Movement Disorders (revue)

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Decision Making in De Novo Parkinson's Disease

Identifieur interne : 002325 ( PascalFrancis/Curation ); précédent : 002324; suivant : 002326

Decision Making in De Novo Parkinson's Disease

Auteurs : Michele Poletti [Italie] ; Daniela Frosini [Italie] ; Claudio Lucetti [Italie] ; Paolo Del Dotto [Italie] ; Roberto Ceravolo [Italie] ; Ubaldo Bonuccelli [Italie]

Source :

RBID : Pascal:10-0377344

Descripteurs français

English descriptors

Abstract

The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.
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A05       @2 25
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A08 01  1  ENG  @1 Decision Making in De Novo Parkinson's Disease
A11 01  1    @1 POLETTI (Michele)
A11 02  1    @1 FROSINI (Daniela)
A11 03  1    @1 LUCETTI (Claudio)
A11 04  1    @1 DEL DOTTO (Paolo)
A11 05  1    @1 CERAVOLO (Roberto)
A11 06  1    @1 BONUCCELLI (Ubaldo)
A14 01      @1 Neurology Unit, USL of Viareggio @3 ITA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 6 aut.
A14 02      @1 Department of Neuroscience, University of Pisa @2 Pisa @3 ITA @Z 2 aut. @Z 5 aut. @Z 6 aut.
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A21       @1 2010
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A44       @0 0000 @1 © 2010 INIST-CNRS. All rights reserved.
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C01 01    ENG  @0 The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.
C02 01  X    @0 002B17
C02 02  X    @0 002B17G
C03 01  X  FRE  @0 Maladie de Parkinson @2 NM @5 01
C03 01  X  ENG  @0 Parkinson disease @2 NM @5 01
C03 01  X  SPA  @0 Parkinson enfermedad @2 NM @5 01
C03 02  X  FRE  @0 Pathologie du système nerveux @5 02
C03 02  X  ENG  @0 Nervous system diseases @5 02
C03 02  X  SPA  @0 Sistema nervioso patología @5 02
C03 03  X  FRE  @0 Prise de décision @5 09
C03 03  X  ENG  @0 Decision making @5 09
C03 03  X  SPA  @0 Toma decision @5 09
C03 04  X  FRE  @0 De novo @5 10
C03 04  X  ENG  @0 De novo @5 10
C03 04  X  SPA  @0 De novo @5 10
C03 05  X  FRE  @0 Traitement @5 11
C03 05  X  ENG  @0 Treatment @5 11
C03 05  X  SPA  @0 Tratamiento @5 11
C03 06  X  FRE  @0 Amygdale @5 12
C03 06  X  ENG  @0 Amygdala @5 12
C03 06  X  SPA  @0 Amígdala @5 12
C07 01  X  FRE  @0 Pathologie de l'encéphale @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Syndrome extrapyramidal @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 242
N44 01      @1 OTO
N82       @1 OTO

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Pascal:10-0377344

Le document en format XML

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<div type="abstract" xml:lang="en">The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.</div>
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<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21>
<s1>242</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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