged, Brain Mapping, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Female, Fluorine Radioisotopes (metabolism), Humans, Ketanserin (analogs & derivatives), Ketanserin (metabolism), Magnetic Resonance Imaging (methods), Male, Middle Aged, Movement Disorders (etiology), Movement Disorders (pathology), Movement Disorders (radionuclide imaging), PET, PSP, Positron-Emission Tomography (methods), Receptor, Serotonin, 5-HT2A (metabolism), Statistics as Topic, Steele‐Richardson‐Olszewski syndrome, Substantia Nigra (metabolism), Substantia Nigra (radionuclide imaging), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (radionuclide imaging), Up-Regulation (physiology), serotonin.
- MESH :
- chemical , analogs & derivatives : Ketanserin.
- chemical , metabolism : Fluorine Radioisotopes, Ketanserin, Receptor, Serotonin, 5-HT2A.
- complications : Supranuclear Palsy, Progressive.
- etiology : Movement Disorders.
- metabolism : Corpus Striatum, Substantia Nigra.
- methods : Magnetic Resonance Imaging, Positron-Emission Tomography.
- pathology : Movement Disorders.
- physiology : Up-Regulation.
- radionuclide imaging : Corpus Striatum, Movement Disorders, Substantia Nigra, Supranuclear Palsy, Progressive.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Statistics as Topic.
Abstract
A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22533
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Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1170">1170</biblScope><biblScope unit="page" to="1175">1175</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C9C7F6F48A73FC841BA75DE92A7EA650E09C4457</idno><idno type="DOI">10.1002/mds.22533</idno><idno type="ArticleID">MDS22533</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5‐HT</term><term>5‐HT2A receptor</term><term>Aged</term><term>Brain Mapping</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Female</term><term>Fluorine Radioisotopes (metabolism)</term><term>Humans</term><term>Ketanserin (analogs & derivatives)</term><term>Ketanserin (metabolism)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (pathology)</term><term>Movement Disorders (radionuclide imaging)</term><term>PET</term><term>PSP</term><term>Positron-Emission Tomography (methods)</term><term>Receptor, Serotonin, 5-HT2A (metabolism)</term><term>Statistics as Topic</term><term>Steele‐Richardson‐Olszewski syndrome</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (radionuclide imaging)</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term><term>Up-Regulation (physiology)</term><term>serotonin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ketanserin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Ketanserin</term><term>Receptor, Serotonin, 5-HT2A</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Movement Disorders</term><term>Substantia Nigra</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics as Topic</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society</div></front></TEI><double doi="10.1002/mds.22533"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name></author><author><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name></author><author><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name></author><author><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C9C7F6F48A73FC841BA75DE92A7EA650E09C4457</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22533</idno><idno type="url">https://api.istex.fr/document/C9C7F6F48A73FC841BA75DE92A7EA650E09C4457/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002E10</idno><idno type="wicri:Area/Istex/Curation">002E10</idno><idno type="wicri:Area/Istex/Checkpoint">000D85</idno><idno type="wicri:doubleKey">0885-3185:2009:Stamelou M:nigrostriatal:upregulation:of</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Düsseldorf, Düsseldorf</wicri:regionArea><wicri:noRegion>Düsseldorf</wicri:noRegion><wicri:noRegion>Düsseldorf</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1170">1170</biblScope><biblScope unit="page" to="1175">1175</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C9C7F6F48A73FC841BA75DE92A7EA650E09C4457</idno><idno type="DOI">10.1002/mds.22533</idno><idno type="ArticleID">MDS22533</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5‐HT</term><term>5‐HT2A receptor</term><term>PET</term><term>PSP</term><term>Steele‐Richardson‐Olszewski syndrome</term><term>serotonin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy.</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Biophysics-Medicine (INB-3), Research Center Jülich, Jülich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics-Medicine (INB-3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name></author><author><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name></author><author><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M" last="Eggert">Karla M. Eggert</name></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U" last="Höglinger">Günter U. Höglinger</name></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22533</idno><idno type="RBID">pubmed:19353726</idno><idno type="pmid">19353726</idno><idno type="wicri:Area/PubMed/Corpus">001D61</idno><idno type="wicri:Area/PubMed/Curation">001D61</idno><idno type="wicri:Area/PubMed/Checkpoint">001C90</idno><idno type="wicri:Area/Ncbi/Merge">002616</idno><idno type="wicri:Area/Ncbi/Curation">002616</idno><idno type="wicri:Area/Ncbi/Checkpoint">002616</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy.</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neuroscience and Biophysics-Medicine (INB-3), Research Center Jülich, Jülich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics-Medicine (INB-3), Research Center Jülich, Jülich</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Juliers</settlement></placeName></affiliation></author><author><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name></author><author><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name></author><author><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M" last="Eggert">Karla M. Eggert</name></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U" last="Höglinger">Günter U. Höglinger</name></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Female</term><term>Fluorine Radioisotopes (metabolism)</term><term>Humans</term><term>Ketanserin (analogs & derivatives)</term><term>Ketanserin (metabolism)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (pathology)</term><term>Movement Disorders (radionuclide imaging)</term><term>Positron-Emission Tomography (methods)</term><term>Receptor, Serotonin, 5-HT2A (metabolism)</term><term>Statistics as Topic</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (radionuclide imaging)</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term><term>Up-Regulation (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Ketanserin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Ketanserin</term><term>Receptor, Serotonin, 5-HT2A</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Movement Disorders</term><term>Substantia Nigra</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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