Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
Identifieur interne : 002E10 ( Istex/Curation ); précédent : 002E09; suivant : 002E11Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
Auteurs : Maria Stamelou [Allemagne] ; Andreas Matusch [Allemagne] ; David Elmenhorst [Allemagne] ; René Hurlemann [Allemagne] ; Karla M. Eggert [Allemagne] ; Karl Zilles [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Günter U. Höglinger [Allemagne] ; Andreas Bauer [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
English descriptors
- KwdEn :
Abstract
A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22533
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002E10
Links to Exploration step
ISTEX:C9C7F6F48A73FC841BA75DE92A7EA650E09C4457Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry, University of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Düsseldorf, Düsseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C9C7F6F48A73FC841BA75DE92A7EA650E09C4457</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22533</idno><idno type="url">https://api.istex.fr/document/C9C7F6F48A73FC841BA75DE92A7EA650E09C4457/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002E10</idno><idno type="wicri:Area/Istex/Curation">002E10</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy</title><author><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Matusch, Andreas" sort="Matusch, Andreas" uniqKey="Matusch A" first="Andreas" last="Matusch">Andreas Matusch</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Elmenhorst, David" sort="Elmenhorst, David" uniqKey="Elmenhorst D" first="David" last="Elmenhorst">David Elmenhorst</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation></author><author><name sortKey="Hurlemann, Rene" sort="Hurlemann, Rene" uniqKey="Hurlemann R" first="René" last="Hurlemann">René Hurlemann</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychiatry, University of Bonn, Bonn, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Zilles, Karl" sort="Zilles, Karl" uniqKey="Zilles K" first="Karl" last="Zilles">Karl Zilles</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>C. & O. Vogt Institute for Brain Research, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Hoglinger, Gunter U" sort="Hoglinger, Gunter U" uniqKey="Hoglinger G" first="Günter U." last="Höglinger">Günter U. Höglinger</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Philipps University, Marburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University, Marburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea></affiliation></author><author><name sortKey="Bauer, Andreas" sort="Bauer, Andreas" uniqKey="Bauer A" first="Andreas" last="Bauer">Andreas Bauer</name><affiliation wicri:level="1"><mods:affiliation>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Neuroscience and Biophysics–Medicine (INB‐3), Research Center Jülich, Jülich</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, University of Düsseldorf, Düsseldorf, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Günter U. Höglinger, Department of Neurology, Philipps University, Rudolf‐Bultmann Str. 8, Marburg 35039, GermanyAndreas Bauer, Institute of Neuroscience and Biophysics–Medicine (, Research Center Jülich, Jülich 52425</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-06-15">2009-06-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1170">1170</biblScope><biblScope unit="page" to="1175">1175</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C9C7F6F48A73FC841BA75DE92A7EA650E09C4457</idno><idno type="DOI">10.1002/mds.22533</idno><idno type="ArticleID">MDS22533</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>5‐HT</term><term>5‐HT2A receptor</term><term>PET</term><term>PSP</term><term>Steele‐Richardson‐Olszewski syndrome</term><term>serotonin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A dysfunction of multiple neurotransmitter systems is assumed as a neurochemical basis of the akinetic‐rigid syndrome of progressive supranuclear palsy (PSP). In vitro studies have produced conflicting results on the serotoninergic system in PSP. We, therefore, studied the binding potential of the serotonin 2A (5‐HT2A) receptor ligand [18F]altanserin in 8 patients with clinically probable PSP and 13 healthy controls using positron emission tomography. We found an up‐regulation of 5‐HT2A receptors in the substantia nigra and, to a lower degree, in the striatum, while neocortical 5‐ HT2A receptor densities showed no changes upon partial‐volume correction. Nigral and striatal receptor changes were significantly correlated with patients' scores of motor dysfunction (UPDRS III, PSP‐rating scale) pointing to a functional relevance of the described findings. © 2009 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E10 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002E10 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:C9C7F6F48A73FC841BA75DE92A7EA650E09C4457
|texte= Nigrostriatal upregulation of 5‐HT2A receptors correlates with motor dysfunction in progressive supranuclear palsy
}}
| This area was generated with Dilib version V0.6.23. |  |