MovDisordV3, Main, Merge, bibRecord, 002716

Decision Making in De Novo Parkinson's Disease

Identifieur interne : 002716 ( Main/Merge ); précédent : 002715; suivant : 002717

Decision Making in De Novo Parkinson's Disease

Auteurs : Michele Poletti [Italie] ; Daniela Frosini [Italie] ; Claudio Lucetti [Italie] ; Paolo Del Dotto [Italie] ; Roberto Ceravolo [Italie] ; Ubaldo Bonuccelli [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0377344

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Prise de décision, De novo, Traitement, Amygdale.
Wicri :
- topic : Prise de décision.

English descriptors

KwdEn :
- Amygdala, De novo, Decision making, Nervous system diseases, Parkinson disease, Treatment.

Abstract

The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.

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Pascal:10-0377344

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Decision Making in De Novo Parkinson's Disease

Decision Making in De Novo Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri