Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy.
Identifieur interne : 002616 ( Ncbi/Checkpoint ); précédent : 002615; suivant : 002617Nigrostriatal upregulation of 5-HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy.
Auteurs : Maria Stamelou [Allemagne] ; Andreas Matusch ; David Elmenhorst ; René Hurlemann ; Karla M. Eggert ; Karl Zilles ; Wolfgang H. Oertel ; Günter U. Höglinger ; Andreas BauerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Brain Mapping, Corpus Striatum (metabolism), Corpus Striatum (radionuclide imaging), Female, Fluorine Radioisotopes (metabolism), Humans, Ketanserin (analogs & derivatives), Ketanserin (metabolism), Magnetic Resonance Imaging (methods), Male, Middle Aged, Movement Disorders (etiology), Movement Disorders (pathology), Movement Disorders (radionuclide imaging), Positron-Emission Tomography (methods), Receptor, Serotonin, 5-HT2A (metabolism), Statistics as Topic, Substantia Nigra (metabolism), Substantia Nigra (radionuclide imaging), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (radionuclide imaging), Up-Regulation (physiology).
- MESH :
- chemical , analogs & derivatives : Ketanserin.
- chemical , metabolism : Fluorine Radioisotopes, Ketanserin, Receptor, Serotonin, 5-HT2A.
- complications : Supranuclear Palsy, Progressive.
- etiology : Movement Disorders.
- metabolism : Corpus Striatum, Substantia Nigra.
- methods : Magnetic Resonance Imaging, Positron-Emission Tomography.
- pathology : Movement Disorders.
- physiology : Up-Regulation.
- radionuclide imaging : Corpus Striatum, Movement Disorders, Substantia Nigra, Supranuclear Palsy, Progressive.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Statistics as Topic.
Abstract
A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings.
DOI: 10.1002/mds.22533
PubMed: 19353726
Affiliations:
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<front><div type="abstract" xml:lang="en">A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic-rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5-HT(2A)) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up-regulation of 5-HT(2A) receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5- HT(2A) receptor densities showed no changes upon partial-volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP-rating scale) pointing to a functional relevance of the described findings.</div>
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<name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name>
<name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U" last="Höglinger">Günter U. Höglinger</name>
<name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name>
<name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name>
<name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H" last="Oertel">Wolfgang H. Oertel</name>
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<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name>
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