Movement Disorders (revue)

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Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study

Identifieur interne : 002342 ( Main/Merge ); précédent : 002341; suivant : 002343

Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study

Auteurs : Alessandra Nicoletti [Italie] ; Pierfrancesco Pugliese [Italie] ; Giuseppe Nicoletti [Italie] ; Gennarina Arabia [Italie] ; Grazia Annesi [Italie] ; Michele De Mari [Italie] ; Paolo Lamberti [Italie] ; Lucia Grasso [Italie] ; Roberto Marconi [Italie] ; Antonio Epifanio [Italie] ; Letterio Morgante [Italie] ; Autilia Cozzolino [Italie] ; Paolo Barone [Italie] ; Giusi Torchia [Italie] ; Aldo Quattrone [Italie] ; Mario Zappia [Italie]

Source :

RBID : Pascal:10-0491588

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English descriptors

Abstract

We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.

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Pascal:10-0491588

Le document en format XML

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<title xml:lang="en" level="a">Voluptuary Habits and Clinical Subtypes of Parkinson's Disease: The FRAGAMP Case-Control Study</title>
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<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</s1>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto di Scienze Neurologiche, Centro Nazionale delle Ricerche, Piano Lago di Mangone Cosenza</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<inist:fA14 i1="03">
<s1>Clinical Neurologica, Universitd "Magna Græcia" di Catanzaro</s1>
<s2>Catanzaro</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catanzaro</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Dipartimento di Neuroscienze, Università di Catania</s1>
<s2>Catania</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Catania</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint>
<date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Alcohol</term>
<term>Case control study</term>
<term>Epidemiology</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Subtype</term>
<term>Tobacco smoking</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Maladie de Parkinson</term>
<term>Tabagisme</term>
<term>Pathologie du système nerveux</term>
<term>Soustype</term>
<term>Etude cas témoin</term>
<term>Epidémiologie</term>
<term>Alcool</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Tabagisme</term>
<term>Alcool</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">We evaluated the possible association between smoking, coffee drinking, and alcohol consumption and Parkinson's disease (PD). The FRAGAMP study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Adjusted ORs were estimated using unconditional logistic regression. Smoking, coffee, and alcohol consumption were also considered as surrogate markers of lifestyle and analysis was carried out considering the presence of at least one, two, or three factors. This latter analysis was separately performed considering Tremor-Dominant (TD) and Akinetic-Rigid (AR) patients. Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. Multivariate analysis showed a significant negative association between PD and cigarette smoking (OR 0.51; 95%CI 0.36-0.72), coffee drinking (OR 0.61; 95%CI 0.43-0.87) and wine consumption (OR 0.62; 95%CI 0.44-0.86); a significant trend dose-effect (P < 0.05) has been found for all the factors studied. We have also found a trend dose-effect for the presence of at least one, two or three factors with a greater risk reduction (83%) for the presence of three factors. However, a different strength of association between TD and AR was found with a greater risk reduction for the AR patients. We found a significant inverse association between PD smoking, coffee, and alcohol consumption. When analysis was carried out considering the association of these factors as possible surrogate markers of a peculiar lifestyle the association was stronger for the AR phenotype.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Italie</li>
</country>
</list>
<tree>
<country name="Italie">
<noRegion>
<name sortKey="Nicoletti, Alessandra" sort="Nicoletti, Alessandra" uniqKey="Nicoletti A" first="Alessandra" last="Nicoletti">Alessandra Nicoletti</name>
</noRegion>
<name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
<name sortKey="Arabia, Gennarina" sort="Arabia, Gennarina" uniqKey="Arabia G" first="Gennarina" last="Arabia">Gennarina Arabia</name>
<name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
<name sortKey="Cozzolino, Autilia" sort="Cozzolino, Autilia" uniqKey="Cozzolino A" first="Autilia" last="Cozzolino">Autilia Cozzolino</name>
<name sortKey="De Mari, Michele" sort="De Mari, Michele" uniqKey="De Mari M" first="Michele" last="De Mari">Michele De Mari</name>
<name sortKey="Epifanio, Antonio" sort="Epifanio, Antonio" uniqKey="Epifanio A" first="Antonio" last="Epifanio">Antonio Epifanio</name>
<name sortKey="Grasso, Lucia" sort="Grasso, Lucia" uniqKey="Grasso L" first="Lucia" last="Grasso">Lucia Grasso</name>
<name sortKey="Lamberti, Paolo" sort="Lamberti, Paolo" uniqKey="Lamberti P" first="Paolo" last="Lamberti">Paolo Lamberti</name>
<name sortKey="Marconi, Roberto" sort="Marconi, Roberto" uniqKey="Marconi R" first="Roberto" last="Marconi">Roberto Marconi</name>
<name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name>
<name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name>
<name sortKey="Pugliese, Pierfrancesco" sort="Pugliese, Pierfrancesco" uniqKey="Pugliese P" first="Pierfrancesco" last="Pugliese">Pierfrancesco Pugliese</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Torchia, Giusi" sort="Torchia, Giusi" uniqKey="Torchia G" first="Giusi" last="Torchia">Giusi Torchia</name>
<name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name>
</country>
</tree>
</affiliations>
</record>

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