MovDisordV3, PascalFrancis, Corpus, bibRecord, 000994

Decision Making in De Novo Parkinson's Disease

Identifieur interne : 000994 ( PascalFrancis/Corpus ); précédent : 000993; suivant : 000995

Decision Making in De Novo Parkinson's Disease

Auteurs : Michele Poletti ; Daniela Frosini ; Claudio Lucetti ; Paolo Del Dotto ; Roberto Ceravolo ; Ubaldo Bonuccelli

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0377344

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Prise de décision, De novo, Traitement, Amygdale.

English descriptors

KwdEn :
- Amygdala, De novo, Decision making, Nervous system diseases, Parkinson disease, Treatment.

Abstract

The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A06				`@2 10`
A08	`01`	`1`	`ENG`	`@1 Decision Making in De Novo Parkinson's Disease`
A11	`01`	`1`		`@1 POLETTI (Michele)`
A11	`02`	`1`		`@1 FROSINI (Daniela)`
A11	`03`	`1`		`@1 LUCETTI (Claudio)`
A11	`04`	`1`		`@1 DEL DOTTO (Paolo)`
A11	`05`	`1`		`@1 CERAVOLO (Roberto)`
A11	`06`	`1`		`@1 BONUCCELLI (Ubaldo)`
A14	`01`			`@1 Neurology Unit, USL of Viareggio @3 ITA @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Neuroscience, University of Pisa @2 Pisa @3 ITA @Z 2 aut. @Z 5 aut. @Z 6 aut.`
A20				`@1 1432-1436`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000194762830140`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 40 ref.`
A47	`01`	`1`		`@0 10-0377344`
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C01	`01`		`ENG`	@0 The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.
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C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
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C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
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C03	`03`	`X`	`FRE`	`@0 Prise de décision @5 09`
C03	`03`	`X`	`ENG`	`@0 Decision making @5 09`
C03	`03`	`X`	`SPA`	`@0 Toma decision @5 09`
C03	`04`	`X`	`FRE`	`@0 De novo @5 10`
C03	`04`	`X`	`ENG`	`@0 De novo @5 10`
C03	`04`	`X`	`SPA`	`@0 De novo @5 10`
C03	`05`	`X`	`FRE`	`@0 Traitement @5 11`
C03	`05`	`X`	`ENG`	`@0 Treatment @5 11`
C03	`05`	`X`	`SPA`	`@0 Tratamiento @5 11`
C03	`06`	`X`	`FRE`	`@0 Amygdale @5 12`
C03	`06`	`X`	`ENG`	`@0 Amygdala @5 12`
C03	`06`	`X`	`SPA`	`@0 Amígdala @5 12`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
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Format Inist (serveur)

NO :	PASCAL 10-0377344 INIST
ET :	Decision Making in De Novo Parkinson's Disease
AU :	POLETTI (Michele); FROSINI (Daniela); LUCETTI (Claudio); DEL DOTTO (Paolo); CERAVOLO (Roberto); BONUCCELLI (Ubaldo)
AF :	Neurology Unit, USL of Viareggio/Italie (1 aut., 3 aut., 4 aut., 6 aut.); Department of Neuroscience, University of Pisa/Pisa/Italie (2 aut., 5 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 10; Pp. 1432-1436; Bibl. 40 ref.
LA :	Anglais
EA :	The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Prise de décision; De novo; Traitement; Amygdale
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Decision making; De novo; Treatment; Amygdala
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Toma decision; De novo; Tratamiento; Amígdala
LO :	INIST-20953.354000194762830140
ID :	10-0377344

Links to Exploration step

Pascal:10-0377344

Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.</div>
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<server><NO>PASCAL 10-0377344 INIST</NO>
<ET>Decision Making in De Novo Parkinson's Disease</ET>
<AU>POLETTI (Michele); FROSINI (Daniela); LUCETTI (Claudio); DEL DOTTO (Paolo); CERAVOLO (Roberto); BONUCCELLI (Ubaldo)</AU>
<AF>Neurology Unit, USL of Viareggio/Italie (1 aut., 3 aut., 4 aut., 6 aut.); Department of Neuroscience, University of Pisa/Pisa/Italie (2 aut., 5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 10; Pp. 1432-1436; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>The aim is to study decision making in patients with de novo Parkinson's disease (PD). Recent studies reported that medicated patients with PD have poor performances compared with age-matched healthy controls in decision making tasks, specially in the Iowa Gambling Task. Two principal causal hypotheses have been proposed to explain this phenomenon: the overdosing effects of dopaminergic therapy on the orbital frontostriatal circuit that is involved in reward processing, or an amygdala dysfunction, as suggested by similar Skin Conductance Responses of patients with PD and amygdala-damaged patients while performing this task. The assessment of decision making with the Iowa Gambling Task was conducted in 30 nondemented and nondepressed patients with de novo PD and in 25 age-matched healthy controls. No statistically significant difference emerged between performances of de novo PD patients and performances of healthy controls. De novo PD patients have performances in the Iowa Gambling Task similar to those of age-matched healthy controls, suggesting that difficulties in decision making emerge, at least in de novo PD patients, by dopaminergic overstimulation of the orbital frontostriatal circuits.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Prise de décision; De novo; Traitement; Amygdale</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Decision making; De novo; Treatment; Amygdala</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Toma decision; De novo; Tratamiento; Amígdala</SD>
<LO>INIST-20953.354000194762830140</LO>
<ID>10-0377344</ID>
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Movement Disorders (revue)

Decision Making in De Novo Parkinson's Disease

Decision Making in De Novo Parkinson's Disease

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